Betavulgarin Isolated from Sugar Beet (Beta vulgaris) Suppresses Breast Cancer Stem Cells through Stat3 Signaling

Liu, Ren; Choi, Hack Sun; Xing, Zhen; Kim, Su‐Lim; Kim, Ji Hyang; Ko, Yu-Chan; Yun, Bong‐Sik; Lee, Dong‐Sun

doi:10.3390/molecules25132999

Cited by 10 publications

(3 citation statements)

References 36 publications

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“…This compound also reduced the proportion of the CD44 + /CD24 - subpopulation and the expression of the self-renewal-related genes such as c-Myc , Nanog and Oct4 . Interestingly, betavulgarin inhibited the Stat3/Sox2 signaling and induced breast cancer stem cell death [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

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Beetroot as a Potential Functional Food for Cancer Chemoprevention, a Narrative Review

Tan

Hamid

2021

J Cancer Prev

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Patients with cancer are prone to several debilitating effects due to chemotherapy or the disease itself. The behavioural disturbances experienced by patients with cancer include fatigue, insomnia, depression, and cognitive disturbances. These symptoms are very common and may persist for months or years even after completion of treatment and may affect patient's quality of life. Functional foods have long been linked to improve human performance and health, and hence are considered beneficial as part of the cancer patients' diet.Beetroot (Beta vulgaris L.) is one of high-nutrient vegetables used for salads and juices, and a valuable source of natural pigments. It belongs to the botanical order Amaranthaceae-Chenopodiaceae, which is cultivated commercially. Beetroot, also known as table or garden beet, is usually grown for its roots. It has a characteristic earthy mushy aroma and flavour, mainly due to the presence of geosmin, a volatile bicyclic alcoholic compound [1]. Beetroot is known for its antioxidant activities and widely used as a remedy for a variety of ailments including cardiovascular-related conditions, anemia, sexual weakness and bladder stones [2]. Some recent clinical studies have also indicated the usefulness of beetroot in managing blood pressure and cardiovascular health [3][4][5][6]. Beetroot has also gained popularity as a supplement to boost energy and improve performance in athletes [7][8][9][10].Interestingly, in the Traditional Persian Medicine practices, beetroot is one of the foods used in the prevention and managing of metastatic progression of cancer [11]. It is also widely used in other medicinal systems including the Arab, traditional Chinese and Ayurvedic medicine. Beetroot, juiced or blended, is a popular functional food among breast, prostate and colorectal cancer patients as reported in Trinidad. A study at two clinical sites on the island revealed that beetroot is being consumed by patients for the purpose of treatment, health improvement and amelioration of side effects associated with chemotherapy treatment [12]. Similarly, beetroot is also the most frequently used alternative dietetic measure among patients with cancer in Germany [13] and among a majority of gastrointestinal cancer patients in Serbia [14].

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Section: Discussionmentioning

confidence: 99%

“…Beetroot and Cancer http://www.jcpjournal.org Interestingly, betavulgarin inhibited the Stat3/Sox2 signaling and induced breast cancer stem cell death [71].…”

Section: Anti-proliferative and Other Chemopreventive Propertiesmentioning

confidence: 99%

Beetroot as a Potential Functional Food for Cancer Chemoprevention, a Narrative Review

Tan

Hamid

2021

J Cancer Prev

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“…Betanin, a type of betalain, has been shown to be an effective radical scavenging antioxidant [ 14 , 15 ] and anti-inflammatory compound [ 16 ]. Our group previously isolated the mammosphere formation inhibitor beta-vulgarin from beet [ 17 ]. Beta-vulgarin also functions against fungi [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

5-Hydroxymaltol Derived from Beetroot Juice through Lactobacillus Fermentation Suppresses Inflammatory Effect and Oxidant Stress via Regulating NF-kB, MAPKs Pathway and NRF2/HO-1 Expression

Kim

Choi

et al. 2021

Antioxidants

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Inflammation is the first response of the immune system against bacterial pathogens. This study isolated and examined an antioxidant derived from Lactobacillus fermentation products using cultured media with 1% beet powder. The antioxidant activity of the beet culture media was significantly high. Antioxidant activity-guided purification and repeated sample isolation yielded an isolated compound, which was identified as 5-hydoxymaltol using nuclear magnetic resonance spectrometry. We examined the mechanism of its protective effect on lipopolysaccharide (LPS)-induced inflammation of macrophages. 5-Hydroxymaltol suppressed nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells. It also suppressed tumor necrosis factor α (TNF-α), interleukin (IL)-1β, and inducible nitric oxide synthase (iNOS) in the messenger RNA and protein levels in LPS-treated RAW 264.7 cells. Moreover, it suppressed LPS-induced nuclear translocation of NF-κB (p65) and mitogen-activated protein kinase activation. Furthermore, 5-hydroxymaltol reduced LPS-induced reactive oxygen species (ROS) production as well as increased nuclear factor erythroid 2–related factor 2 and heme oxygenase 1 expression. Overall, this study found that 5-hydroxymaltol has anti-inflammatory activities in LPS-stimulated RAW 264.7 macrophage cells based on its inhibition of pro-inflammatory cytokine production depending on the nuclear factor κB signaling pathway, inhibition of LPS-induced reactive oxygen species production, inhibition of LPS-induced mitogen-activated protein kinase induction, and induction of the nuclear factor erythroid 2–related factor 2/heme oxygenase 1 signaling pathway. Our data showed that 5-hydroxymaltol may be an effective compound for treating inflammation-mediated diseases.

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Transcriptional co-activators YAP/TAZ: Potential therapeutic targets for metastatic breast cancer

Zhao

Wang

Cai

et al. 2021

Biomedicine & Pharmacotherapy

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Betavulgarin Isolated from Sugar Beet (Beta vulgaris) Suppresses Breast Cancer Stem Cells through Stat3 Signaling

Cited by 10 publications

References 36 publications

Beetroot as a Potential Functional Food for Cancer Chemoprevention, a Narrative Review

Beetroot as a Potential Functional Food for Cancer Chemoprevention, a Narrative Review

5-Hydroxymaltol Derived from Beetroot Juice through Lactobacillus Fermentation Suppresses Inflammatory Effect and Oxidant Stress via Regulating NF-kB, MAPKs Pathway and NRF2/HO-1 Expression

Transcriptional co-activators YAP/TAZ: Potential therapeutic targets for metastatic breast cancer

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