Beta oscillations in freely moving Parkinson's subjects are attenuated during deep brain stimulation

Quinn, Emma J.; Blumenfeld, Zack; Velisar, Anca; Koop, Mandy Miller; Shreve, Lauren; Trager, Megan H.; Hill, Bruce C.; Kilbane, Camilla; Henderson, Jaimie M.; Brontë‐Stewart, Helen

doi:10.1002/mds.26376

Cited by 221 publications

(222 citation statements)

References 17 publications

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“…(ii) Currently, studies are performed to understand fundamental, attenuating effects of high-frequency deep brain stimulation on beta band LFP oscillations [59,60]. Nevertheless, the effects of DBS on oscillations of higher frequencies may be significant as well.…”

Section: Discussionmentioning

confidence: 99%

Suppression of spontaneous oscillations in high-frequency stimulated neuron models

Pyragas¹,

Tass²

2017

Lith. J. Phys.

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We analyze the influence of high-frequency current stimulation on spontaneous neuronal activity and show that it may cause a death of spontaneous low-frequency oscillations. We demonstrate the universality of this effect for typical neuron models such as FitzHugh-Nagumo, Morris-Lecar, and Hodgkin-Huxley neurons as well as for the normal form of the supercritical Hopf bifurcation. Using a multiple scale method we separate the solutions of the neuron equations into slow and fast components and derive averaged equations for the slow components. The mechanism of suppression of neuronal activity is explained by an analysis of the bifurcations in the averaged equations governing the dynamics of the slow motion. Our results may contribute to the understanding of therapeutic effects of high-frequency deep brain stimulation, the golden standard for the treatment of medically refractory patients suffering from Parkinson's disease. Furthermore, our study enables hypotheses concerning possible improvements of high-frequency deep brain stimulation.

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Section: Discussionmentioning

confidence: 99%

Suppression of spontaneous oscillations in high-frequency stimulated neuron models

Pyragas¹,

Tass²

2017

Lith. J. Phys.

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“…Note that our protocol stipulated that recordings on DBS would utilize each patient’s clinical settings, and that therapeutic settings would be determined based on clinical criteria without consideration for optimal research recording settings. Thus, in many cases, our DBS settings were not optimal for recordings during stimulation, particularly in STN where stimulation has a bigger impact on the occurrence of stimulation artifact 27 .…”

Section: Methodsmentioning

confidence: 99%

“…For STN recordings we also omitted files contaminated by electrocardiogram (EKG) artifact (see Results, missing STN data in Figure 3B and 4, and Quinn et al 2015.) This artifact was avoidable by excluding contact zero from the recording configuration 27 .…”

Section: Methodsmentioning

confidence: 99%

“…This device, Activa PC+S ( Medtronic, Inc ), allows chronic, intermittent collection of field potential data over years, initiated either by investigators in the clinic, by patients in their homes, or by automated algorithms 1,2,30,32,33 . The device is available to research groups worldwide under investigator-initiated protocols, or under CE Mark in European countries 15,20,27 . In our study, the stimulation/sensing pulse generator is attached to both a basal ganglia and a cortical electrode array, to allow multisite recordings for network-level analyses.…”

Section: Introductionmentioning

confidence: 99%

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Chronic multisite brain recordings from a totally implantable bidirectional neural interface: experience in 5 patients with Parkinson's disease

Swann¹,

Hemptinne²,

Miocinovic

et al. 2018

Journal of Neurosurgery

121

123

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OBJECTIVE Dysfunction of distributed neural networks underlies many brain disorders. Development of neuromodulation therapies depends on a better understanding of these networks. Invasive human brain recordings have a favorable temporal and spatial resolution for the analysis of network phenomena, but have generally been limited to acute intraoperative recording or short term recording through temporarily externalized leads. Here we describe our initial experience with an investigational, totally implantable, first generation, bidirectional neural interface that allows for both continuous therapeutic stimulation and recordings of field potentials at multiple sites in a neural network. METHODS We implanted five Parkinson’s disease patients with Activa PC+S (Medtronic Inc.), under a physician-sponsored Food and Drug Administration investigational device exemption. The device was attached to a quadripolar lead placed in the subdural space over motor cortex, for recording of electrocorticography (ECoG) potentials, and to a quadripolar lead in subthalamic nucleus (STN) for both therapeutic stimulation and recording of local field potentials (LFPs). We recorded from each patient at multiple time points over a one year period. RESULTS There were no serious surgical complications or interruptions of DBS therapy. Signals in both cortex and STN were relatively stable over time, despite a gradual increase in electrode impedance. We were able to identify canonical movement related changes in specific frequency bands in motor cortex in most but not all recordings. CONCLUSION Acquisition of chronic multisite field potentials in humans is feasible. Device performance characteristics described here may inform the design of the next generation of totally implantable neural interfaces. This research tool provides a platform for translation of discoveries in brain network dynamics to improved neurostimulation paradigms.

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“…However, invasive measurements such as ECoG and LFP recordings from intra-operative procedures and externalized leads are accompanied by considerable ethical issues. Newer technology with the ability to wirelessly transfer data outside from the implanted pulse generator may improve the access to recordings from deeper structures (Quinn et al, 2015), which may thus 5.4 Perspectives enable recording from deeper brain structures without externalization of leads. Wireless transmission of deep brain data along with mobile EEG setups can enable experiments where PD patients are mobile, compared to the relatively immobile setup in our studies with patients lying in supine position.…”

Section: Perspectivesmentioning

confidence: 99%

Neuromagnetic investigations of mechanisms and effects of STN-DBS and medication in Parkinson's disease

Sridharan¹

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Beta oscillations in freely moving Parkinson's subjects are attenuated during deep brain stimulation

Abstract: Beta power was conserved during resting and forward walking states and was attenuated in a voltage-dependent manner during 140-Hz DBS. Phenotype may be an important consideration if this is used for closed-loop DBS.

Cited by 221 publications

References 17 publications

Suppression of spontaneous oscillations in high-frequency stimulated neuron models

Suppression of spontaneous oscillations in high-frequency stimulated neuron models

Chronic multisite brain recordings from a totally implantable bidirectional neural interface: experience in 5 patients with Parkinson's disease

Neuromagnetic investigations of mechanisms and effects of STN-DBS and medication in Parkinson's disease

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