Beta oscillations in the parkinsonian primate: Similar oscillations across different populations

Matzner, Ayala; Moran, Anan; Erez, Yaara; Tischler, Hadass; Bar‐Gad, Izhar

doi:10.1016/j.nbd.2016.04.003

Cited by 5 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The power of beta-band (~ 20 to 40 Hz) oscillations is enhanced in the LFP in MC and STN, and even in the other major sites in the cortico-subcortical re-entrant loops in PD [94,[97][98][99][100]. Beta augmentation has long been considered also as a critical element responsible for the locomotor deficits of PD.…”

Section: Possible Pathophysiological Implications Of Beta Synchroniza...mentioning

confidence: 99%

An electrophysiological perspective on Parkinson’s disease: symptomatic pathogenesis and therapeutic approaches

et al. 2021

View full text Add to dashboard Cite

Parkinson’s disease (PD), or paralysis agitans, is a common neurodegenerative disease characterized by dopaminergic deprivation in the basal ganglia because of neuronal loss in the substantia nigra pars compacta. Clinically, PD apparently involves both hypokinetic (e.g. akinetic rigidity) and hyperkinetic (e.g. tremor/propulsion) symptoms. The symptomatic pathogenesis, however, has remained elusive. The recent success of deep brain stimulation (DBS) therapy applied to the subthalamic nucleus (STN) or the globus pallidus pars internus indicates that there are essential electrophysiological abnormalities in PD. Consistently, dopamine-deprived STN shows excessive burst discharges. This proves to be a central pathophysiological element causally linked to the locomotor deficits in PD, as maneuvers (such as DBS of different polarities) decreasing and increasing STN burst discharges would decrease and increase the locomotor deficits, respectively. STN bursts are not so autonomous but show a “relay” feature, requiring glutamatergic synaptic inputs from the motor cortex (MC) to develop. In PD, there is an increase in overall MC activities and the corticosubthalamic input is enhanced and contributory to excessive burst discharges in STN. The increase in MC activities may be relevant to the enhanced beta power in local field potentials (LFP) as well as the deranged motor programming at the cortical level in PD. Moreover, MC could not only drive erroneous STN bursts, but also be driven by STN discharges at specific LFP frequencies (~ 4 to 6 Hz) to produce coherent tremulous muscle contractions. In essence, PD may be viewed as a disorder with deranged rhythms in the cortico-subcortical re-entrant loops, manifestly including STN, the major component of the oscillating core, and MC, the origin of the final common descending motor pathways. The configurations of the deranged rhythms may play a determinant role in the symptomatic pathogenesis of PD, and provide insight into the mechanism underlying normal motor control. Therapeutic brain stimulation for PD and relevant disorders should be adaptively exercised with in-depth pathophysiological considerations for each individual patient, and aim at a final normalization of cortical discharge patterns for the best ameliorating effect on the locomotor and even non-motor symptoms.

show abstract

Section: Possible Pathophysiological Implications Of Beta Synchroniza...mentioning

confidence: 99%

An electrophysiological perspective on Parkinson’s disease: symptomatic pathogenesis and therapeutic approaches

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Subthalamic nucleus 4 (STN) local field potential 5 (LFP) recordings demonstrate oscillatory neuronal activity in both the alpha (8–12 Hz) and beta (13–30 Hz) bands in the resting state in PD ( Brown P J Neurosci 2001, Bronte-Stewart et al, 2009; Hammond, Bergman, & Brown, 2007; Kühn, Kupsch, Schneider, & Brown, 2006; Matzner, Moran, Erez, Tischler, & Bar-Gad, 2016; Ray et al, 2008; Shreve et al, 2017; Whitmer et al, 2012; Wingeier et al, 2006). Both alpha and beta band oscillations have been linked to a sensorimotor rhythm (Bevan, Magill, Terman, Bolam, & Wilson, 2002; Chen, Wu, Sheu, Chow, & Lin, 2007; Kühn et al, 2005) in the basal ganglia, and the cortical alpha rhythm has also been associated with executive function and attentional tasks (Horn, Neumann, Degen, Schneider, & Kühn, 2017; Jahanshahi, 2013).…”

Section: Introductionmentioning

confidence: 99%

Subthalamic neural entropy is a feature of freezing of gait in freely moving people with Parkinson's disease

Syrkin-Nikolau

Koop

Prieto

et al. 2017

Neurobiology of Disease

View full text Add to dashboard Cite

A novel turning and barrier course was superior to FW in eliciting FOG. Greater unpredictability in subthalamic beta rhythms was evident during stepping without freezing episodes in Freezers compared to Non-Freezers, whereas greater unpredictability in alpha rhythms was evident in Freezers during FOG. Non-linear analysis of dynamic neural signals during gait in freely moving people with PD may yield greater insight into the pathophysiology of FOG; whether the increases in STN entropy are causative or compensatory remains to be determined. Some beta LFP power may be useful for rhythmic, symmetric gait and DBS parameters, which completely attenuate STN beta power may worsen rather than improve FOG.

show abstract

“…Neuronal oscillations are broadly distributed throughout the brain; nonetheless, the role they play in health and disease and how their characteristics evolve with disease progression remain elusive ( Sharott et al, 2005 ; Leventhal et al, 2012 ; Basar, 2013 ; Basar and Guntekin, 2013 ; Matzner et al, 2016 ; Giovanni et al, 2017 ; Kuo et al, 2019 ; Mizrahi-Kliger et al, 2020 ). The movement production network provides an excellent model for studying oscillations in health and disease because brain oscillations play a prominent role in the performance of smooth and accurate movements in healthy individuals (for physiological tremor see Schnitzler et al, 2006 ; Williams et al, 2010 ), and network malfunction disrupts overt movements ( Hutchison et al, 2004 ; Schnitzler et al, 2006 ; Mallet et al, 2008 ; Crowell et al, 2012 ; Kondylis et al, 2016 ; Bhatia et al, 2018 ; Schnitzler et al, 2018 ; Dubbioso and Tomasevic, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Chemical suppression of harmaline-induced body tremor yields recovery of pairwise neuronal coherence in cerebellar nuclei neurons

Baumel

Yamin

Cohen

2023

Front. Syst. Neurosci.

View full text Add to dashboard Cite

Neuronal oscillations occur in health and disease; however, their characteristics can differ across conditions. During voluntary movement in freely moving rats, cerebellar nuclei (CN) neurons display intermittent but coherent oscillations in the theta frequency band (4–12 Hz). However, in the rat harmaline model of essential tremor, a disorder attributed to cerebellar malfunction, CN neurons display aberrant oscillations concomitantly with the emergence of body tremor. To identify the oscillation features that may underlie the emergence of body tremor, we analyzed neuronal activity recorded chronically from the rat CN under three conditions: in freely behaving animals, in harmaline-treated animals, and during chemical suppression of the harmaline-induced body tremor. Suppression of body tremor did not restore single neuron firing characteristics such as firing rate, the global and local coefficients of variation, the likelihood of a neuron to fire in bursts or their tendency to oscillate at a variety of dominant frequencies. Similarly, the fraction of simultaneously recorded neuronal pairs oscillating at a similar dominant frequency (<1 Hz deviation) and the mean frequency deviation within pairs remained similar to the harmaline condition. Moreover, the likelihood that pairs of CN neurons would co-oscillate was not only significantly lower than that measured in freely moving animals, but was significantly worse than chance. By contrast, the chemical suppression of body tremor fully restored pairwise neuronal coherence; that is, unlike in the harmaline condition, pairs of neurons that oscillated at the same time and frequency displayed high coherence, as in the controls. We suggest that oscillation coherence in CN neurons is essential for the execution of smooth movement and its loss likely underlies the emergence of body tremor.

show abstract

Beta oscillations in the parkinsonian primate: Similar oscillations across different populations

Cited by 5 publications

References 37 publications

An electrophysiological perspective on Parkinson’s disease: symptomatic pathogenesis and therapeutic approaches

An electrophysiological perspective on Parkinson’s disease: symptomatic pathogenesis and therapeutic approaches

Subthalamic neural entropy is a feature of freezing of gait in freely moving people with Parkinson's disease

Chemical suppression of harmaline-induced body tremor yields recovery of pairwise neuronal coherence in cerebellar nuclei neurons

Contact Info

Product

Resources

About