Betacellulin Regulates Peripheral Nerve Regeneration by Affecting Schwann Cell Migration and Axon Elongation

Wang, Yaxian; Zhang, Fuchao; Zhang, Yunsong; Shan, Qi; Liu, Wei; Zhang, Fengyuan; Zhang, Feiyu; Yi, Sheng

doi:10.21203/rs.3.rs-174606/v1

Cited by 1 publication

(1 citation statement)

References 28 publications

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“…At the early stage, SCs go through dedifferentiation, proliferation, myelin sheath clearance, this stage is characterized by proliferation of SCs 14,29 . Then at the later stage, repair SCs migrate into the lesion site, form bunger's band, which will create a permissive environment for nerve regeneration [30][31] . The change of SCs in two stages regulate by various cellular and molecular factors 14,[32][33][34] .…”

Section: Discussionmentioning

confidence: 99%

Bone Marrow Derived Cells Mediated Regulation of Schwann Cells Proliferation and Migration In Vitro

Wang

Zhao

Chen

et al. 2022

Preprint

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Schwann cells (SCs) are the unique glial cells in the peripheral nerve. After peripheral nerve injury, SCs change their morphology, function, and play a new role as repair cells, through this process, factors that enhance SCs proliferation and promote SCs migration will benefit nerve regeneration and functional recovery. Bone marrow-derived cells (BMDCs), which has been proved to offer several regenerative benefits for tissue and organ injuries. However, whether BMDCs support nerve regeneration by affect the proliferation and migration of SCs, remains unclear. Here, we taken BMDCs co-cultured with nerve segments, and then investigated the proliferation and migration of SCs in vitro. Results demonstrated that BMDCs can enhance the proliferation of SCs, and then promoted SCs migration, forming Bungner’s brand-liked structure in vitro. These finding provide a potential new method for repair of injured peripheral nerves in clinical.

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