Best practices from nano-risk analysis relevant for other emerging technologies

Abstract

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Metal nanoparticles as a promising technology in targeted cancer treatment

“…Toxic effects are possible despite the particular advantages of nanomaterials due to their tiny size and high surface area which have been shown to boost reactivity with biological targets. Consumer and industrial products based on nanotechnology are nevertheless plagued by a slew of safety and sustainability issues (Grieger, 2019 ). Numerous problems regarding the safety and long-term sustainability of consumer and industrial goods based on nanotechnology remain unresolved (Najahi-Missaoui et al., 2021 ).…”

Placing nanoplastics in the context of global plastic pollution

“…In this regard, the lessons learned from engineered nanomaterials may be drawn upon as we now develop workflows to assess nanoplastics. 97,98 To facilitate the safe and sustainable use of nanomaterials, a suite of frameworks and tools to assess their risks were developed in the last years. [99][100][101] Whereas many of these tools are only able to provide screening-level assessments, there are ongoing activities to develop quantitative, higher-tier tools that can also incorporate uncertainty during the evaluation process.…”

“…[99][100][101] Whereas many of these tools are only able to provide screening-level assessments, there are ongoing activities to develop quantitative, higher-tier tools that can also incorporate uncertainty during the evaluation process. Several learnings, warnings and potential working hypothesis from the field of engineered nanomaterial environmental health and safety, 40,97 as well as recommendations for minimal information reporting in the bio-nano experimental field, 102 are published and will hopefully steer and accelerate nanoplastics research and provide profound understanding on the concentration, fate and environmental health and safety of nanoplastics soon.…”

Features, applications, and sustainability of lipid nanoparticles in cosmeceuticals

“…Significant advances have been made in this field, for example by producing and using safe nano-ingredients such as nano-cellulose derivatives instead of synthetic nano-polymers or implementing green synthesis processes that involve the use of less hazardous and renewable reagents, solvents, and starting materials ( Dahl et al, 2007 , Lu and Ozcan, 2015 , Oehlke et al, 2017 ). Even though significant advancements in the nanotechnology field in the last decade to understand the environmental and toxicological behavior of nanomaterials, opening various concerns regarding the safety and sustainability applications, especially those products designed for internal administration such as nano pharmaceutical products ( Jantunen et al, 2018 , Friedersdorf et al, 2019 , Grieger et al, 2019 ). Recently, regulatory bodies have raised some concerns about assessing the risk and the governance of the type of nanomaterials that can be responded to external stimuli, which are also known as ‘smart nanomaterials’ ( council, 2007 ).…”