Beta-band power modulation in the human hippocampus during a reaching task

Campo-Vera, Roberto Martin Del; Gogia, Angad S.; Chen, Kuang-Hsuan; Sebastian, Rinu; Kramer, Daniel R.; Lee, Morgan B.; Peng, Terrance; Tafreshi, Ali; Barbaro, Michael F.; Liu, Charles; Kellis, Spencer; Lee, Brian

doi:10.1088/1741-2552/ab937f

Cited by 11 publications

(13 citation statements)

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“…Previous studies from our group utilized stereotactic electroencephalography (SEEG) to characterize the relationship between the hippocampal beta band and motor output. Like prior non-hippocampal motor studies [17,18], we found decreases in hippocampal beta band power during the motor response phase compared with the fixation phase in a simple reaching task [19]. In a separate study, we examined beta power in the hippocampus during a Go/No-Go (GNG) task.…”

Section: Introductionsupporting

confidence: 55%

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Baseline hippocampal beta band power is lower in the presence of movement uncertainty

et al. 2022

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Objective This study aimed to characterize hippocampal neural signatures of uncertainty by measuring beta band power in the period prior to movement cue. Approach Participants with epilepsy were implanted with hippocampal depth electrodes for stereo electroencephalographic (SEEG) monitoring. Hippocampal beta (13-30 Hz) power changes have been observed during motor tasks such as the direct reach (DR) and Go/No-Go (GNG) tasks. The primary difference between the tasks is the presence of uncertainty about whether movement should be executed. Previous research on cortical responses to uncertainty has found that baseline beta power changes with uncertainty. SEEG data were sampled throughout phases of the DR and GNG tasks. Beta-band power during the fixation phase was compared between the DR and GNG task using a Wilcoxon rank sum test. This unpaired test was also used to analyze response times from cue to task completion between tasks. Main Results Eight patients who performed both reaching tasks were analyzed in this study. Movement response times in the GNG task were on average 210 milliseconds slower than in the DR task. All patients exhibited a significantly increased response latency in the GNG task compared to the DR task (Wilcoxon rank-sum p-value < 0.001). Six out of eight patients demonstrated statistically significant differences in beta power in single hippocampal contacts between the fixation phases of the GNG and DR tasks. At the group level, baseline beta power was significantly lower in the GNG task than in the DR task (Wilcoxon rank-sum p-value < 0.001). Significance This novel study found that, in the presence of task uncertainty, baseline beta power in the hippocampus is lower than in its absence. This finding implicates movement uncertainty as an important factor in baseline hippocampal beta power during movement preparation.

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Section: Introductionsupporting

confidence: 55%

“…Beta activity during the response phase of a GNG task signifies reactive motor inhibition (in response to the GNG cue) [19,20]. On the other hand, beta activity before the response phase of a GNG task (i.e.…”

Section: Introductionmentioning

confidence: 99%

Baseline hippocampal beta band power is lower in the presence of movement uncertainty

et al. 2022

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“…The beta band has been well studied throughout the motor system where it has been observed in the motor cortex, pre-motor cortex, basal ganglia, cerebellum, peripheral nervous system, and hippocampus [41,50,51], typically with a significant decrease in power during voluntary movements [42,51,67,68]. Conversely, in pathologic neurologic and motor conditions such as Parkinson's disease, motor system inhibition is associated with an increase in the betaband power [41,42].…”

Section: Discussionmentioning

confidence: 99%

“…The beta-band frequency has been the subject of multiple investigations in motor [41][42][43][44][45][46] and attentional control [47][48][49]. In the motor cortex, pre-motor cortex, basal ganglia, cerebellum, peripheral nervous system, and hippocampus [41,50,51], significant decreases in beta-band power have been observed during voluntary movement. In addition to its role in the motor system, the beta band has been widely studied in attentional control.…”

Section: Introductionmentioning

confidence: 99%

Beta-band modulation in the human hippocampus during a conflict response task

et al. 2020

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Objective. Identify the role of beta-band (13–30 Hz) power modulation in the human hippocampus during conflict processing. Approach. We investigated changes in the spectral power of the beta band (13–30 Hz) as measured by depth electrode leads in the hippocampus during a modified Stroop task in six patients with medically refractory epilepsy. Previous work done with direct electrophysiological recordings in humans has shown hippocampal theta-band (3–8 Hz) modulation during conflict processing. Local field potentials sampled at 2 k Hz were used for analysis and a non-parametric cluster-permutation t-test was used to identify the time period and frequency ranges of significant power change during cue processing (i.e. post-stimulus, pre-response). Main results. In five of the six patients, we observe a statistically significant increase in hippocampal beta-band power during successful conflict processing in the incongruent trial condition (cluster-based correction for multiple comparisons, p < 0.05). There was no significant beta-band power change observed during the cue-processing period of the congruent condition in the hippocampus of these patients. Significance. The beta-power changes during conflict processing represented here are consistent with previous studies suggesting that the hippocampus plays a role in conflict processing, but it is the first time that the beta band has been shown to be involved in humans with direct electrophysiological evidence. We propose that beta-band modulation plays a role in successful conflict detection and automatic response inhibition in the human hippocampus as studied during a conflict response task.

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“…We analyzed PAC changes between baseline and cue presentation in stimulus-locked segments (200-800 ms after cue onset [2,44]) in both congruent and incongruent conditions for each patient. We found that five out of eight patients (the identical patients who showed significant increased theta-LG PAC values from baseline in the OFC during successful trials of the incongruent condition) showed increased theta-LG PAC values from baseline in the OFC during successful trials of the incongruent condition (cluster-based permutation t-test, p < 0.05).…”

Section: Theta-lg Pac Increasesmentioning

confidence: 99%

Theta low-gamma phase amplitude coupling in the human orbitofrontal cortex increases during a conflict-processing task

Chen¹,

Tang²,

Gilbert³

et al. 2022

J. Neural Eng.

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Introduction The human orbitofrontal cortex (OFC) is involved in automatic response inhibition and conflict processing, but the mechanism of frequency-specific power changes that control these functions is unknown. Theta and gamma activity have been independently observed in the OFC during conflict processing, while theta-gamma interactions in other brain areas have been noted primarily in studies of memory. Within the OFC, it is possible that theta-gamma phase amplitude coupling (PAC) drives conflict processing. Objective This study aims to characterize the coupled relationship between theta and gamma frequency bands in the OFC during conflict processing using a modified Stroop task. Methods Eight epilepsy patients implanted with OFC stereotactic electroencephalography (SEEG) electrodes participated in a color-word modified Stroop task. PAC between theta phase and gamma amplitude was assessed to determine the timing and magnitude of neural oscillatory changes. Group analysis was conducted using a non-parametric cluster-permutation t-test on coherence values. Results Theta-low gamma (LG) PAC significantly increased in five out of eight patients during successful trials of the incongruent condition compared with the congruent condition. Significant increases in theta-LG PAC were most prominent during cue processing 200-800ms after cue presentation. On group analysis, trial-averaged mean theta-LG PAC was statistically significantly greater in the incongruent condition compared to the congruent condition (p < 0.001, Cohen’s d=0.51). Conclusion For the first time, we report that OFC theta phase and LG amplitude coupling increases during conflict resolution. Given the delayed onset after cue presentation, OFC theta-LG PAC may contribute to conflict processing after conflict detection and before motor response. This explanation follows the hypothesis that global theta waves modulate local gamma signals. Understanding this relationship within the OFC will help further elucidate the neural mechanisms of human conflict resolution.

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Beta-band power modulation in the human hippocampus during a reaching task

Cited by 11 publications

References 50 publications

Baseline hippocampal beta band power is lower in the presence of movement uncertainty

Baseline hippocampal beta band power is lower in the presence of movement uncertainty

Beta-band modulation in the human hippocampus during a conflict response task

Theta low-gamma phase amplitude coupling in the human orbitofrontal cortex increases during a conflict-processing task

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