Beta-lactamase producingHaemophilus influenzae as causative agent of a liver abscess

Cantón, Rafael; León, Alfredo Ponce de; Fuente, Sonia de la; Carda, Pedro; Morales, Vicente; Baquero, Fernando; Messeguer, M. A.

doi:10.1007/bf01963768

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…The two reported cases of hepatic abscess in the literature were due to encapsulated strains of H. influenzae type b (Bradley et al, 1987;Cantó n et al, 1989), and our report is, to the best of our knowledge, the first report of a non-capsulated strain causing this presentation. The majority of cases of other hepatobiliary infections reported were similarly caused by encapsulated strains (Gó mez-Garcés et al, 1992;Oksuz et al, 2005).…”

Section: Discussionmentioning

confidence: 51%

“…It is part of the normal upper respiratory tract flora and can cause meningitis, otitis media, pneumonia, endocarditis, bacteraemia, osteomyelitis and septic arthritis (Oksuz et al, 2005). H. influenzae has also rarely been associated with hepatobiliary infections (Bradley et al, 1987;Cantó n et al, 1989;Oksuz et al, 2005). …”

Section: Discussionmentioning

confidence: 99%

“…There are two cases of hepatic abscess in the literature (from 1987 and 1989), reported in an 83-year-old female patient with a history of hydatid disease and in a 70-yearold male patient with recent nasal surgery (Bradley et al, 1987;Cantó n et al, 1989). Both patients had a history of cholecystectomy and, in both cases, the causative organism was found to be H. influenzae type b.…”

Section: Discussionmentioning

confidence: 99%

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Hepatobiliary infections due to non-capsulated Haemophilus influenzae

Talbot¹,

Alexander²,

Lewis³

et al. 2011

Journal of Medical Microbiology

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We present two cases of non-capsulated Haemophilus influenzae hepatobiliary infection and review the literature. Such cases are rare, and prior to routine immunization against H. influenzae serotype b invasive Haemophilus disease was largely caused by capsulated strains. The epidemiology of invasive Haemophilus infections has changed and the number of cases of intra-abdominal and hepatobiliary infection may be underestimated due to current microbiological processing practices. Case reports Case 1A 52-year-old male patient was admitted following a 6 week history of gradually worsening right upper quadrant pain. In the preceding 24 h he had experienced fever and rigors, but with no other symptoms. Four years previously he had developed gall stone-induced pancreatitis that necessitated a cholecystectomy. Since then he was an insulin-dependent diabetic. His other past medical history included hypothyroidism that was well controlled with levothryoxine. On examination he had a temperature of 39.5 u C and was tachycardic with a pulse rate of 120 beats min 21 . He was hypoxic on room air with a pO 2 (partial pressure of O 2 in arterial blood) of 7.4 kPa and had respiratory alkalosis. There was no jaundice or abdominal tenderness. Blood tests revealed a raised white cell count of 19.2610 9 cells l 21 (neutrophilia) and a C-reactive protein level of 185 mg l 21 . Liver function tests showed an elevated alkaline phosphatase level of 247 IU l 21 with normal bilirubin (8 mmol l 21 ) and alanine transaminase (8 IU l 21 ). His international normalized ratio was elevated at 1.5, and he had an albumin level of 34 mg l 21 . Blood cultures taken on admission were sterile after 5 days incubation. An abdominal ultrasound scan identified a large cystic lesion (12 by 15 cm) also visualized by computed tomography (CT) scanning in segments 5, 6, 7 and 8 of the liver with appearances consistent with an abscess (Fig. 1). A CT pulmonary angiogram was normal (performed in view of the hypoxia). A percutaneous drain was inserted under ultrasound guidance that revealed pus that on culture gave a pure growth of Haemophilus influenzae. Empirical treatment had already been started with intravenous coamoxiclav (1.2 g three times daily) and this was continued for 14 days before the patient was discharged with a further 14 days of oral co-amoxiclav (625 mg three times daily). The patient's inflammatory markers normalized and a repeat liver CT scan 6 weeks later showed resolution of the abscess. Magnetic resonance cholangiopancreatography revealed no apparent biliary aetiology for the liver abscess. Case 2A 32-year-old female patient presented with a 6 day history of severe, colicky epigastric and left-sided upper quadrant pain that was exacerbated by movement and lying on her left side. This was associated with vomiting, fever and rigors. She had experienced similar but less severe bouts of pain over the preceding 2 years. Her past medical history included polycystic ovarian syndrome and a hiatus hernia, and her only regular medication was a proton ...

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatobiliary infections due to non-capsulated Haemophilus influenzae

Talbot¹,

Alexander²,

Lewis³

et al. 2011

Journal of Medical Microbiology

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A case of biliary tract infection caused byHaemophilus parainfluenzae

Cattier

Caillon

Quentin

1992

Eur. J. Clin. Microbiol. Infect. Dis.

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Hepatobiliary Infections Caused by Haemophilus Species

O’Bryan

Whitener

Katzman

et al. 1992

Clinical Infectious Diseases

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Haemophilus species are rarely associated with hepatobiliary infections. We report a case of hepatic abscess caused by Haemophilus paraphrophilus and review the English-language literature for reports of infections of the liver and biliary system caused by Haemophilus species. Most patients identified had predisposing conditions. The pathogenesis of hepatobiliary infections due to Haemophilus species may involve ascending spread from the gastrointestinal tract or hematogenous seeding following oropharyngeal colonization.

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Beta-lactamase producingHaemophilus influenzae as causative agent of a liver abscess

Cited by 3 publications

References 8 publications

Hepatobiliary infections due to non-capsulated Haemophilus influenzae

Hepatobiliary infections due to non-capsulated Haemophilus influenzae

A case of biliary tract infection caused byHaemophilus parainfluenzae

Hepatobiliary Infections Caused by Haemophilus Species

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