Beta-blockers in the environment: Part II. Ecotoxicity study

Maszkowska, Joanna; Stolte, Stefan; Kumirska, Jolanta; Łukaszewicz, Paulina; Mioduszewska, Katarzyna; Puckowski, Alan; Caban, Magda; Wagil, Marta; Stepnowski, Piotr; Białk‐Bielińska, Anna

doi:10.1016/j.scitotenv.2014.06.039

Cited by 110 publications

(48 citation statements)

References 32 publications

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“…For example, Maszkowska et al (2014b) pointed out that the beta-blockers belong to the class of Endocrine Disruptive Compounds, since they can disrupt testosterone levels in male organisms. Therefore, it is important to assess the environmental risk posed by these contaminants.…”

Section: Introductionmentioning

confidence: 99%

Occurrence, ecotoxicological effects and risk assessment of antihypertensive pharmaceutical residues in the aquatic environment - A review

2015

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Section: Introductionmentioning

confidence: 99%

Occurrence, ecotoxicological effects and risk assessment of antihypertensive pharmaceutical residues in the aquatic environment - A review

2015

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“…As a result, the presence of b-blockers in the environment with concentrations in lg/L has been reported (Maszkowska et al 2014a). Although bblockers are safe for humans, some of the b-blockers are harmful to some aquatic organisms (Maszkowska et al 2014b).…”

Section: Introductionmentioning

confidence: 99%

Degradation of β-blockers in water by sulfate radical-based oxidation: kinetics, mechanism and ecotoxicity assessment

Tay

Ismail

2016

Int. J. Environ. Sci. Technol.

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This study investigated the kinetics and degradation pathway of acebutolol, metoprolol and sotalol in a sulfate radical-based advanced oxidation process. The selected pharmaceuticals were b-blockers which have been used to treat cardiovascular diseases. Due to its frequent use, the presence of these pharmaceuticals in the environment has been regularly reported. In this study, sulfate radicals were generated using peroxymonosulfate with cobalt (II) as activator. At pH 7 and 25°C, the secondorder rate constant for the reaction between SO 4 Á-with metoprolol, acebutolol and sotalol was (1.0 ± 0.1) 9 10 10 , (2.0 ± 0.1) 9 10 10 and (3.0 ± 0.2) 9 10 10 M -1 s -1 , respectively. Sixteen transformation by-products were identified from the selected b-blockers. These transformation by-products were mainly formed through the hydroxylation, aromatic ring-opening reaction and aliphatic chain oxidation. The decomposition of b-blockers by sulfate radicals was found to start from the formation of hydroxylated b-blockers followed by an aromatic ring-opening reaction. In general, this study showed that b-blockers reacted favorably with sulfate radicals, and various transformation by-products could be produced. The result from the ecotoxicity assessment showed that almost all of the transformation by-products were less toxic than its parent compound. Therefore, a sulfate radical-based advanced oxidation process could be an effective method for the treatment of b-blockers in water.

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“…As such, significantly higher concentrations of metoprolol (MT), one of the commonly prescribed b-blockers, were found in the leaves of plants grown in soils containing a low level of soil organic matter and clay (i.e., sandy and aeolian soils) since MT was most likely loosely bound to the negatively charged clay minerals and organic matter [13]. Toxicological data from a green algae test (Scenedesmus vacuolatus) suggested that propranolol and MT could be considered harmful to aquatic organisms, however, their sorption on solids may explicitly inhibit the hazardous effects [29].…”

Section: Introductionmentioning

confidence: 99%