Beta2-adrenoceptor agonists for dysmenorrhoea

Fedorowicz, Zbys; Nasser, Mona; Jagannath, Vanitha A; Beaman, Jessica; Ejaz, Kiran; Zuuren, Esther J van

doi:10.1002/14651858.cd008585.pub2

Cited by 10 publications

(5 citation statements)

References 30 publications

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“…Primary dysmenorrhea (PDM) is defined as the regular onset of painful, spasmodic cramping in the lower abdomen in women with normal pelvic anatomy. 10,14,15,18 Despite the negative impact of menstrual pain on multiple aspects of women's personal lives, most neuroimaging studies on PDM focus on the relationship between menstrual pain and brain abnormalities. Given that pain is not only a sensory experience but also an emotional event, 12,22,23 the effects of menstrual pain on the psychological and affective states of women, such as empathy, should also be considered.…”

Section: Introductionmentioning

confidence: 99%

The effects of long-term menstrual pain on pain empathy in women with primary dysmenorrhea

Wang

Dun

et al. 2021

Pain

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Primary dysmenorrhea (PDM) is not only a painful experience but also affects the psychological and affective states of women. Neuroimaging studies have revealed shared neural substrates for somatic and empathic pains in healthy subjects. However, little is known about the relationship between pain intensity and pain empathy in pain disorders. The cyclic nature of PDM makes it a unique model for investigating this issue during a patients' pain phase. To study how long-term pain modulates empathy for pain, T1-weighted magnetic resonance imaging scans were obtained in 39 PDM patients and 41 matched female healthy controls during menstruation. Subjects viewed static visual stimuli of the limbs submitted to painful and nonpainful stimulation to solicit empathy. The visual analogue scale for pain intensity and the Interpersonal Reactivity Index for empathic ability were also obtained. We found that women with PDM exhibited higher pain empathy compared with controls. The anterior insula and brain regions related to sensory discrimination with decreased gray matter volumes were not only shared but also acted as a mediator between pain intensity and pain empathy in PDM patients. In addition, the general linear modeling analysis revealed that long-term pain experience was a more important factor to pain empathy compared with pain intensity. This indicated that long-term pain may cause maladaptive brain structural plasticity, which may further affect psychological adjustment to bring patients more vivid pain when they witness suffering and distress in others.

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Section: Introductionmentioning

confidence: 99%

The effects of long-term menstrual pain on pain empathy in women with primary dysmenorrhea

Wang

Dun

et al. 2021

Pain

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“…Overall the evi dence supporting their use is very poor and they are associated with significant sideeffects, therefore their use is not recom mended. 12 …”

Section: Other Pharmacological Treatmentsmentioning

confidence: 99%

Treatment options for primary and secondary dysmenorrhoea

Mavrelos¹,

Sarıdoğan²

2017

Prescriber

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“…Eldeki veriler, dismenore tedavisinde Beta2-adrenoseptörün kullanımı hakkında güvenli karar vermeyi sağlamak için yeterli kanıt olmadığı göstermektedir (I-D). 43…”

Section: Tibbi̇ Tedavi̇unclassified