Betel Leaf Extract Amends Dehydroepiandrosterone Induced PCOS Related Hormonal Abnormality and Histopathological Alterations in Rat Model

Sunand, Katta; Yellow, Mahipal; Naveen, P; Deepika, Yasho; Mohan, G. Krishna; Bakshi, Vasudha

doi:10.5530/pj.2019.11.223

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…Low progesterone levels cause anovulation. Higher plasma androgen and lower estrogen and progesterone concentrations have been observed in PCOS patients [ 9 ]. Hyperandrogenism is caused by the overproduction of ovarian androgens due to insulin resistance with hyperinsulinemia in PCOS females.…”

Section: Discussionmentioning

confidence: 99%

“…Regular treatment of mice with DHEA led to an increase in plasma cholesterol and triglycerides compared to Group I ( p < 0.01). Biochemical analysis of PCOS patients reveals dyslipidemia, characterized by a lipid profile that is out of whack: low HDL, higher triglycerides (TG), higher total cholesterol, and higher low-density lipoprotein (LDL) [ 9 ]. Dyslipidemia, characterized by increased TGs and decreased HDL cholesterol, is commonly observed in PCOS.…”

Section: Discussionmentioning

confidence: 99%

“…The primary and realistic objectives of therapy in PCOS are fertility restoration, insulin resistance (IR) improvement, acne and hirsutism management, menstrual cycle regularization, and endometrial hyperplasia prevention [ 8 ]. Hot flashes, arthritis, joint or muscle discomfort, irritability, mood swings, melancholy, and bloating are some of the psychological and physiological side effects of contemporary PCOS treatment that can range from mild to severe [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Medicines produced from natural sources may be an impressive substitute therapy with a familiar mechanism of action for the creation of a powerful, safe, and cost-effective treatment agent for this ailment [ 9 ]. However, so far, there is scant scientific basis for the claims that complementary and alternative therapies are both safe and effective.…”

Section: Introductionmentioning

confidence: 99%

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Regulation of Insulin Resistance, Lipid Profile and Glucose Metabolism Associated with Polycystic Ovary Syndrome by Tinospora cordifolia

Rani,

Chitme,

Kukreti

et al. 2023

Nutrients

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Background: The plant Tinospora cordifolia (TC), traditionally known as guduchi or giloy, is used for a number of health conditions as a nutritional supplement and rejuvenation medicine. Its nutritional supplementary products are traditionally recommended for a wide range of health issues, including diabetes, menstruation discomfort, fever, obesity, inflammation, and more. Unfortunately, there has not been extensive research into its effectiveness in treating or managing insulin resistance, lipid and carbohydrate metabolism, hormonal imbalance, and metabolic syndrome-associated polycystic ovary syndrome (PCOS). Methods: Consequently, the present study was designed to induce insulin resistance, dyslipidemia, hormonal abnormality, hyperglycemia, and menstrual disturbance of PCOS using dehydroepiandrosterone (DHEA) in mice and study the effect of oral TC extracts on these factors by using ancient and modern technologies. During the 21-day study, 6 mg/100 g/day of DHEA was given to female mice. Levels of glucose, insulin, lipids, and hormones were estimated. In addition to being seen with the naked eye, the morphological and microscopic changes were also observed on histology slides. Results: The study outcomes show that pretreatment with TC preparations significantly improved biochemical and histological abnormalities in female mice. Diestrus phase was only observed in DHEA-treated animals, while cornified epithelial cells were present in TC-treated mice. Pretreatment with TC satva showed significant (p < 0.001) reductions in body weight compared to placebo. Fasting blood glucose, 1-h OGTT, and 2-h OGTT levels were all significantly lower in TC satva- and oil-treated animals in comparison to the disease control group (p < 0.001). Treatment with TC extracts resulted in a normalization of estradiol, progesterone, and testosterone levels (p < 0.05). Treatment with TC extract improved lipid profiles (p < 0.001), LH/FSH ratios (p < 0.01), fasting insulin levels (p < 0.001), HOMA-IR (p < 0.001), HOMA-Beta (p < 0.001), and QUICKI (p < 0.001). Both macroscopic and microscopic alterations were seen to be restored after TC extract treatment. After being treated with TC satva, oil, and hydroalcoholic extract, the severity of PCOS decreased by 54.86%. Conclusions: These findings lead us to the conclusion that TC extracts and satva as nutritional supplements are useful for treating PCOS and associated symptoms. It is recommended that additional research be conducted to determine the molecular mechanism of action of TC nutritional supplements on PCOS-related changes in metabolic profiles. We also recommend further clinical studies to explore the clinical efficacy and effectiveness of TC nutritional supplements in treating and/or managing PCOS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Regulation of Insulin Resistance, Lipid Profile and Glucose Metabolism Associated with Polycystic Ovary Syndrome by Tinospora cordifolia

Rani,

Chitme,

Kukreti

et al. 2023

Nutrients

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Role of polyherbal formulations in the management of Polycystic ovarian syndrome

Madireddy,

Wadhwa,

Singh

et al. 2023

The Fourth Scientific Conference for Electrical Engineering Techniques Research (Eetr2022)

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A Systemic Review of Pre-clinical Studies of Herbal Plants having Anti-Polycystic Ovarian Syndrome Activity: A PAN-India Study

Karmakar,

Chakraborty,

Hussain

et al. 2025

NPJ

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Background: Polycystic ovarian syndrome (PCOS) is a prevalent endocrine and metabolic condition seen in premenopausal women. A number of pharmacological agents like metformin, oral contraceptives, and anti-androgen agents have been used to treat PCOS and its associated implications, but it has been associated with numerous negative effects like fatal and nonfatal lactic acidosis, weight gain, cardiovascular, and hepatic toxicity. Methodology: This study considered the Preferred Reporting Items for Systematic Review and Meta- Analysis (PRISMA) guideline where a vast number of article sources from different scientific databases like Google Scholar (https://scholar.google.com/), PubMed (https://pubmed.ncbi.nlm.nih.gov/), and Web of Science (https://mjl.clarivate.com/search-results) were screened out. Results: From a total of 154 studies, 24 studies were screened out following the inclusion and exclusion criteria, which reported 24 different plants that were used against PCOS preclinically. Details of various plants used, including their respective families, plant parts utilized, extraction methods employed, formulations developed, animal models of polycystic ovary syndrome (PCOS) utilized, and the geographical locations within India where the research has been conducted are all documented. Conclusion: This systematic review is the first in India to report the pre-clinical studies of medicinal plants against PCOS, and it provides a thorough summary of the application of medicinal plants for the management of PCOS. Nonetheless, molecular level investigations on the plants utilized, their bioactive phytoconstituent responsible for the anti-PCOS activity, the probable mechanism of action and the pathway through which they conserve their effect, the effective dose, and the potential adverse effects are the need of time.

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Betel Leaf Extract Amends Dehydroepiandrosterone Induced PCOS Related Hormonal Abnormality and Histopathological Alterations in Rat Model

Cited by 3 publications

References 16 publications

Regulation of Insulin Resistance, Lipid Profile and Glucose Metabolism Associated with Polycystic Ovary Syndrome by Tinospora cordifolia

Regulation of Insulin Resistance, Lipid Profile and Glucose Metabolism Associated with Polycystic Ovary Syndrome by Tinospora cordifolia

Role of polyherbal formulations in the management of Polycystic ovarian syndrome

A Systemic Review of Pre-clinical Studies of Herbal Plants having Anti-Polycystic Ovarian Syndrome Activity: A PAN-India Study

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