Beteiligung der glatten Muskulatur bei Dermatomyositis. I

Kleine-Natrop, H E; Engel, Sinah

doi:10.1007/bf00520175

Cited by 1 publication

(3 citation statements)

References 6 publications

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“…IIM can result in impairment of the oral [29,[58][59][60][61][62][63][64], pharyngeal [7,23,24,27,29,[31][32][33]44, and esophageal [24,29,38,59,62,73,81,85,89,90,93,95,98,99,101,[103][104][105]112,[114][115][116][117][118][119][120][121][122][123][124][125][126][127][128][129]…”

Section: Inflammation Of Swallowing Musclesmentioning

confidence: 99%

“…Reduced pharyngeal contractility can result in insufficient pharyngeal bolus clearance [139]. Consequently, myositis patients often show pharyngeal residue after swallowing [7,27,29,31,33,44,[58][59][60][61][65][66][67]69,71,[73][74][75][76][77][78][79][80]83,84,86,87,91,93,96,100,101,103,104,106,111,112,115]. These can impact on swallowing safety and ultimately cause aspiration, which is a frequently reported finding [33,78,81,86].…”

Section: Dysphagia Pathologymentioning

confidence: 99%

“…This may be explained by the fact that muscle physiology is affected in a different way during the acute inflammatory phase compared to the chronic phase when fibrosis occurs [82]. Cricopharyngeal hypercontractility often leads to an opening or relaxation disorder of the UES, resulting in pronounced residue or pooling of saliva in the piriform sinus [7,27,31,33,[65][66][67]69,73,74,[76][77][78]80,86,87,101,103,106,111,112,115], which is located directly above the UES. Typical findings in VFSS are a prominent cricopharyngeus muscle, also referred to as cricopharyngeal bar [23,32,61,68,86,91,93,97,99,106] and muscle propulsions or posterior indentations between C3 and C7 [7,71,96].…”

Section: Dysphagia Pathologymentioning

confidence: 99%

See 2 more Smart Citations

The Impact of Dysphagia in Myositis: A Systematic Review and Meta-Analysis

Labeit

Pawlitzki

Ruck

et al. 2020

JCM

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(1) Background: Dysphagia is a clinical hallmark and part of the current American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) diagnostic criteria for idiopathic inflammatory myopathy (IIM). However, the data on dysphagia in IIM are heterogenous and partly conflicting. The aim of this study was to conduct a systematic review on epidemiology, pathophysiology, outcome and therapy and a meta-analysis on the prevalence of dysphagia in IIM. (2) Methods: Medline was systematically searched for all relevant articles. A random effect model was chosen to estimate the pooled prevalence of dysphagia in the overall cohort of patients with IIM and in different subgroups. (3) Results: 234 studies were included in the review and 116 (10,382 subjects) in the meta-analysis. Dysphagia can occur as initial or sole symptom. The overall pooled prevalence estimate in IIM was 36% and with 56% particularly high in inclusion body myositis. The prevalence estimate was significantly higher in patients with cancer-associated myositis and with NXP2 autoantibodies. Dysphagia is caused by inflammatory involvement of the swallowing muscles, which can lead to reduced pharyngeal contractility, cricopharyngeal dysfunction, reduced laryngeal elevation and hypomotility of the esophagus. Swallowing disorders not only impair the quality of life but can lead to serious complications such as aspiration pneumonia, thus increasing mortality. Beneficial treatment approaches reported include immunomodulatory therapy, the treatment of associated malignant diseases or interventional procedures targeting the cricopharyngeal muscle such as myotomy, dilatation or botulinum toxin injections. (4) Conclusion: Dysphagia should be included as a therapeutic target, especially in the outlined high-risk groups.

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