1996
DOI: 10.1007/bf02253709
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Beta-adrenergic mechanisms in arterial hemodynamics: A comparison between normotensive and hypertensive rats

Abstract: The purpose of this study was to determine whether beta-adrenergically mediated cardiovascular functions such as arterial pressure (AP), heart rate (HR), stroke volume (SV), cardiac output (CO), peripheral resistance (R(p)), arterial impedance (Z(c)), mean arterial compliance (C(m)) and pulse wave reflection (P(b)) were altered in the spontaneously hypertensive rat (SHR) compared to the normotensive Wistar Kyoto rat (WKY). In pentobarbital-anesthetized and artificially ventilated rats, the aortic pressure wave… Show more

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Cited by 7 publications
(3 citation statements)
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“…We have not investigated the effects of adrenergic blockers under normoxic conditions as this was not the principal focus of this study. Comparison of our results with existing data on the effects of adrenergic blockers on cardiovascular function in normoxic rats (e.g., [ 20 , 49 ]) indicated differences that are attributable to hypoxia.…”
Section: Discussionsupporting
confidence: 74%
See 1 more Smart Citation
“…We have not investigated the effects of adrenergic blockers under normoxic conditions as this was not the principal focus of this study. Comparison of our results with existing data on the effects of adrenergic blockers on cardiovascular function in normoxic rats (e.g., [ 20 , 49 ]) indicated differences that are attributable to hypoxia.…”
Section: Discussionsupporting
confidence: 74%
“…TPR remained on the low level of hypoxic controls. This response to hypoxia plus β-adrenergic blockade was completely different from that observed under normoxic conditions: In healthy normoxic Wistar-Kyoto rats, injection of propranolol did not significantly reduce or even slightly increased systolic pressure [ 20 , 24 ]. Adrenergic blockade in normoxia primarily modulated TPR leading to secondary changes in arterial pressure [ 49 ], while in hypoxia, TPR was rather insensitive to adrenergic blockers.…”
Section: Discussionmentioning
confidence: 99%
“…The technique of arterial impedance analysis has been developed for the complete assessment of arterial haemodynamics and quantitation of ventricular afterload (O'Rourke & Taylor, 1967;Milnor, 1975;Nicholas et al, 1977;O'Rourke, 1982) and utilized extensively in recent years (Zuckerman & Yin, 1989;Chang et al, 1990Chang et al, , 1994Hu et al, 1994Hu et al, , 1996Chen et al, 1996). Its purpose is to analyse the instaneous relation between aortic pressure and¯ow through Fourier transform (frequency analysis) of the phasic pressure and¯ow waves.…”
Section: Introductionmentioning
confidence: 99%