Beta Blockers and Lactation: An Update

Shannon, Meghan E.; Malecha, Susan E.; J., Amy

doi:10.1177/089033440001600313

Cited by 13 publications

(13 citation statements)

References 23 publications

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“…1). Shannon et al [20] reported the excretion of several beta blockers into breast milk. The authors reported that, on an average, milk- Table 3 Pharmacokinetic parameters of pindolol enantiomers in parturient women (n = 6) treated with multiple doses of racemic pindolol ( to-serum concentrations ranged from 3.0 to 3.5 for metoprolol, 4.6 for sotalol, 2.7 for nadolol, from 2.0 to 11.6 for betaxolol, 2.0 for propranolol, and from 1.1 to 3.1 for atenolol.…”

Section: Resultsmentioning

confidence: 99%

Determination of pindolol enantiomers in amniotic fluid and breast milk by high-performance liquid chromatography: Applications to pharmacokinetics in pregnant and lactating women

Gonçalves

Cavalli

Cunha

et al. 2007

Journal of Chromatography B

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Section: Resultsmentioning

confidence: 99%

Determination of pindolol enantiomers in amniotic fluid and breast milk by high-performance liquid chromatography: Applications to pharmacokinetics in pregnant and lactating women

Gonçalves

Cavalli

Cunha

et al. 2007

Journal of Chromatography B

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“…115,116 Although symptoms caused by β-blockade (such as brady cardia and hypoglycaemia) have not previously been reported following exposure to propranolol or metoprolol via milk, some authors nevertheless recommend that exposed infants should be closely observed for these signs. 117 Even though such effects perhaps could be an issue in preterm infants or newborns, we consider it unlikely that any such pharmacological effect would arise in a breastfed infant.…”

Section: Ergot Alkaloidsmentioning

confidence: 93%

Pharmacological treatment of migraine during pregnancy and breastfeeding

et al. 2015

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Migraine affects up to 25% of women of reproductive age. In the majority of these women, migraine improves progressively during pregnancy, but symptoms generally recur shortly after delivery. As suboptimally treated migraine in pregnancy could have negative consequences for both mother and fetus, the primary aim of clinicians should be to provide optimal treatment according to stage of pregnancy, while minimising possible risks related to drug therapy. Nonpharmacological approaches are always first-line treatment, and should also be used to complement any required drug treatment. Paracetamol is the preferred drug for acute treatment throughout pregnancy. If paracetamol is not sufficiently effective, sporadic use of sumatriptan can be considered. NSAIDs such as ibuprofen can also be used under certain circumstances, though their intake in the first and third trimesters is associated with specific risks and contraindications. Preventive treatment should only be considered in the most severe cases. In women contemplating pregnancy, counselling is essential to promote a safe and healthy pregnancy and postpartum period for the mother and child, and should involve a dialogue addressing maternal concerns and expectations about drug treatment. This Review summarizes current evidence of the safety of the most common antimigraine medications during pregnancy and breastfeeding, and provides treatment recommendations for use in clinical practice.

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“…[34] β-blockers are suggested as first-choice medications during lactation if migraine prophylaxis is considered. [41] Propranolol is excreted into breast milk, but the amounts are considerably lower. Although symptoms caused by β-blockade (such as bradycardia and hypoglycaemia) have not previously been reported following exposure to propranolol or metoprolol via milk, some authors nevertheless recommend that exposed infants should be closely observed for these signs.…”

Section: β-Blockersmentioning

confidence: 99%

Headache in Challenging and Special Circumstances: Pregnancy and Lactation

Yılmaz¹,

Çevik

2018

Agri

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ÖzetGebelik ve doğum sonrası dönemdeki baş ağrıları özel bir önem taşımaktadır. Bu dönemdeki baş ağrısı yönetimi sağlık çalışanları ve hastalar tarafından zorlayıcı olarak bildirilmektedir. Başağrısına doğru yaklaşım hem anne hem de fetal/yenidoğan risklerinin önlenmesi açısından önemlidir. İlk trimesterdeki baş ağrılarının büyük çoğunluğu primer baş ağrıları grubundadır. Gebeliğin son trimesteri ve doğum sonrası dönemlerde, sekonder baş ağrılarının sıklığı ise artmaktadır. Baş ağrısı hastalarında kırmızı bayrak belirti ve bulgularına dikkat edilmelidir. Baş ağrısı hastasının değerlendirilmesinde detaylı anamnez alınması; doğru ve eksiksiz olarak fizik ve nörolojik muayene yapılması yanında gerekirse ileri tetiklerin yapılması da önemlidir. Bu derlemede gebelik ve laktasyon dönemindeki baş ağrılarına yaklaşım ve en iyi medikal uygulama stratejileri gözden geçirilmektedir. Anahtar sözcükler: Tanı; migren; primer baş ağrıları; kırmızı bayrak bulguları; sekonder baş ağrıları; tedavi. SummaryHeadache has special importance during pregnancy and postpartum period. The health-care professionals and patients report headache management as challenging during pregnancy and lactation period. Cautions are recommended in preganancy and lactation due to maternal and fetal/newborn risks. Most headaches in the first trimester are due primary headaches. Nevertheless, the incidence of secondary headaches increase in the last trimester and post-partum period. Red flags prompt early evaluation in a patient with headache. Assessment of headache patient requires a detailed history of the headache characteristics and performing appropriate examinations. Approach to headache and strategies to promote best practice in preganancy and lactation will be reviewed.

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Beta Blockers and Lactation: An Update

Cited by 13 publications

References 23 publications

Determination of pindolol enantiomers in amniotic fluid and breast milk by high-performance liquid chromatography: Applications to pharmacokinetics in pregnant and lactating women

Determination of pindolol enantiomers in amniotic fluid and breast milk by high-performance liquid chromatography: Applications to pharmacokinetics in pregnant and lactating women

Pharmacological treatment of migraine during pregnancy and breastfeeding

Headache in Challenging and Special Circumstances: Pregnancy and Lactation

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