2024
DOI: 10.1007/s12672-024-01063-4
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Bestatin attenuates breast cancer stemness by targeting puromycin-sensitive aminopeptidase

Yan Ma,
Xintong Yang,
Pengge Pan
et al.

Abstract: Breast cancer is a prevalent malignant tumor among women with an increasing incidence rate annually. Breast cancer stem cells (BCSCs) are integral in impeding tumor advancement and addressing drug resistance. Bestatin serves as an adjuvant chemotherapy, triggering apoptosis in cancer cells. In this study, the effects of bestatin on sorted BCSCs from breast cancer cell lines have been studied. Our results indicated that bestatin inhibits the migration and proliferation of breast cancer cells by reducing the ste… Show more

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