Best of the year: Advanced breast cancer in 2023

Schlam, Ilana; Chavez-MacGregor, Mariana

doi:10.1016/j.breast.2024.103677

Cited by 5 publications

References 27 publications

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Biomimetic Nanosystem Loading Aggregation‐Induced Emission Luminogens and SO₂ Prodrug for Inhibiting Insufficient Photothermal Therapy‐Induced Breast Cancer Recurrence and Metastasis

Zhang,

Ping,

Suo

et al. 2024

Advanced Science

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Photothermal therapy (PTT) holds considerable clinical promise. However, insufficient PTT‐induced tumor recurrence and metastasis is an urgent practical problem that needs to be solved. Herein, a biomimetic mesoporous organosilicon nano‐system called PSAB is designed to precisely deplete cancer stem cells (CSCs) and prevent tumor recurrence and metastasis after PTT. The PSAB system is made up of Aggregation‐induced emission (AIE)‐active photothermal agent, 2TT‐oC26B, and SO2 prodrug, benzothiazole sulfinate (BTS), within mesoporous organosilicon nanoparticles (MON) enclosed by an exterior platelet membrane. PSAB effectively targets CSCs both in vitro and in vivo by P‐selectin/CD44 interaction. The degradation of MON and subsequent release of BTS and AIE molecules are facilitated by intracellular glutathione (GSH). Subsequently, the acidic tumor environment triggers the SO2 gas therapy from BTS. This process leads to the depletion of GSH and CSCs elimination. After combining PSAB with photothermal therapy, there is no significant tumor recurrence or metastasis. These results indicate that SO2 gas therapy and AIE‐mediated PTT act synergistically to offer a unique approach for preventing tumor recurrence and metastasis after PTT, thus holding significant promise for clinical applications in cancer PTT.

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Biomimetic Nanosystem Loading Aggregation‐Induced Emission Luminogens and SO₂ Prodrug for Inhibiting Insufficient Photothermal Therapy‐Induced Breast Cancer Recurrence and Metastasis

Zhang,

Ping,

Suo

et al. 2024

Advanced Science

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Tumor Heterogeneity in Triple-Negative Breast Cancer: Shedding Light on the Role of AKT and RUNX

Vila,

Fernández,

Cascardo

et al. 2024

Interdisciplinary Cancer Research

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Efficacy and safety of antibody-drug conjugates in pretreated HER2-low metastatic breast cancer: A systematic review and network meta-analysis

Schettini,

Nucera,

Pascual

et al. 2025

Cancer Treatment Reviews

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Best of the year: Advanced breast cancer in 2023

Cited by 5 publications

References 27 publications

Biomimetic Nanosystem Loading Aggregation‐Induced Emission Luminogens and SO₂ Prodrug for Inhibiting Insufficient Photothermal Therapy‐Induced Breast Cancer Recurrence and Metastasis

Biomimetic Nanosystem Loading Aggregation‐Induced Emission Luminogens and SO₂ Prodrug for Inhibiting Insufficient Photothermal Therapy‐Induced Breast Cancer Recurrence and Metastasis

Tumor Heterogeneity in Triple-Negative Breast Cancer: Shedding Light on the Role of AKT and RUNX

Efficacy and safety of antibody-drug conjugates in pretreated HER2-low metastatic breast cancer: A systematic review and network meta-analysis

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Best of the year: Advanced breast cancer in 2023

Cited by 5 publications

References 27 publications

Biomimetic Nanosystem Loading Aggregation‐Induced Emission Luminogens and SO2 Prodrug for Inhibiting Insufficient Photothermal Therapy‐Induced Breast Cancer Recurrence and Metastasis

Biomimetic Nanosystem Loading Aggregation‐Induced Emission Luminogens and SO2 Prodrug for Inhibiting Insufficient Photothermal Therapy‐Induced Breast Cancer Recurrence and Metastasis

Tumor Heterogeneity in Triple-Negative Breast Cancer: Shedding Light on the Role of AKT and RUNX

Efficacy and safety of antibody-drug conjugates in pretreated HER2-low metastatic breast cancer: A systematic review and network meta-analysis

Contact Info

Product

Resources

About

Biomimetic Nanosystem Loading Aggregation‐Induced Emission Luminogens and SO₂ Prodrug for Inhibiting Insufficient Photothermal Therapy‐Induced Breast Cancer Recurrence and Metastasis

Biomimetic Nanosystem Loading Aggregation‐Induced Emission Luminogens and SO₂ Prodrug for Inhibiting Insufficient Photothermal Therapy‐Induced Breast Cancer Recurrence and Metastasis