Beta-Adrenergic Receptors Gene Polymorphisms are Associated With Cardiac Contractility and Blood Pressure Variability

Abstract

β-adrenergic receptors (β-ARs) play a pivotal role in the cardiovascular regulation. In the human heart β1- and β2-ARs dominate in atria as well as in ventricle influencing heart rate and myocardial contractility. Some single nucleotide polymorphisms (SNPs) of β-ARs might influence cardiovascular function. However, the influence of β-AR genes SNPs on hemodynamic parameters at rest and their reactivity under stress is still not well known. We aimed to explore the associations between four selected β-ARs gene polymorphisms and selected cardiovascular measures in eighty-seven young healthy subjects. While in β1-AR polymorphism rs1801252 no significant association was observed, second β1-AR polymorphism rs1801253 was associated with decreased cardiac output and cardiac index during all phases and with decreased flow time corrected and ejection time index at rest and during mental arithmetics. Polymorphism rs1042713 in β2-AR was associated with alterations in blood pressure variability at rest and during head-up-tilt, while rs1042714 was associated predominantly with decreased parameters of cardiac contractility at rest and during mental arithmetics. We conclude that complex analysis of various cardiovascular characteristics related to the strength of cardiac contraction and blood pressure variability can reveal subtle differences in cardiovascular sympathetic nervous control associated with β-ARs polymorphisms.

The Effects of Cobra Cardiotoxins on the Papillary Muscle and Langendorf Perfused Rat Heart Are Not Associated With Adrenaline Release

“…1Д), соответственно, что существенно отличается от эффекта изопротеренола, который вызывает ускорение ВДМ со 106±5 до 89±4 мс, ВР50% с 58±6 до 43±4 мс и ВР95% с 145±15 до 90±14мс. Известно, что большую часть адренорецепторов в сердце составляет β подтип, активация которого ведет к положительному инотропному и хронотропному эффектам, а также к отрицательному лузитропному эффекту [10]. Поскольку в нашей работе частота сокращений задается стимуляцией, то можно сопоставить эффекты по силе и временным параметрам сокращения.…”

β2-AR inhibition enhances EGFR antibody efficacy hampering the oxidative stress response machinery

“…In fact, the β2-adrenergic receptor regulates ER–mitochondria contacts, being a regulatory pathway for ER–Mito coupling, and these contacts respond to physiological demands or stresses [ 2 , 3 ]. On the other hand, Beta-adrenergic receptor gene polymorphisms are associated with cardiac contractility and blood pressure variability [ 4 ]. The key role of the β2-AR signaling in cancer biology has been initially demonstrated in epidemiological studies that correlated chronic stress with accelerated tumor progression [ 5 , 6 ], as well as reduced tumor aggressiveness in patients under β-blockers therapy [ 7 , 8 ].…”