Betalain- and betacyanin-rich supplements’ impacts on the PBMC SIRT1 and LOX1 genes expression and Sirtuin-1 protein levels in coronary artery disease patients: A pilot crossover clinical trial

Rahimi, Parisa; Mesbah‐Namin, Seyed Alireza; Ostadrahimi, Alireza; Separham, Ahmad; Jafarabadi, Mohammad Asghari

doi:10.1016/j.jff.2019.06.003

Cited by 36 publications

(23 citation statements)

References 56 publications

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“…Further studies are required to determine betanin and indicaxanthin absorption in prickly pear varieties from the Canary Islands (Spain). This is of importance because betalains may affect age-related diseases because of their influence on human cell lifespan and aspects of age-dependent atherosclerosis [36,37]. Furthermore, no metabolites or degraded products could be detected by HPLC during the stages of the in vitro gastrointestinal digestion in the present study.…”

Section: Bioaccessibility In Pulps (Edible Fraction)mentioning

confidence: 57%

Digestive Stability and Bioaccessibility of Antioxidants in Prickly Pear Fruits from the Canary Islands: Healthy Foods and Ingredients

et al. 2020

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Although prickly pear fruits have become an important part of the Canary diet, their native varieties are yet to be characterized in terms of betalains and phenolic compounds. To exert potential health benefits, these antioxidants must be released from the food matrix and be stable in the gastrointestinal tract. Our aim was to characterize the betalain and phenolic profile of four prickly pear varieties from the Canary Islands (Spain) and determine their digestive stability and bioaccessibility via in vitro gastrointestinal digestion. Digestive studies were performed considering the (i) importance of the edible fraction (pulps) and (ii) potential of fruit peels as by-products to obtain healthy ingredients. Betalains and phenolic profiles were analyzed by HPLC-DAD-ESI/MS and HPLC-DAD-MS/QTOF. Pulps in Colorada and Fresa varieties presented high indicaxanthin and betanin content, respectively. Despite low pH in the gastric phase, betalains were stable to reach the intestinal phase, although indicaxanthin presented a higher bioaccessibility. Blanco Buenavista peels contained a distinct flavonoid profile including a new isorhamnetin-hexosyl-rhamnoside. Phenolic compounds were abundant and highly bioaccessible in fruit peels. These findings suggest that prickly pear pulps are rich in bioaccessible betalains; and that their peels could be proposed as potential by-products to obtain sustainable healthy ingredients.

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Section: Bioaccessibility In Pulps (Edible Fraction)mentioning

confidence: 57%

Digestive Stability and Bioaccessibility of Antioxidants in Prickly Pear Fruits from the Canary Islands: Healthy Foods and Ingredients

et al. 2020

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“…In AML mice, treatment with betanin decreased LDL levels [ 49 ]. The consumption of a non-lipid diet increased serum TC, TC/HDL-c ratio, triglyceride (TAG) and atherogenic index, but decreased short-chain fatty acid (SCFA) production in rats [ 50 ]. However, the use of red beetroot (RBR) crisps inhibited the growth of TC and TAG, resulting in a higher probability of elevated total SCFA pool.…”

Section: Therapeutic Effect Of Betalainsmentioning

confidence: 99%

“…After that, the apoptotic pathway is activated by caspase 3 and other genes involved in apoptosis, as shown in Figure 6 . In another study, treatment with betanin/isobetanin resulted in a significant reduction in the proliferation and survival of cancer cells, changes in mitochondrial membrane potential (via both internal and external apoptosis pathways) and the formation of autophagous vesicles in MCF-7-treated cells [ 50 ]. In addition to a significant increase in the protein expression of Bad , TRAILR4 , FAS and p53 , the treatment led to autophagic cell death.…”

Section: Therapeutic Effect Of Betalainsmentioning

confidence: 99%

Therapeutic Application of Betalains: A Review

Madadi

Mazloum-Ravasan

et al. 2020

Plants

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Anthocyanins, betalains, riboflavin, carotenoids, chlorophylls and caramel are the basic natural food colorants used in modern food manufacture. Betalains, which are composed of red–violet betacyanin and yellow betaxanthins, are water-soluble pigments that color flowers and fruits. Betalains are pigments primarily produced by plants of the order Caryophyllales. Because of their anti-inflammatory, cognitive impairment, anticancer and anti-hepatitis properties, betalains are useful as pharmaceutical agents and dietary supplements. Betalains also exhibit antimicrobial and antimalarial effects, and as an example, betalain-rich Amaranthus spinosus displays prominent antimalarial activity. Studies also confirmed the antidiabetic effect of betalains, which reduced glycemia by 40% without causing weight loss or liver impairment. These findings show that betalain colorants may be a promising alternative to the synthetic dyes currently used as food additives.

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“…Several studies have depicted the anti-inflammatory properties of betanins. These properties have been demonstrated in both the experimental and the clinical levels [56,66,67]. Rahimi and colleagues have illustrated that betalains administration has resulted in a prominent activation of Sirtuin-1 (SIRT1), with a concomitant decrease in Lectin-like Oxidized LDL Receptor 1 expression level, and plasma concentration of the inflammatory marker high sensitive C Reactive Protein (hs-CRP), in a group of patients experiencing coronary artery disease.…”

Section: Betanin and Inflammationmentioning

confidence: 99%

“…Hence, the authors concluded that betalains are capable of providing some protection against the development of cardiovascular diseases. However, the exact mechanism beyond these effects, and whether betanin plays a specific role in such findings, or alternatively, they are attributed to the nitrate content of beetroots, was not demonstrated [66]. In an attempt to dig further beyond these effects, Bhaswant and coworkers examined oral beetroot juice in comparison to sodium nitrate in rats fed a high-carbohydrate, high-fat diet, hence, exhibiting cardiometabolic, as well as, hepatic changes.…”

Section: Betanin and Inflammationmentioning

confidence: 99%

Betanin: a promising molecule for biomedical applications

2020

Biointerface Res Appl Chem

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Plants with medicinal properties possess beneficial influences on health and disease. Different plant parts and extracts carry valuable active ingredients with pharmacological properties that lead to developing new drugs. Terminalia bellirica is among those plants that have been formulated as pharmaceutical products. This is attributed to its biologically active phenolics and tannins exhibiting analgesic, anti-hypertensive, anti-microbial, anti-diabetic, anti-oxidant, as well as, other pharmacological properties. Beetroot has been shown to be rich in nitrates with a positive impact on the cardiovascular system. Beetroot contains a number of useful ingredients as the free-radical scavenger ascorbic acid, the anti-inflammatory flavonoids and the anti-oxidant carotenoids. Moreover, beetroot is rich in the natural colorant betalains that are further classified into betacyanins and betaxanthins. Betanin, is one of the major constituents of beetroots that have been postulated to possess significant beneficial therapeutic effects in a number of conditions and diseases. However, several studies have demonstrated the relatively poor bioavailability of betanin upon oral administration. In the current review we aim to highlight some of the latest researches dealing with the therapeutic properties of betanin in different disease conditions, the possible mechanistic pathways beyond such beneficial effects and plausible strategies capable of enhancing its stability and bioavailability.

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Betalain- and betacyanin-rich supplements’ impacts on the PBMC SIRT1 and LOX1 genes expression and Sirtuin-1 protein levels in coronary artery disease patients: A pilot crossover clinical trial

Cited by 36 publications

References 56 publications

Digestive Stability and Bioaccessibility of Antioxidants in Prickly Pear Fruits from the Canary Islands: Healthy Foods and Ingredients

Digestive Stability and Bioaccessibility of Antioxidants in Prickly Pear Fruits from the Canary Islands: Healthy Foods and Ingredients

Therapeutic Application of Betalains: A Review

Betanin: a promising molecule for biomedical applications

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