Betanin protects against bleomycin-induced pulmonary fibrosis by regulating the NLRP3/IL-1β/TGF-β1 pathway-mediated epithelial-to-mesenchymal transition

Abd Elrazik, Nesma A.; Helmy, Sahar A

doi:10.1039/d3fo03464j

Food Funct.

2024

DOI: 10.1039/d3fo03464j

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Betanin protects against bleomycin-induced pulmonary fibrosis by regulating the NLRP3/IL-1β/TGF-β1 pathway-mediated epithelial-to-mesenchymal transition

Nesma A. Abd Elrazik,

Sahar A Helmy

Abstract: The proposed mechanism of betanin protective effect against bleomycin-induced pulmonary fibrosis.

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Biological and pharmacological roles of pyroptosis in pulmonary inflammation and fibrosis: recent advances and future directions

Liu,

Wang,

Liu

et al. 2024

Cell Commun Signal

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Pyroptosis, an inflammatory regulated cell death (RCD) mechanism, is characterized by cellular swelling, membrane rupture, and subsequent discharge of cellular contents, exerting robust proinflammatory effects. Recent studies have significantly advanced our understanding of pyroptosis, revealing that it can be triggered through inflammasome- and caspase-independent pathways, and interacts intricately with other RCD pathways (e.g., pyroptosis, necroptosis, ferroptosis, and cuproptosis). The pathogenesis of pulmonary fibrosis (PF), including idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases, involves a multifaceted interplay of factors such as pathogen infections, environmental pollutants, genetic variations, and immune dysfunction. This chronic and progressive interstitial lung disease is characterized by persistent inflammation, extracellular matrix (ECM) accumulation, and fibrotic alveolar wall thickening, which potentially contribute to deteriorated lung function. Despite recent advances in understanding pyroptosis, the mechanisms by which it regulates PF are not entirely elucidated, and effective strategies to improve clinical outcomes remain unclear. This review strives to deliver a comprehensive overview of the biological functions and molecular mechanisms of pyroptosis, exploring its roles in the pathogenesis of PF. Furthermore, it examines potential biomarkers and therapeutic agents for anti-fibrotic treatments.

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Biological and pharmacological roles of pyroptosis in pulmonary inflammation and fibrosis: recent advances and future directions

Liu,

Wang,

Liu

et al. 2024

Cell Commun Signal

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Betanin protects against bleomycin-induced pulmonary fibrosis by regulating the NLRP3/IL-1β/TGF-β1 pathway-mediated epithelial-to-mesenchymal transition

Abstract: The proposed mechanism of betanin protective effect against bleomycin-induced pulmonary fibrosis.

Cited by 1 publication

References 52 publications

Biological and pharmacological roles of pyroptosis in pulmonary inflammation and fibrosis: recent advances and future directions

Biological and pharmacological roles of pyroptosis in pulmonary inflammation and fibrosis: recent advances and future directions

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