Best Clinical Practice Guidance for clinicians dealing with children presenting with Molar-Incisor-Hypomineralisation (MIH)

Lygidakis, N. A.; Wong, F.S.L.; Jälevik, Birgitta; Vierrou, A M; Alaluusua, Satu; Espelid, Ivar

doi:10.1007/bf03262716

Cited by 401 publications

(575 citation statements)

References 18 publications

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“…4,5 Since the early mineralization phase of the FPMs occurs close to birth until the first year of life, the teeth are susceptible to the various etiological factors causing MIH during this critical stage of tooth development. 8 Lygidakis et al 5 found that MIH was more common in a study group with perinatal complications of Caesarean section, premature birth, prolonged delivery and twinning. This case report presented monozygotic twins that were born on term, via Caesarean section delivery with a normal birth weight.…”

Section: Discussionmentioning

confidence: 97%

“…8,14 Weerheijm et al 15 also proposed that the clinical appearance of the 4 FPMs and 8 incisors should be recorded for the following features which will aid in the correct diagnosis of the condition: presence or absence of demarcated opacities; post eruptive enamel breakdown; atypical restorations; extraction of a FPM; failure of eruption of a FPM or an incisor. Teeth affected by MIH, with or without enamel loss, are often associated with hypersensitivity to air and cold stimuli.…”

Section: Case Reportsmentioning

confidence: 99%

“…7 The FPMs may not be affected to the same degree in an individual and some molars could be relatively unaffected. 8 Hypomineralized teeth were initially classified into three groups, based on the severity of the enamel defect: mild (white, yellow or brown discoloration of the enamel), moderate (enamel loss only) and severe (loss of enamel in combination with affected dentin). 9 Due to some similarities in the clinical appearance of the moderate and severe cases, Lygidakis et al 8 suggested the use of only two categories: mild and moderate-severe.…”

Section: Introductionmentioning

confidence: 99%

“…8 Hypomineralized teeth were initially classified into three groups, based on the severity of the enamel defect: mild (white, yellow or brown discoloration of the enamel), moderate (enamel loss only) and severe (loss of enamel in combination with affected dentin). 9 Due to some similarities in the clinical appearance of the moderate and severe cases, Lygidakis et al 8 suggested the use of only two categories: mild and moderate-severe. The mild cases include demarcated enamel opacities with intact surfaces, occasional sensitivity and mild esthetic concerns.…”

Section: Introductionmentioning

confidence: 99%

“…In moderate-severe cases, there is enamel surface breakdown, persistent or spontaneous hypersensitivity with major esthetic concerns. 8 The aim of this case report is to discuss the features and management of MIH in a set of healthy monozygotic twin males.…”

Section: Introductionmentioning

confidence: 99%

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Molar Incisor Hypomineralization in Monozygotic Twins: A Case Report

Velissariou¹,

Chandwani²

2017

EDUJ

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Aim: The aim of this case report is to discuss the features of molar incisor hypomineralization (MIH), a developmental enamel defect, which was noted in a set of monozygotic twin males. Summary: MIH is the hypomineralization of one to four first permanent molars (FPMs) frequently associated with affected incisors and varies in clinical severity. Early diagnosis and management of the condition is paramount and will avoid the premature loss of the molars. Key learning points: The clinical characteristics, as well as the short and long term management of this condition are discussed.

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Section: Discussionmentioning

confidence: 97%

Section: Case Reportsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Molar Incisor Hypomineralization in Monozygotic Twins: A Case Report

Velissariou¹,

Chandwani²

2017

EDUJ

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Association of High-Dose Vitamin D Supplementation During Pregnancy With the Risk of Enamel Defects in Offspring

et al. 2019

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IMPORTANCE Enamel defects of developmental origin affect up to 38% of schoolchildren and is recognized as a global public health challenge. The impaired enamel formation results in pain owing to hypersensitivity, posteruptive breakdowns, rapid caries progression, and extractions in some cases. The etiology is unknown; therefore, prevention is currently not possible.OBJECTIVE To assess the association of a high-dose vitamin D supplementation in pregnant women with enamel defects and caries in their offspring. DESIGN, SETTING, AND PARTICIPANTS Post hoc analysis of a double-blind, single-center, randomized clinical trial, the Copenhagen Prospective Studies on Asthma in Childhood 2010 cohort (COPSAC 2010 ). Enrollment began March 2009 and included 623 women recruited at 24 weeks of pregnancy and 588 of their children. A dental examination was completed at age 6 years in 496 of 588 children (84%). Data were analyzed in 2018. INTERVENTION High-dose vitamin D 3 (2400 IU/d; N = 315) or matching placebo tablets (N = 308) from pregnancy week 24 to 1 week post partum. In addition, all women received 400 IU/d of vitamin D 3 as part of standard care.MAIN OUTCOMES AND MEASURES Enamel defect was defined as having at least 1 molar affected by demarcated opacity, enamel breakdown, and/or atypical restoration. Caries was defined as decayed, missing, or filled surfaces in both the deciduous and permanent dentitions (World Health Organization standard). RESULTSThe risk of enamel defects in the permanent dentition was lower in the offspring of mothers who received high-dose vitamin D supplementation during pregnancy compared with standard dose (15.1% [n = 26 of 172] vs 27.5% [n = 44 of 160]; odds ratio, 0.47; 95% CI, 0.27-0.81). A similar association was observed for the deciduous dentition (8.6% [n = 21 of 244] vs 15.9% [n = 40 of 252]; odds ratio, 0.50; 95% CI, 0.28-0.87). There was no association between supplementation and caries.CONCLUSIONS AND RELEVANCE High-dose vitamin D supplementation during pregnancy was associated with approximately 50% reduced odds of enamel defects in the offspring. This suggests prenatal vitamin D supplementation as a preventive intervention for enamel defects, with a clinically important association with dental health.TRIAL REGISTRATION ClinicalTrials.gov identifier: NCT00856947

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