Beta-human chorionic gonadotrophin point of care testing for the management of pregnancy of unknown location

Kyriacou, Christopher; Kapur, Shikha; Jeyapala, Sobanakumari; Parker, Nina; Yang, Wei; Pikovsky, Margaret; Bobdiwala, Shabnam; Barcroft, Jennifer; Maheetharan, Shanuja; Sur, Shyamaly; Stalder, Catriona; Gould, Deborah; Syed, Shabana; Tan, Tricia; Bourne, Tom

doi:10.1016/j.rbmo.2023.103643

Reproductive BioMedicine Online

2024

DOI: 10.1016/j.rbmo.2023.103643

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Beta-human chorionic gonadotrophin point of care testing for the management of pregnancy of unknown location

Christopher Kyriacou,

Shikha Kapur,

Sobanakumari Jeyapala

et al.

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Conventional and modern markers of pregnancy of unknown location: Update and narrative review

Hou,

Liang,

Zeng

et al. 2024

Intl J Gynecology & Obste

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Pregnancy of unknown location (PUL) is a temporary pathologic or physiologic phenomenon of early pregnancy that requires follow up to determine the final pregnancy outcome. Evidence indicated that PUL patients suffer a remarkably higher rate of adverse pregnancy outcomes, represented by ectopic gestation and early pregnancy loss, than the general population. In the past few decades, discussion about PUL has never stopped, and a variety of markers have been widely investigated for the early and accurate evaluation of PUL, including serum biomarkers, ultrasound imaging features, multivariate analysis, and the diagnosis of ectopic pregnancy based on risk stratification. So far, machine learning (ML) methods represented by M4 and M6 logistic regression have gained a level of recognition and are continually improving. Nevertheless, the heterogeneity of PUL markers, mainly caused by the limited sample size, the differences in population and technical maturity, etc., have hampered the management of PUL. With the advancement of multidisciplinary integration and cutting‐edge technologies (e.g. artificial intelligence, prediction model development, and telemedicine), novel markers, and strategies for the management of PUL are expected to be developed. In this review, we summarize both conventional and novel markers (represented by artificial intelligence) for PUL assessment and management, investigate their advancements, limitations and challenges, and propose insights on future research direction and clinical application.

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Conventional and modern markers of pregnancy of unknown location: Update and narrative review

Hou,

Liang,

Zeng

et al. 2024

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

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Beta-human chorionic gonadotrophin point of care testing for the management of pregnancy of unknown location

Cited by 1 publication

References 27 publications

Conventional and modern markers of pregnancy of unknown location: Update and narrative review

Conventional and modern markers of pregnancy of unknown location: Update and narrative review

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