Beta‐thromboglobulin in Pre‐eclampsia

Leiberman, J. R.; Aharon, M.; Schuster, Meike; Plotnick-schtadler, T.; Nathan, Ilana; Dvilansky, A

doi:10.3109/00016348509155157

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…β-TG level was also comparable between 2nd trimester, 3rd trimester pregnant women and non-pregnant women. This finding is in accordance with previous observations by Leiberman et al (1985) and Romero et al (1988). They have also reported that gestational age, labor, and puerperium did not affect plasma β-TG concentrations.…”

Section: Discussionsupporting

confidence: 93%

Hyperprolactinemia of Pregnancy is Not Associated with Increased In Vivo Platelet Activity and Shortened In Vitro Bleeding Times

Atmaca

Gürlek²,

Dağdelen³

et al. 2006

Exp Clin Endocrinol Diabetes

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The aim of the study is to investigate whether platelet activity is increased by hyperprolactinemia during pregnancy as reflected by beta-thromboglobulin level. Forty-eight healthy, pregnant, and 30 healthy, non-pregnant women were investigated with respect to platelet count, collagen/ADP and collagen/epinephrine closure times, beta-thromboglobulin and prolactin levels. The comparison of the variables between the two groups was made by Mann-Whitney U test. The correlation analyses were performed by Spearman's rank correlation test. Our results revealed that platelet counts, collagen/ADP and collagen/epinephrine closure times and beta-thromboglobulin showed no statistically significant differences between pregnant and non-pregnant women. We found no significant correlation between prolactin and collagen/ADP closure time (r = 0.175), between prolactin and collagen/epinephrine closure time (r = -0.112) and between prolactin and beta-thromboglobulin (r = 0.220) in pregnant women. Our findings suggest that platelet activity is comparable during pregnant and non-pregnant states and there is no significant effect of prolactin on platelet function in vivo as reflected by beta-thromboglobulin level.

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Section: Discussionsupporting

confidence: 93%

Hyperprolactinemia of Pregnancy is Not Associated with Increased In Vivo Platelet Activity and Shortened In Vitro Bleeding Times

Atmaca

Gürlek²,

Dağdelen³

et al. 2006

Exp Clin Endocrinol Diabetes

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“…On the other hand, we found that in severe preeclampsia the bleeding time was markedly prolonged, not associated to the slight reduction of the platelet count observed in this group of patients. Previous studies in preeclamptic patients havc shown an early platelet activation, which is evidenced by the release of B-thromboglobulin and platelet factor 4 (1, 10, 11, 13,13,14), and by the decrease of the endogenous serotonin in the platelet (1 5); moreover, thromboxane released by t h e platelets enhances platelet aggregation and maintains the imbalance with prostacyclin, which is a ugmented in preeclampsia (16,17). These functional modifications, both in platelets and in endothelial cells, suggested by different markers of the endothelial cell injury reported in preeclatnpsia ( 18, 19,20,21,22), may have a role in the bleeding time modifications in preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Bleeding time in preeclampsia

Ivankovic¹,

Pereira

Bianchi³

et al. 1994

Acta Obstet Gynecol Scand

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The association of preeclampsia with thrombocytopenia and prolonged bleeding time is reported. The analysis of bleeding time (Simplate II) and the platelet count (Automatic Coulter Counter) in 41 patients with different grades of preeclampsia is presented. Our results suggest that the decrease in the bleeding time observed in moderate preeclampsia and the increase observed in severe preeclampsia are not mainly dependent on the platelet count.

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Plasma and urine beta-thromboglobulin in severe preeclampsia

Leiberman

Hagay

Mazor

et al. 1988

Arch Gynecol Obstet

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Beta-thromboglobulin (BTG) has been shown to be a specific platelet protein and can be used as a marker of platelet activation in preeclampsia. Concomitant studies of BTG levels in plasma and urine were performed with eight primiparous severe preeclamptic patients and eight normal primiparous women matched for age. The mean plasma BTG in the severe preeclamptic patients was 186.62 +/- 29.93 ng/ml, and in the control group 45.38 +/- 31.84 ng/ml. The P-value for the difference was highly significant (P = 0.000). In contrast, the mean urine BTG in the study group was 8.42 +/- 4.61 ng/ml, while the mean value for the control group was similar, 5.00 +/- 3.20 ng/ml. The P-value for the difference was not significant (0.05 less than P less than 0.10). These results show that urinary BTG cannot be considered an indicator of platelet activation in severe preeclampsia. A low urinary BTG concentration in the presence of high plasma BTG levels may rather express renal impairment. Failure of BTG renal clearance would contribute to further raising the level of plasma BTG.

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Beta‐thromboglobulin in Pre‐eclampsia

Cited by 5 publications

References 19 publications

Hyperprolactinemia of Pregnancy is Not Associated with Increased In Vivo Platelet Activity and Shortened In Vitro Bleeding Times

Hyperprolactinemia of Pregnancy is Not Associated with Increased In Vivo Platelet Activity and Shortened In Vitro Bleeding Times

Bleeding time in preeclampsia

Plasma and urine beta-thromboglobulin in severe preeclampsia

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