2022
DOI: 10.3390/ani12121530
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Betaine Promotes Fat Accumulation and Reduces Injury in Landes Goose Hepatocytes by Regulating Multiple Lipid Metabolism Pathways

Abstract: Betaine is a well-established supplement used in livestock feeding. In our previous study, betaine was shown to result in the redistribution of body fat, a healthier steatosis phenotype, and an increased liver weight and triglyceride storage of the Landes goose liver, which is used for foie-gras production. However, these effects are not found in other species and strains, and the underlying mechanism is unclear. Here, we studied the underpinning molecular mechanisms by developing an in vitro fatty liver cell … Show more

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Cited by 5 publications
(4 citation statements)
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“…According to our findings, relative liver weights of quails fed with Bet enriched diets were statistically higher than the control and other treatment groups. One possible explanation for this situation is that lipid metabolism regulation activity of Bet might result in an increase in the number of hepatocytes and their size due to the accumulation of triglycerides in liver cells (Liu et al 2022).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…According to our findings, relative liver weights of quails fed with Bet enriched diets were statistically higher than the control and other treatment groups. One possible explanation for this situation is that lipid metabolism regulation activity of Bet might result in an increase in the number of hepatocytes and their size due to the accumulation of triglycerides in liver cells (Liu et al 2022).…”
Section: Discussionmentioning
confidence: 99%
“…Likewise, other studies also noted that the use of dietary Bet (Rama Rao et al 2011, Uzunoğlu and Yalçın 2019, El-Bahr et al 2021) and butyrate (Yin et al 2016, Deepa et al 2017, Elnesr et al 2019 in poultry nutrition leads to a decrease in blood lipid values, similar to our findings. Both Bet and PCB contribute to the fat accumulation to the metabolism in poultry (Liu et al 2022).…”
Section: Discussionmentioning
confidence: 99%
“…19 In addition to its strong antioxidant properties, betaine also has significant pharmacological effects. It may prevent hyperhomocysteinemia, 20 protect the liver, 21 have a positive effect on cardiometabolic health, 22 inhibit tumors, have anticancer effects, lower blood pressure, cause sedation, and relieve pain and fever. 23…”
Section: Introductionmentioning
confidence: 99%
“…19 In addition to its strong antioxidant properties, betaine also has significant pharmacological effects. It may prevent hyperhomocysteinemia, 20 protect the liver, 21 have a positive effect on cardiometabolic health, 22 inhibit tumors, have anticancer effects, lower blood pressure, cause sedation, and relieve pain and fever. 23 Betaine has been found to have a positive effect on fatty liver disease by methionine choline deficiency by regulating oxidative stress, inflammation, and cell death.…”
Section: Introductionmentioning
confidence: 99%