Aims: The purpose of the research is to form a philosophical and ideological understanding of the small and medium-sized businesses personnel management effectiveness at the local-national (Slovak case) and global (the case of the European Union and the global economic dimension) levels of economic development. The article focuses on the interpretation peculiarities of the management system functioning in different socio-cultural conditions. Slovakia has both its own national and mental human-dimensional identifications of small and medium-sized business systems and is integrating into the pan-European paradigm of human resource management in the economy. The article offers a philosophical and economic justification for the ways of building progressive systems of economic activity involving employees of small and medium-sized businesses, which will be realised faster under conditions of orderly management strategies. Methodology: The research methodology included general scientific methods, special methodological approaches of scientific and economic discourse, and philosophical methodological principles that play the role of a correlation factor in building a holistic and multi-vector paradigm of personnel management. Results: The results of the study are based on the example of Slovakia and indicate that in the modern economic system of one of the countries of the European Union, two models of management strategies are being coordinated: the nationally oriented and the pan-European. Despite all attempts to unify the system of human resource management in the EU, the socio-economic, cultural, and mental specificity of a region, country or community retains a number of authentic and identifying elements of this cluster of economic activity. Scientific Novelty: The scientific novelty of the study lies in the attempt to build a new philosophy of human resource management in the deeply integrated EU economic system, which is not a traditional attempt to unify the management system in all economic entities of the region but proposes the development of a dynamic paradigm of human potential management. The small and medium-sized businesses, due to the lack of scale of their structures, have more opportunities to implement a dynamic model of human resource management, where the most appropriate economic management characteristics will be actualized in a particular environment. Conclusion: The philosophy of human resource management of small and medium-sized businesses is focused on the following dimensions: axiological, creative and epistemological, ethical, socio-philosophical, anthropological.