Beta/Gamma EEG Activity in Patients with Primary and Secondary Insomnia and Good Sleeper Controls

Perlis, Michael L.; Smith, Michael T.; Andrews, Patrick J.; Orff, Henry J.; Giles, Donna E.

doi:10.1093/sleep/24.1.110

Cited by 414 publications

(302 citation statements)

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“…On electroencephalography (EEG), insomniacs demonstrate increased beta activity and lower delta activity (Krystal et al, 2002;Perlis et al, 2001). From an endocrine perspective, insomniacs, like patients with major depressive disorder, demonstrate corticotropin releasing factor hyperactivity, thus suggesting a role for hypothalamic-pituitary-adrenal axis dysfunction .…”

Section: Insomnia Pathogenesismentioning

confidence: 99%

Insomnia: Prevalence, Impact, Pathogenesis, Differential Diagnosis, and Evaluation

Mai

Buysse

2008

Sleep Medicine Clinics

250

153

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Section: Insomnia Pathogenesismentioning

confidence: 99%

Insomnia: Prevalence, Impact, Pathogenesis, Differential Diagnosis, and Evaluation

Mai

Buysse

2008

Sleep Medicine Clinics

250

153

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“…It is possible that the need for acute antidepressant drug treatment and sleep problems that persist following remission are clinical markers of a biologically distinct depressive subtype that is characterized by hyperarousal and a recurrent or chronic course. Hyperarousal is a state of abnormally high alertness in the sleep environment characterized by the failure to appropriately modulate the metabolic activity of the prefrontal cortex (Nofzinger et al 2004) and the brain's electrical activity during sleep (Krystal et al 2002;Merica et al 1998;Perlis et al 2001), by the sympathetic cardiovascular response (Bonnet and Arand 1997), hypercortisolemia (Rodenbeck et al 2002;Vgontzas et al 2001), and increased systemic metabolism (Bonnet and Arand 1995). Hyperarousal and, more broadly, disruption of the circadian cycle, appears to play a particularly important role in depressed women (Armitage 2007); it may interfere with mood regulation and thus precipitate new depressive episodes in these patients.…”

Section: Effects Of Persistent Insomnia On Moodmentioning

confidence: 99%

Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy?

Dombrovski¹,

Cyranowski²,

Mulsant³

et al. 2008

Depress. Anxiety

104

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Background-Even low levels of residual symptoms are known to increase the risk of relapse and early recurrence of major depression. It is not known if ongoing psychotherapy lessens this risk. We therefore examined the impact of persistent symptoms, including mood, insomnia, and anxiety symptoms, on time to recurrence in women receiving maintenance interpersonal psychotherapy (IPT-M) for recurrent depression.

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“…However, there is an increasing body of literature regarding the psychological and physiological differences between insomniacs and good sleepers. Several studies have demonstrated a greater prevalence of intrusive thoughts, worry, and rumination [8], poor sleep hygiene [9,10], dysregulation of the hypothalamic pituitary axis [11], elevations in sympathetic activity [12], and metabolic rate [13], increased daytime alertness [14], and elevated high-frequency electroencephalographic (EEG) activity [15][16][17] in patients with insomnia compared to good sleepers.…”

Section: Introductionmentioning

confidence: 99%

Stress-related sleep disturbance and polysomnographic response to caffeine

et al. 2006

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Background and purpose-To determine the sleep response to caffeine in individuals vulnerable to stress-related sleep disturbance as measured by polysomnography.Patients and methods-Eleven healthy individuals without insomnia scoring low (4 women, mean age=32.64 ± 15.46 years) and 10 healthy individuals also without insomnia scoring high (6 women, mean age=34.20 ± 13.73 years) on a measure of vulnerability to stress-related sleep disturbance were studied in a laboratory protocol. A moderate-low dose of caffeine (3 mg/kg) was administered 1 h prior to lights-out and compared to a counterbalanced control night with each condition separated by 1 week. Standard polysomnographic measures were assessed (i.e. total sleep time, sleep efficiency, latency to persistent sleep, and sleep stage percentages) for both control and caffeine nights.Results-There were no between-group differences in sleep on the control night. Importantly, individuals reporting vulnerability to stress-related sleep disturbance had significantly prolonged latency to persistent sleep in response to the caffeine challenge (interaction; P <0.05).Conclusion-Normal sleepers with an identified vulnerability to stress-induced sleep disturbance exhibited greater objectively verifiable sleep-reactivity in response to a caffeine challenge compared to non-vulnerable individuals. These results suggest that the construct of individual differences in vulnerability to sleep disturbance applies to a pharmacological 'stressor' (i.e. caffeine) as well as to previously assessed stressors such as a first-night effect. This finding provides further support for generalized trait vulnerability by demonstrating a sleep disturbance to a wake-promoting pharmacological challenge in specific a priori identified individuals.

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Beta/Gamma EEG Activity in Patients with Primary and Secondary Insomnia and Good Sleeper Controls

Cited by 414 publications

References 0 publications

Insomnia: Prevalence, Impact, Pathogenesis, Differential Diagnosis, and Evaluation

Insomnia: Prevalence, Impact, Pathogenesis, Differential Diagnosis, and Evaluation

Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy?

Stress-related sleep disturbance and polysomnographic response to caffeine

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