Beta-adrenergic effects on rat myometrium: role of cyclic AMP

Kroeger, E A; Marshall, Janice M.

doi:10.1152/ajplegacy.1974.226.6.1298

Cited by 48 publications

(21 citation statements)

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“…Catecholamines may cause relaxations of some smooth muscles (8)(9)(10)(11)(12)(13)(14), some vascular smooth muscles (8,(15)(16)(17), uterus (8,(18)(19)(20)(21)(22)(23). The action of catecholamines son these muscles is mainly due to beta-adrenoceptor activation and able to be blocked by beta-adrenergic blocking agents (12-14, 17, 19).…”

Section: And Discussionmentioning

confidence: 99%

“…The action of catecholamines son these muscles is mainly due to beta-adrenoceptor activation and able to be blocked by beta-adrenergic blocking agents (12-14, 17, 19). Cyclic adenosine-3', 5'-monosphosphate (cyclic AMP) is believed to be the intracellular mediator of the effect of beta-adrenoceptor activation in the smooth muscles mentioned above (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). On the other hand, alpha-adrenoceptor activation may also cause relaxation of intestinal smooth muscle (9,(12)(13)(14).…”

Section: And Discussionmentioning

confidence: 99%

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Effect of Rutin on the Isolated Rat Duodenum and Comparison with the Effects of Adrenaline, Isoprenaline and Papaverine

Altinkurt¹,

Öztürk²

2008

Ankara Universitesi Eczacilik Fakultesi Dergisi

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SUMMARYThe experiments were performed by using isolated rat duodenum. Rutin, a natural flavonoid compound, caused relaxations of the rat duodenum dose-dependently. The relaxant effect of rutin on the rat duodenum was examined in comparison with that of adrenaline, isoprenaline and papaverine. In addition, propranolol, a beta-adrenergic blocking agent, phentolamine, an alpha-adrenergic blockingagent and nicotinic acid, an adenyl cyclase inhibitor were used as tools to investigate mechanism of the relaxant effect of rutin on the rat duodenum in vitro. ÖZETDeneyler izole sıçan duodenumu kullanılarak sürdürüldü. Doğal bir flavonoid bileşiği olan rutin doza bağımlı biçimde sıçan duodenumunu gevşetti. Rutin'in sıçan duodenumundaki gevşetici etkisi adrenalin, izoprenalin ve papaverin ile karşılaştırmalı olarak incelendi. Ayrıca, rutin'in sıçan duodenumundaki gevşetici etkisinin mekanizmasını araştırmak için beta-adrenerjik bloker olan propranolol, alfaadrenerjik bloker olan fentolamin ve bir adenil siklaz inhibitörü olan nikotinik asid de kullanıldı.

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Section: And Discussionmentioning

confidence: 99%

Section: And Discussionmentioning

confidence: 99%

Effect of Rutin on the Isolated Rat Duodenum and Comparison with the Effects of Adrenaline, Isoprenaline and Papaverine

Altinkurt¹,

Öztürk²

2008

Ankara Universitesi Eczacilik Fakultesi Dergisi

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“…Ortamda agonist madde bulunduğu sürece sitoplazmada siklik AMP birikimi olur, siklik AMP (Adenozin monofosfat) Beta adrenerjik aktivasyonda hücre içi olaylarda ikinci ulak (sekonder messenger) görevi yapar (5,16,21,24,38).…”

Section: Introductionunclassified

“…Beta-adrenerjik res eptörlerin aktivasyonunda hücre içi kalsiyum yoğunluğu azalır (19,24,28 Grafik: 5 ve 6 Mg varlıgı ve yoklugunda Dibutiril siklik AMP'nin potasyum kontraksiyonundakietkilerine ait dozeCevap ilişkisi Grafik: 3.5 ostrojen, 3.6 ise progesteron uygulanmış tavşanlardan alınan test dokularındaki sonuçları göstermektedir. …”

Section: Introductionunclassified

ıN VıTRO ORTAMDA SEMPATOMİMETıK iLAÇLARıN BETA ADRENERJİK RESEPTÖR AKTıV ASYONLARINA Mg VE Ca İYONLARıNIN ETKıLERı üZERİNE ARAŞTIRMALAR

Liman¹

1991

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…Since Bueding, Butcher, Hawkins, Timms & Sutherland (1966) suggested that this effect was related to activation of adenyl cyclase, many investigators have shown that the cyclic AMP level in smooth muscle is directly related to smooth muscle tone, i.e. increase in cyclic AMP causes relaxation of visceral smooth muscle (Andersson, Lundholm, Mohme-Lundholm & Nilsson, 1972;Schultz, Schultz & Hardman, 1975;Bar, 1974;Kroeger & Marshall, 1974;Triner, Nahas, Vullienoz, Overweg, Verosky, Habif & Ngai, 1975;Kroeger, Teo, Ho & Wang, 1975;Honeyman, Merrian & Fay, 1978). This postulation has been confirmed and extended by further investigations.…”

mentioning

confidence: 99%

Does activation of cyclic AMP dependent phosphorylation induced by beta‐adrenergic agent control the tone of vascular muscle?

Hirata¹,

Kuriyama²

1980

The Journal of Physiology

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SUMMARY1. The relaxing action of the f3-adrenergic agent, isoprenaline, on the porcine coronary artery was investigated in relation to the cyclic AMP level, the endogenous binding of cyclic AMP to the regulatory unit of cyclic AMP dependent protein kinase or the phosphorylation as a result of activation of protein kinase of the muscle homogenate in Krebs solution and excess [K]o solution. These relations were also compared with those of the rat cardiac muscle, in which isoprenaline showed a positive inotropic action.2. Excess [K]0 decreased the cyclic AMP level in proportion to the amplitude of K-induced contracture in the porcine coronary artery. Isoprenaline increased the cyclic AMP level in Krebs solution, while it had no effect in excess [K]o.3. In the porcine coronary artery, the particulate fraction possessed only 5 % of the total cyclic AMP dependent protein kinase, while in the rat cardiac muscle, the particulate fraction was 25 % of the total protein kinase.4. The cyclic AMP dependent protein kinase in the particulate fraction of the porcine coronary artery was already saturated with the endogenous cyclic AMP. However, the binding of cyclic AMP to the protein kinase in the particulate fraction in the cardiac muscle and in the cytosol fraction of both tissues were increased in accordance with the cyclic AMP level. In the coronary artery, the protein kinase in the cytosol fraction was bound to a greater extent with cyclic AMP than was measured in the rat cardiac muscle.5. In the rat cardiac muscle, isoprenaline enhanced the phosphorylation, detected by autoradiography of SDS gel electrophoresis in individual fractions of phosphorylated protein, while little enhancement was observed in the porcine coronary artery. 6. These observations led to the conclusion that in the porcine coronary artery, fl-adrenergic agent increases the levels of cyclic AMP but does not increase the phosphorylation. If the phosphorylation catalyzed by cyclic AMP dependent protein kinase was utilized for Ca mobilization in the cell, the change in the cyclic AMP level would probably not have a causal relation to the muscle tone. This conclusion, however, may not be applicable in the case of the cardiac muscle.

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Beta-adrenergic effects on rat myometrium: role of cyclic AMP

Cited by 48 publications

References 0 publications

Effect of Rutin on the Isolated Rat Duodenum and Comparison with the Effects of Adrenaline, Isoprenaline and Papaverine

Effect of Rutin on the Isolated Rat Duodenum and Comparison with the Effects of Adrenaline, Isoprenaline and Papaverine

ıN VıTRO ORTAMDA SEMPATOMİMETıK iLAÇLARıN BETA ADRENERJİK RESEPTÖR AKTıV ASYONLARINA Mg VE Ca İYONLARıNIN ETKıLERı üZERİNE ARAŞTIRMALAR

Does activation of cyclic AMP dependent phosphorylation induced by beta‐adrenergic agent control the tone of vascular muscle?

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