beta‐Adrenoceptor‐blocking agents and the kidney: effect of nadolol and propranolol on the renal circulation.

Abstract

1 Nadolol was administered intravenously to five hypertensive patients and three healthy volunteers in balance on a 10 mEq sodium intake. 2 Nadolol (0.3-10.0,ug/kg) induced a significant, dose-related increase in renal blood flow, measured with radioxenon, with a maximum increase of 72 ± 4 ml/100g/min (26%) at 3.0 .g/kg. 3 Heart rate and plasma renin activity decreased significantly over the same dose range. 4 The renal vascular response to nadolol contrasts sharply with those found with other P-adrenoceptor-blocking agents.5 The magnitude ofthe increase in renal blood flow, its time-course and the parallel fall in plasma renin activity raise the possibility that the renal vasodilatation reflects the reversal of angiotensin's influence on the renal arterial bed.

Beta-bloqueadores em anestesiologia: aspectos farmacológicos e clínicos

“…The same is not true for those with such activity. The same is true for renal 17 and brain circulation. Propranolol decreases hepatic artery and portal vein blood flow in liver circulation.…”

“…O inverso ocorre com os que apresentam essa atividade. O mesmo ocorre em relação à circulação renal 17 e cerebral. Na circulação hepática, o propranolol diminui o fluxo sangüíneo da artéria hepática e da veia porta.…”

“…A seletividade em beta 1 e a atividade simpaticomimética intrínseca diminuem a atividade broncoconstritora dos beta-bloqueadores 18 . A ação dos beta-bloqueadores sobre a função renal é variá-vel na dependência de efeitos diretos e indiretos, podendo aumentar, manter ou diminuir a diurese 17 . Diminuem a pressão intra-ocular em pacientes com glaucoma 19 e também os níveis plasmáticos de angiotensina e de aldosterona, a secreção de glucagon em resposta à hipoglicemia fisiológica e a glicogenólise.…”

Antihypertensive and renal haemodynamic effects of atenolol and nadolol in elderly hypertensive patients.

“…Similar effects have been reported with oxprenolol (Bufano & Piacentini, 1969), pindolol (Heierli et al, 1972) and acebutalol (Dreslinski et al, 1981). In contrast, nadolol has been observed to increase renal blood flow, when administered intravenously (Hollenberg et al, 1979a) and in chronic use renal blood flow is maintained in the face of diminished cardiac output (Textor et al, 1982). B3-adrenoceptor blockers have a direct effect on renal blood flow when administered in doses insufficient to produce systemic haemodynamic changes (Carriere, 1969;Sullivan et al, 1976).…”

A study of the effects of atenolol and propranolol on renal function in patients with essential hypertension.

“…Hollenberg, Adams, McKinstry, Williams, Borucki & Sullivan (1979) have demonstrated an increase in renal blood flow in salt depleted patients given the non-cardioselective fl-adrenoceptor blocking drug, nadolol. They are not able to fully explain this but suggest that the increase may be due to inhibition of renin release coupled possibly with a direct vasodilating action of the drug.…”