Betanidin significantly reduces blood glucose levels in BALB/c mice fed with an atherogenic diet

Lugo-Radillo, Agustín; Delgado‐Enciso, Iván; Peña-Beltran, Elpidio

doi:10.1007/s13659-012-0034-z

Cited by 23 publications

(24 citation statements)

References 15 publications

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“…The authors contemplated that these observed effects could counter metabolic dysfunctions, because the efficiency, even at very low concentration, was much higher than resveratrol, an approved therapeutic agent (Baur and Sinclair ). Partially supporting the claim of reducing blood glucose levels, betanidin, a red beetroot betalain, was shown to exhibit hypoglycemic effect in mice (Lugo‐Radillo and others ).…”

Section: Dietary Safetymentioning

confidence: 85%

“…Recent studies have reported betalains’ ability to counteract diabetic complications as effects of chronic hyperglycemia. A short report on the hypoglycemic effect of betanidin in mice was published by Lugo‐Radillo and others (). They observed a 50% reduction in the blood sugar levels of mice fed an atherogenic diet (24 wk) when supplemented with betanidin (9.6 mg) for the last 40 d. This study set off a few other investigations on hypoglycemic effect of betalain‐rich preparations or purified betalains.…”

Section: Dietary Safetymentioning

confidence: 99%

“…However, it was apparent that betalain‐rich meals significantly reduced glucose absorption. Lugo‐Radillo and others () used a high‐fat diet known to induce atherosclerotic plaques. Although the researchers observed good glycemic response, they did not explore the effect of betanidin feeding on atherosclerosis‐related pathophysiology which causes cardiac arrest.…”

Section: Dietary Safetymentioning

confidence: 99%

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Plant Betalains: Safety, Antioxidant Activity, Clinical Efficacy, and Bioavailability

Khan

2015

Comp Rev Food Sci Food Safe

208

127

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Betalains are accepted food additives derived from vacuoles of plants belonging to about 17 families in the order Caryophyllales. These pigments are composed of a nitrogenous core structure, betalamic acid [4-(2-oxoethylidene)-1,2,3,4-tetrahydropyridine-2,6-dicarboxylic acid]. Betalamic acid condenses with imino compounds (cyclo-DOPA and/or its glucosyl derivatives) or amines and/or their derivatives to form violet betacyanins (for example, betanin) and yellow betaxanthins (for example, indicaxanthin), respectively. Till date, structures of 75 betalains have been elucidated from plants under the order Caryophyllales. The extracted betalains are safe to consume and they act as micronutrients in the body. In vitro studies to highlight radical-scavenging activity, cell culture studies to assess cytotoxicity and absorption of betalains, and proven clinical efficacies are compiled in this review. The literature on biological activity has not been analyzed for a synthesis of safety, clinical efficacy, and bioavailability to arrive at the concentrations required for the purported health benefits. Most betalains are under-utilized in pharmaceutical and cosmetic preparations due to poor stability and lack of scientific reports highlighting their superior tinctorial strength including flourescence, water solubility, and functional value alongside their bioavailability. This is the first comprehensive review on the dietary safety, biological activity and bioavailability of betalains. Based on this review, for future debate and input from health professionals, a human daily intake of betanin and indicaxanthin can be proposed at 100 and 50 mg, respectively.

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Section: Dietary Safetymentioning

confidence: 85%

Section: Dietary Safetymentioning

confidence: 99%

Section: Dietary Safetymentioning

confidence: 99%

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Plant Betalains: Safety, Antioxidant Activity, Clinical Efficacy, and Bioavailability

Khan

2015

Comp Rev Food Sci Food Safe

208

127

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“…In contrast to anthocyanins, betalains have carboxyl functional groups instead of hydroxyl functional groups (Al‐Alwani, Mohamad, Kadhum, & Ludin, ). Betanins possessed a wide range of biological activities as antioxidant, anti‐inflammatory, hypoglycemic, antiproliferative, cardioactive, radioprotective, neuroprotective, diuretic, hypolipidemic, and osteoarthritis pain reliever (Esatbeyoglu et al, ; Khan, ; Lugo‐Radillo, Delgado‐Enciso, & Pena‐Beltrăn, ). The details of their biological activities had been discussed in previous reviews (Gandía‐Herrero, Escribano, & Garcìa‐Carmona, ; Khan, ).…”

Section: Chemical Constituentsmentioning

confidence: 99%

GenusHylocereus: Beneficial phytochemicals, nutritional importance, and biological relevance-A review

et al. 2018

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The genus Hylocereus (family Cactaceae) includes about 16 species. Now its reputation is spreading everywhere in the world due to its fruit (pitaya or pitahaya or dragon fruit), which is one of the most popular and widely used functional foods in the world. The fruit is a wealthy provenance of vitamins, minerals, antioxidants, and fiber. The ethno-pharmacological history of this genus indicated that it possesses antioxidant, anticancer, antimicrobial, hepato-protective, antihyperlipidemic, antidiabetic, and wound healing activities. Furthermore, it has been used for the treatment of cough, asthma, hyperactivity, tuberculosis, bronchitis, mumps, diabetes, and cervical lymph node tuberculosis. Different chemical constituents have been reported from this genus as betalains, flavonoids, phenolic acids, phenylpropanoids, triterpenes, sterols, fatty acids, etc. The current review focuses on the uses, botanical characterization, chemical constituents, nutritional importance, biological activities, and safety of Hylocereus species. Also, biosynthetic pathways of betalains have been discussed. Practical applicationsPitaya fruit is one of the most known fruit that is commercially grown in different countries of the world for its nutritional advantages. It has acquired a wide acceptance for its pharmacological actions against a variety of ailments. The present review revealed that pitaya contains various bioactive phytoconstituents which might participate directly or indirectly in their highlighted biological effects.Therefore, these compounds can be taken into account as favorable candidates for the development of effective and novel pharmaceutical leads. Deep phytochemical studies of pitaya fruit and its pharmacological effects, especially the mechanism of action of its constituents to clarify the relation between traditional uses and pharmacological activities will obviously be the focus of further research.

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“…Areal parts of A. cruentus and A. hybridus contained betacyanin of 40.4 and 6.4 mg amaranthin equivalent/100 g (FW) (Fresh Weight), respectively (Nana, Hilou, Millogo, & Nacoulma, ). Betacyanin is associated with numerous health benefits such as cytotoxic (Khan, ), neuroprotective (Wang & Yang, ), antidiabetic (Lugo‐Radillo, Delgado‐Enciso, & Pena‐Beltrãn, ), and hepatoprotective effects (Lee, Wettasinghe, Bolling, Ji, & Parkin, ).…”

Section: Dietary Phytochemicals In Traditional Leafy Vegetablesmentioning

confidence: 99%

A comprehensive review on beneficial dietary phytochemicals in common traditional Southern African leafy vegetables

Sivakumar

Chen

Sultanbawa

2018

Food Science & Nutrition

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Regular intake of sufficient amounts of certain dietary phytochemicals was proven to reduce the incidence of noncommunicable chronic diseases and certain infectious diseases. In addition, dietary phytochemicals were also reported to reduce the incidence of metabolic disorders such as obesity in children and adults. However, limited information is available, especially on dietary phytochemicals in the commonly available traditional leafy vegetables. Primarily, the review summarizes information on the major phytochemicals and the impact of geographical location, genotype, agronomy practices, postharvest storage, and processing of common traditional leafy vegetables. The review also briefly discusses the bioavailability and accessibility of major phytochemicals, common antinutritive compounds of the selected vegetables, and recently developed traditional leafy vegetable‐based food products for dietary diversification to improve the balanced diet for the consumers. The potential exists for better use of traditional leafy vegetables to sustain food security and to improve the health and well‐being of humans.

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Betanidin significantly reduces blood glucose levels in BALB/c mice fed with an atherogenic diet

Cited by 23 publications

References 15 publications

Plant Betalains: Safety, Antioxidant Activity, Clinical Efficacy, and Bioavailability

Plant Betalains: Safety, Antioxidant Activity, Clinical Efficacy, and Bioavailability

GenusHylocereus: Beneficial phytochemicals, nutritional importance, and biological relevance-A review

A comprehensive review on beneficial dietary phytochemicals in common traditional Southern African leafy vegetables

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