Beta-2-microglobulin and ferritin in cerebrospinal fluid for evaluation of patients with meningitis of different etiologies

Takahashi, Satoru; Oki, Junichi; Miyamoto, Akie; Moriyama, Takanori; Asano, Akiko; Inyaku, F; Okuno, Akimasa

doi:10.1016/s0387-7604(99)00017-0

Cited by 24 publications

(25 citation statements)

References 23 publications

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“…Hospitalized patients in our study were adults with age range of 19-85 years whereas previously mentioned studies have mostly been carried out on children. Ferritin cutoff points obtained in our study were similar to other studies (Katnik, 1995 andTakahashi et al, 1999;YO et al, 2003;Lac et al, 2003;Rahimy et al, 1998). Sensitivity and specificity of ferritin cutoff point was different in our study compared to the other studies (Takahashi et al, 1999;YO et al, 2003;Lac et al, 2003;Rahimy et al, 1998;Katnik, 1995).…”

Section: Discussionsupporting

confidence: 91%

“…Ferritin cutoff points obtained in our study were similar to other studies (Katnik, 1995 andTakahashi et al, 1999;YO et al, 2003;Lac et al, 2003;Rahimy et al, 1998). Sensitivity and specificity of ferritin cutoff point was different in our study compared to the other studies (Takahashi et al, 1999;YO et al, 2003;Lac et al, 2003;Rahimy et al, 1998;Katnik, 1995). Low specificity of cerebrospinal fluid ferritin in our study was similar to the study of Sato et al (1998) and Hallgren et al (1982).…”

Section: Discussionsupporting

confidence: 91%

“…In this study cerebrospinal fluid ferritin was higher in the patients with bacterial meningitis compared to the patients with aseptic meningitis which were similar to the results of a study carried out (Takahashi et al, 1999;YO et al, 2003;Lac et al, 2003;Rahimy et al, 1998).…”

Section: Discussionsupporting

confidence: 91%

“…At the time being there is no clinical or laboratory diagnostic method which can solely prove or disprove bacterial meningitis instantly and accurately in patients with pleocytosis in cerebrospinal fluid and most methods used for diagnosing bacterial meningitis are associated with serious limitations (Takahashi et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Takahashi et al (1999) also evaluated cerebrospinal fluid ferritin and β2 microglobuline in patients with meningitis caused by different etiologies. Cutoff point degree of ferritin was 7.5 µg −1 L in five children with bacterial meningitis which was confirmed by positive culture with a sensitivity of 100% and specificity of 78%.…”

Section: Discussionmentioning

confidence: 99%

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Cerebrospinal Fluid Ferritin for Differentiation of Aseptic and Bacterial Meningitis in Adults

Makoo¹,

Ahadi²,

Hasani³

et al. 2010

American Journal of Infectious Diseases

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Problem statement:Bacterial meningitis is one of the most important causes of mortality and morbidity. Rapid diagnosis of bacterial cause is very important and critical, because early antibiotic therapy prevents complications; different tests have been developed for rapid diagnosis of bacterial meningitis. One of them is CSF ferritin, which is evaluated in this study. Approach: During cross sectional study from 2008-2009 for 2 years, CSF was collects from 61 adults suspected to have meningitis. These patients admitted to Emam Reza and Sina hospitals of Tabriz. CSF was analyzed for ferritin, glucose, protein, cell count, culture and gram stains. Clinical data's were collected for all patients. Collected data's were analyzed by SPSS software. Results: From 61 specimens, 19 cases had bacterial, 19 cases had aseptic meningitis and 23 cases had no criteria for diagnosis of meningitis. CSF ferritin in bacterial meningitis was 231.63 ± 61.26 ng dL −1 that was significantly higher, than that of aseptic meningitis group. Cut off value for ferritin was estimated 155ng dL −1 with sensitivity of 94% and specificity of 21.7% in this study. Symptoms such as levels of consciousness, fever and seizure were not considered as a criteria for diagnosis of bacterial meningitis (p>0.05). But symptoms such as headache, nausa, vomiting and neck stefness were significantly higher in bacterial and aseptic groups than no meningitis group (p<0.05). Conclusion: In this study CSF ferritin in bacterial meningitis group was significantly higher than aseptic meningitis group. But due to low specificity of CSF ferritin for differentiation of bacterial from aseptic meningitis, we don't recommend performance of this test in early phase of meningitis course.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Cerebrospinal Fluid Ferritin for Differentiation of Aseptic and Bacterial Meningitis in Adults

Makoo¹,

Ahadi²,

Hasani³

et al. 2010

American Journal of Infectious Diseases

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Cerebrospinal fluid ferritin in chronic hydrocephalus after aneurysmal subarachnoid hemorrhage

Suzuki

Muramatsu²,

Tanaka

et al. 2006

J Neurol

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This is the first study to show that patients who subsequently had chronic hydrocephalus requiring CSF shunting were associated with higher CSF levels of ferritin in the acute stage of SAH. Higher CSF ferritin levels may not reflect the amount of blood in the subarachnoid space that was intracranially metabolized, but rather more intense subarachnoid inflammatory reactions which may cause chronic hydrocephalus after SAH.

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Beta2-microglobulin concentrations in cerebrospinal fluid correlate with neuroimaging findings in newborns with symptomatic congenital cytomegalovirus infection

et al. 2006

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CSF beta(2)-m was increased in newborns with CMV infection (median 6.21 mg/L) compared with controls (1.68 mg/L) (P<.001). beta(2)-m showed a correlation with neuroimaging scores (r (s)=0.753, P=.002). beta(2)-m was higher in patients who scored 2-3 (12.83 mg/L) than in patients who scored 0-1 (5.52 mg/L) (P=.028). CSF beta(2)-m is increased in newborns with symptomatic congenital CMV infection and correlates with neuroimaging abnormalities. beta(2)-m appears to be an indicator of the severity of brain involvement in congenital CMV infection.

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Beta-2-microglobulin and ferritin in cerebrospinal fluid for evaluation of patients with meningitis of different etiologies

Cited by 24 publications

References 23 publications

Cerebrospinal Fluid Ferritin for Differentiation of Aseptic and Bacterial Meningitis in Adults

Cerebrospinal Fluid Ferritin for Differentiation of Aseptic and Bacterial Meningitis in Adults

Cerebrospinal fluid ferritin in chronic hydrocephalus after aneurysmal subarachnoid hemorrhage

Beta2-microglobulin concentrations in cerebrospinal fluid correlate with neuroimaging findings in newborns with symptomatic congenital cytomegalovirus infection

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