Best strategies to recruit and enroll elderly Blacks into clinical and biomedical research

Graham, Lennox; Ngwa, Julius S.; Ntekim, Oyonumo; Ogunlana, Oludolapo; Wolday, Saba; Johnson, Steven T.; Johnson, Megan; Castor, Chimene; Fungwe, Thomas V.; Obisesan, Thomas O.

doi:10.2147/cia.s130112

Cited by 28 publications

(49 citation statements)

References 32 publications

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“…A growing literature provides strategies for recruiting diverse populations into clinical trials. For example, studies have shown the importance of building relationships and trust [30], including family referrals and community stakeholders [31], person-to-person outreach, presentations in the community, and face-to-face meetings [32]. More recently, studies have evaluated the use of popular social media platforms (e.g., Twitter, Facebook [18,33]) in recruiting vulnerable populations.…”

Section: Focus On Reach From the Very Beginningmentioning

confidence: 99%

Reframing implementation science to address inequities in healthcare delivery

Baumann

Cabassa

2020

BMC Health Serv Res

282

273

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Background: Research has generated valuable knowledge in identifying, understanding, and intervening to address inequities in the delivery of healthcare, yet these inequities persist. The best available interventions, programs and policies designed to address inequities in healthcare are not being adopted in routine practice settings. Implementation science can help address this gap by studying the factors, processes, and strategies at multiple levels of a system of care that influence the uptake, use, and the sustainability of these programs for vulnerable populations. We propose that an equity lens can help integrate the fields of implementation science and research that focuses on inequities in healthcare delivery. Main text: Using Proctor et al.' (12) framework as a case study, we reframed five elements of implementation science to study inequities in healthcare. These elements include: 1) focus on reach from the very beginning; 2) design and select interventions for vulnerable populations and low-resource communities with implementation in mind; 3) implement what works and develop implementation strategies that can help reduce inequities in care; 4) develop the science of adaptations; and 5) use an equity lens for implementation outcomes. Conclusions: The goal of this paper is to continue the dialogue on how to critically infuse an equity approach in implementation studies to proactively address healthcare inequities in historically underserved populations. Our examples provide ways to operationalize how we can blend implementation science and healthcare inequities research.

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Section: Focus On Reach From the Very Beginningmentioning

confidence: 99%

Reframing implementation science to address inequities in healthcare delivery

Baumann

Cabassa

2020

BMC Health Serv Res

282

273

View full text Add to dashboard Cite

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“…Several strategies to build trust within the community were discussed at the Workshop as well as have been published in the literature. Suggestions include formation of a community advisory board to receive community input, use of the perspectives of community members and research participants to guide recruitment strategies, collaborations with area organizations to develop relationships, providing an unmet need to the community, educating care providers about dementia and treatments, encouraging a positive and welcoming attitude among all who will work with participants, and acknowledging the potential stigma of ADRD 57,61,62 . Active engagement in and with the community requires showing up often and motivating community members to engage in all aspects of the research process.…”

Section: Workhop Recommendationsmentioning

confidence: 99%

Perspective on the “African American participation in Alzheimer disease research: Effective strategies” workshop, 2018

Denny¹,

Streitz²,

Stock

et al. 2020

Alzheimer's & Dementia

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to address a major limitation of the ongoing scientific progress regarding Alzheimer's disease and related dementias (ADRD): participants in most ADRD research programs overwhelmingly have been limited to non-Hispanic white persons, thus precluding knowledge as to how ADRD may be represented in nonwhite individuals. Factors that may contribute to successful recruitment and retention of African Americans into ADRD research were discussed and organized into actionable next steps as described within this report.

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“…Referrals from trusted friends, family members, or physicians has been shown to positively influence participation in clinical research [16,23]. Additionally, research participants who previously underwent an LP or knew someone who did so were more likely to agree to undergo the procedure [10], indicating that comfort with the procedure may positively influence participation.…”

Section: Analysis Of Factors Associated With Baseline Lp Participationmentioning

confidence: 99%

Factors Associated with Lumbar Puncture Participation in Alzheimer’s Disease Research

Blazel¹,

Lazar²,

Hulle³

et al. 2020

JAD

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Background: Cerebrospinal fluid (CSF) provides insight into the spectrum of Alzheimer’s disease (AD) pathology. While lumbar punctures (LPs) for CSF collection are generally considered safe procedures, many participants remain hesitant to participate in research involving LPs. Objective: To explore factors associated with participant willingness to undergo a research LP at baseline and follow-up research study visit. Methods: We analyzed data from 700 participants with varying cognition (unimpaired, mild cognitive impairment, and dementia) in the Wisconsin Alzheimer’s Disease Research Center. We evaluated the relationship of demographic variables (age, sex, race, ethnicity, and years of education) and clinical variables (waist-to-hip ratio, body mass index, AD parental history, cognitive diagnosis) on decision to undergo baseline LP1. We evaluated the relationship of prior LP1 experience (procedure success and adverse events) with the decision to undergo follow-up LP2. The strongest predictors were incorporated into regression models. Results: Over half of eligible participants opted into both baseline and follow-up LP. Participants who underwent LP1 had higher mean education than those who declined (p = 0.020). White participants were more likely to choose to undergo LP1 (p < 0.001); 33% of African American participants opted in compared to 65% of white participants. Controlling for age, education, and AD parental history, race was the only significant predictor for LP1 participation. Controlling for LP1 mild adverse events, successful LP1 predicted LP2 participation. Conclusion: Race was the most important predictor of baseline LP participation, and successful prior LP was the most important predictor of follow-up LP participation.

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Best strategies to recruit and enroll elderly Blacks into clinical and biomedical research

Cited by 28 publications

References 32 publications

Reframing implementation science to address inequities in healthcare delivery

Reframing implementation science to address inequities in healthcare delivery

Perspective on the “African American participation in Alzheimer disease research: Effective strategies” workshop, 2018

Factors Associated with Lumbar Puncture Participation in Alzheimer’s Disease Research

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