Chronic pain affects up to 30% of the adult population [1] and 11% to 38% of the childhood and adolescent population [2,3]. Its tremendous personal and socioeconomic impact is reflected by its cause of the highest number of years lived with disability [4] and being the most expensive cause of work-related disability in adults [5,6]. In children and adolescents, chronic pain causes decreased participation in recreational activities, difficulty maintaining social contacts, school absence and academic impairment, decreased health related quality of life, and increased health care utilization [3,7].The area of rehabilitation research for patients having persistent pain is on the move with a substantial increase in the scientific understanding of persistent pain over the past decades. This rapid growth in pain science has inspired rehabilitation clinicians and researchers around the globe, leading to breakthrough research and the implementation of contemporary pain science in rehabilitation settings. Still, our understanding of persistent pain continues to grow, not in the least because of fascinating discoveries from areas such as psychoneuroimmunology, epigenetics, exercise physiology, clinical psychology, and nutritional (neuro)biology. This offers unique opportunities to further improve rehabilitation for patients with chronic pain. As age is a determining factor in the uniqueness of the bio-, psycho-, and social factors of persistent pain, this also implies that rehabilitation interventions should be tailored across the lifespan. Also, the diversity of health care disciplines involved in the rehabilitation of chronic pain (e.g., physicians, psychologists, physiotherapists, occupational therapists, nurses, coaches) provides a framework for upgrading rehabilitation for chronic pain towards comprehensive lifestyle approaches.A number of articles published in this Special Issue draw specific attention to interdisciplinary multimodal rehabilitation programs for chronic pain. Ringqvist et al. [8] provide evidence that such programs delivered to adults in specialist care show moderate long-term effect sizes for pain, pain interference in daily life, and perceived health. Interestingly, Pfeifer et al. [9] provide preliminary support for the utility of incorporating an attachment-informed approach within these existing multimodal pain therapies, thereby aiming at advancing the working alliance between patient and therapist. In the realm of pediatric chronic pain rehabilitation, Harrison et al. [10] state that preliminary evidence on interdisciplinary outpatient treatments is promising with regard to improvements in pain