Betatrophin is correlated with glucagon and insulin release rather than insulin resistance marker in type 2 diabetes mellitus Iraqi women

Mohammed, Athir K.; Khazaal, Faris Ak

doi:10.18203/2320-6012.ijrms20163119

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…Mohammed and Khazaal., [19] suggested that betatrophin level had no statistically significant differences between non-diabetics and diabetics and serum betatrophin levels had no statistically significant positive or negative correlations with age, anthropometric, lipid profile,diabetic parameters. They explained the discrepancy between results depend on the following observations; first, duration of T 2 DM where investigators reported that people with longer duration of diabetes had greater betatrophin levels.…”

Section: Discussionmentioning

confidence: 93%

Study of Serum Betatrophin Level as A Novel Endocrinal Regulator Involved in Diabetic Nephropathy Development

El-Srougy

Hamam

2019

The Medical Journal of Cairo University

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Background: Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction and failure of various organs. Diabetic Nephropathy (DN) is the leading cause of chronic kidney disease which ultimately progresses to end stage renal disease. Therefore, early diagnostic markers for predicting and monitoring the progression of DN are needed to enable the timely administration of the mostly appropriate protective treatments, we hypothesized that betatrophin may be a novel endocrine regulator involved in DN development. Aim of Study: It was to examine circulating betatrophin level in patients with type 2 diabetes mellitus with or without diabetic nephropathy in comparison with healthy controls. Patients and Methods: The study was carried out on forty patients with type 2 diabetes mellitus. They were recruited from internal Medicine Department of Tanta University Hospital who classified into, 20 type 2 diabetic patients without nephropathy. 20 type 2 diabetic patients with nephropathy. Another twenty apparently healthy subjects were chosen from outpatient clinics of Tanta University Hospital and served as control group. This study was carried out from June 2016 to May 2017. An approval by Ethical Committee of Tanta University Faculty of Medicine was obtained. They were subjected to thorough history taking, clinical examination including anthropometric measurements (sex, age, BMI) and laboratory investigations including glycated Hb, fasting and post prandial blood glucose, liver function tests, UACR, kidney function, lipid profile, serum betatrophin estimation by ELISA. Results: Betatrophin was significantly higher in both T 2 DM with nephropathy and T 2 DM as compared to control group and significantly higher in T 2 DM with nephropathy than T 2 DM. There was significant positive correlation between betatrophin hormone and HbA 1 c, BMI, serum total cholesterol, serum triglycerides, LDL and negative correlation with HDL in both T 2 DM group and T 2 DM with nephropathy group. There was positive correlation between betatrophin and Albumin/Creatinine Ratio (ACR) in T2DM with nephropathy group.

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Section: Discussionmentioning

confidence: 93%

Study of Serum Betatrophin Level as A Novel Endocrinal Regulator Involved in Diabetic Nephropathy Development

El-Srougy

Hamam

2019

The Medical Journal of Cairo University

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“…Several studies in the literature examined the currently investigated markers to varying degrees. [31][32][33][34][35][36] In Kassahun et al study in Ethiopia, a cross-sectional study that examined 136 pregnant women (46 with PE), all women were in their third trimester, and NLR showed poor ability to differentiate between PE and control (AUC = 0.609); however, NLR was the best parameter in the study according to receiver operator curve analysis. [37] NLR serves as an indicator of both systemic inflammation and endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Role of hematological indices in predicting preeclampsia and its severity: retrospective case–control study

Al-Nuaimi

2024

Medicine

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Preeclampsia (PE) is a serious condition that threatens pregnancy with severe sequelae on both the mother and infant. Early detection of PE will lead to favorable outcomes, and using readily available markers like hematological indices is an attractive choice. Examine the diagnostic utility of hematological indices in pregnant women to predict preeclampsia and its severity. In a retrospective case–control study that included 252 women, all had their complete blood picture evaluated during their first and third trimesters as part of their outpatient antenatal care during their pregnancy. They were also divided into 3 groups: healthy pregnant women (control), non-severe PE, and severe PE, each involving 84 women. The changes in platelet to lymphocyte ratio (PLR) between 1st and 3rd trimesters showed an excellent ability to differentiate between severe PE and control (area under the curve = 0.954, cutoff ≤ ‐5.45%) and a good ability to differentiate between severe PE and non-severe PE (area under the curve = 0.841, cutoff ≤ ‐7.89%). Neutrophil to lymphocyte ratio showed a good to excellent ability to differentiate between severe PE and non-severe PE compared to control in the first and third trimesters and the percentage change between them. Changes in neutrophil to lymphocyte ratio and PLR strongly predict preeclampsia and its severity since they offer more predictive values than measuring NLP and PLR at different stages of pregnancy individually.

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Betatrophin is correlated with glucagon and insulin release rather than insulin resistance marker in type 2 diabetes mellitus Iraqi women

Cited by 2 publications

References 29 publications

Study of Serum Betatrophin Level as A Novel Endocrinal Regulator Involved in Diabetic Nephropathy Development

Study of Serum Betatrophin Level as A Novel Endocrinal Regulator Involved in Diabetic Nephropathy Development

Role of hematological indices in predicting preeclampsia and its severity: retrospective case–control study

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