Best Clinical Practices with ATX-101 for Submental Fat Reduction: Patient-related Factors and Physician Considerations

Teller, Craig; Chiu, Annie; Chesnut, Cameron; Sherman, D H; Montes, José Raúl; Gaspard, Sara; Keaney, Terrence; Sadick, Neil S.; Yoelin, Steve; Sangha, Sara; Shridharani, Sachin M.

doi:10.1097/gox.0000000000003668

Cited by 9 publications

(6 citation statements)

References 22 publications

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“…Over 90% of patients treated with ATX-101 in open-label clinical trials or the REFINE trial showed either improvement or no change in the submental fullness. However, patients with excess sub-platysmal fat or severe submental skin laxity may be better treated by alternative treatment options to address submental fullness or skin-tightening therapy along with ATX-101 administration [22,23]. Teller et al [23] reported in their study that for the reduction of SMF, the finest clinical practices regarding the use of ATX-101 should enable physicians to boost treatment outcomes and patient experience.…”

Section: Discussionmentioning

confidence: 99%

An Assessment of the Reduction of Submental Fullness With ATX-101 (Deoxycholic Acid Injection) in the Expanded Safe Zone

Khan¹,

Ain²,

Bhatti³

et al. 2023

Cureus

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Background and objectiveFacial aesthetics have a huge impact on how individuals view themselves and are viewed by society. The aesthetics of the face are tremendously influenced by the shape of the chin and neck. In this study, we aimed to observe the outcomes in individuals after the use of ATX-101 (deoxycholic acid injection) in an expanded safe zone for submental fullness. To ensure optimal outcomes and reduce the risk of adverse events, appropriate patient selection is the key. ATX-101 treatment may be administered in combination with hyaluronic acid fillers, botulinum toxins, cryolipolysis, and radiofrequency treatment. This is the first study of its kind to be carried out at the national level in Pakistan. Materials and methodsThis was a quasi-experimental study conducted at the Rawalian Burn and Reconstructive Surgery Unit, Holy Family Hospital, Rawalpindi, Pakistan for a period of nine months, from 10-1-2021 to 11-10-2021. A total of 62 patients who fulfilled the inclusion criteria were enrolled. We recorded if any complications had occurred or not. Moreover, the total number of treatment sessions, the volume of injectables used, and the interval between sessions were also documented. ATX-101 package was injected into the treatment area. Due care was taken to avoid the region of the marginal mandibular nerve. After the procedure, outcomes and complications were observed. ResultsIn this study, patient satisfaction was reported in 59 (95.2%) patients. After the fourth session, final improvement was observed in 59 (95.16%) patients. Tenderness was found in seven (11.3%) patients, bruising was noted in four (6.5%), edema was found in seven (11.3%), numbness was noted in one (1.6%), whereas paresis and alopecia were not found in any of the patients. ConclusionOur study concluded that ATX-101 is a very useful modality with fewer complication rates and is associated with significant improvement in the expanded safe zone for submental fullness.

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Section: Discussionmentioning

confidence: 99%

An Assessment of the Reduction of Submental Fullness With ATX-101 (Deoxycholic Acid Injection) in the Expanded Safe Zone

Khan¹,

Ain²,

Bhatti³

et al. 2023

Cureus

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“…However, they may necessitate multiple sessions, and the results can take time to become noticeable. On the other hand, non-surgical energy-based methods, such as radiofrequency devices and cryolipolysis, can provide more rapid results with a single session but may entail discomfort during treatment and potentially longer recovery times due to swelling and bruising [1][2][3][4][5][6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…The increasing concern regarding these issues has driven interest in non-invasive and minimally invasive treatments for submental fat and tissue laxity. Patients now have various treatment options, including injectable treatments, nonsurgical energy-based methods, and surgical procedures [1][2][3][4][5][6][7][8][9][10]. One minimally invasive option is laser lipolysis.…”

Section: Introductionmentioning

confidence: 99%

New Protocol: EndoliftX Laser and Hyaluronic Ac+ Calcium Hydroxiapaptite as an Effective Approach for Facial Rejuvenation- Case Series of 7 Patients

2023

Dearma J Cosmetic Laser Therapy

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Background: Excessive submental fat and tissue laxity can significantly impact an individual's aesthetic appearance, leading to cosmetic dissatisfaction and concerns about aging. Non-invasive and minimally invasive treatments have gained popularity as alternatives to surgical interventions. Laser lipolysis, such as EndoliftX®, has emerged as a promising approach for submental fat reduction, and hybrid fillers, like HArmonyCa, have shown potential for enhancing tissue laxity. Objective: This study aimed to evaluate the efficacy and long-term outcomes of a novel combined treatment protocol utilizing laser lipolysis and hybrid filler injection for submental fat reduction and tissue tightening. Methods and Materials: A single-center, prospective, quasi-experimental controlled study was conducted, enrolling seven patients aged between 49 and 67 years. The protocol EndoliftX®, involved a 1470nm diode laser (LASEmaR 1500® Eufoton® Trieste,Italy) treatment (Endolift) followed by hybrid filler (HArmonyCa) injection. Various assessments, including clinical examination, Glogau Scale scoring, and 3D imaging, were performed at baseline and follow-up visits. Results: The results demonstrated significant reductions in submental fat, improved cutaneous elasticity, and reduced wrinkle severity according to the Glogau Scale. Notably, these improvements were visible almost immediately post-procedure and continued to enhance over time, remaining prominent even after 12 months of observation. The treatment was associated with minimal discomfort and downtime. Conclusion: The study highlights the effectiveness and longevity of the combined treatment protocol, making it a valuable option for individuals seeking non-surgical solutions for submental fat reduction and tissue tightening. While further research with control groups is warranted, laser lipolysis with EndoliftX®, and hybrid filler injection with HArmonyCa offer a minimally invasive and well-tolerated approach to address submental concerns and achieve favorable aesthetic outcomes, particularly in patients looking to avoid more invasive techniques.

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“…The cost of a laser source, which primarily makes up laser lipolysis devices, 12 can be upward of $1500. 13 In addition, deoxycholic acid, 14 as a nonregulated commercial product, can cost almost $500 for 100 mg of product. 15 To overcome such limitations, we have investigated a potential new, low-cost, nonsurgical fat reduction modality involving the use of in situ water hydrolysis to modify the biochemical and physical tissue properties.…”

mentioning

confidence: 99%

“Electrochemical Lipolysis Induces Adipocyte Death and Fat Necrosis: In Vivo Pilot Study in Pigs”

Pham

Heidari

Hong

et al. 2023

Plastic &Amp; Reconstructive Surgery

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Fat contouring has trended from invasive surgery to nonsurgical modalities, with 140,314 nonsurgical fat reduction procedures performed in 2020. [1][2][3] Existing minimally invasive treatments can entail high-cost equipment. Current radiofrequency, 4,5 high-intensity focused ultrasound, 6,7 cryolipolysis, 8,9 and laser lipolysis 10,11 medical devices range in cost from one to several tens of thousands of U.S. dollars. The cost of a laser source, which primarily makes up laser lipolysis devices, 12 can be upward of $1500. 13 In addition, deoxycholic acid, 14 as a nonregulated commercial product, can cost almost $500 for 100 mg of product. 15 To overcome such limitations, we have investigated a potential Background: Current minimally invasive fat reduction modalities use equipment that can cost thousands of U.S. dollars. Electrochemical lipolysis (ECLL), using low-cost battery and electrodes (approximately $10), creates acid/base within fat (width, approximately 3 mm), damaging adipocytes. Longitudinal effects of ECLL have not been studied. In this pilot study, the authors hypothesize that in vivo ECLL induces fat necrosis, decreases adipocyte number/viability, and forms lipid droplets. Methods: Two female Yorkshire pigs (50 to 60 kg) received ECLL. In pig 1, 10 sites received ECLL, and 10 sites were untreated. In pig 2, 12 sites received ECLL and 12 sites were untreated. For ECLL, two electrodes were inserted into dorsal subcutaneous fat and direct current was applied for 5 minutes. Adverse effects of excessive pain, bleeding, infection, and agitation were monitored. Histology, live-dead (calcein, Hoechst, ethidium homodimer-1), and morphology (Bodipy and Hoechst) assays were performed on day 0 and postprocedure days 1, 2, 7, 14 (pig 1 and pig 2), and 28 (pig 2). Average particle area, fluorescence signal areas, and adipocytes and lipid droplet numbers were compared. Results: No adverse effects occurred. Live-dead assays showed adipocyte death on the anode on days 0 to 7 and the cathode on days 1 to 2 (not significant). Bodipy showed significant adipocyte loss at all sites (P < 0.001) and lipid droplet formation at the cathode site on day 2 (P = 0.0046). Histology revealed fat necrosis with significant increases in average particle area at the anode and cathode sites by day 14 (+277.3% change compared with untreated, P < 0.0001; +143.4%, P < 0.0001) and day 28 (+498.6%, P < 0.0001; +354.5%, P < 0.0001). Conclusions: In vivo ECLL induces fat necrosis in pigs. Further studies are needed to evaluate volumetric fat reduction. (Plast. Reconstr. Surg. 153: 334e, 2024.) Clinical Relevance Statement: In vivo ECLL induces adipocyte death and fat necrosis. ECLL has the potential to be utilized in body fat contouring.

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Best Clinical Practices with ATX-101 for Submental Fat Reduction: Patient-related Factors and Physician Considerations

Cited by 9 publications

References 22 publications

An Assessment of the Reduction of Submental Fullness With ATX-101 (Deoxycholic Acid Injection) in the Expanded Safe Zone

An Assessment of the Reduction of Submental Fullness With ATX-101 (Deoxycholic Acid Injection) in the Expanded Safe Zone

New Protocol: EndoliftX Laser and Hyaluronic Ac+ Calcium Hydroxiapaptite as an Effective Approach for Facial Rejuvenation- Case Series of 7 Patients

“Electrochemical Lipolysis Induces Adipocyte Death and Fat Necrosis: In Vivo Pilot Study in Pigs”

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