Betel quid use in relation to infectious disease outcomes in Cambodia

Singh, Pramil N.; Natto, Zuhair S.; Yel, Daravuth; Job, Jayakaran S.; Knutsen, Synnøve F.

doi:10.1016/j.ijid.2011.12.006

Cited by 23 publications

(21 citation statements)

References 39 publications

(47 reference statements)

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“…Finally, in the same sample of Cambodian women that we studied, Singh et al 40 have recently reported an association between female betel quid use and infectious disease (HIV/AIDs, typhoid, dengue fever, and malaria). The link was not thought to be directly causal but rather a consequence of the effect of this habit on suppressing the immune system and, through constant injury to the oral mucosa, providing a route of entry for the pathogen.…”

Section: Discussionmentioning

confidence: 55%

Maternal Use of Cigarettes, Pipes, and Smokeless Tobacco Associated With Higher Infant Mortality Rates in Cambodia

Singh

Eng

Yel³

et al. 2013

Asia Pac J Public Health

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In the Western Pacific Region, rural women use loose tobacco in betel quid chewing and pipe smoking. We examined the relation between maternal use of tobacco and infant mortality (IM) in a national sample of 24 296 birth outcomes in adult women (n = 6013) in Cambodia. We found that (1) age-adjusted odds of IM were higher for maternal use of any tobacco (odds ratio [OR] = 1.69; 95% confidence interval [CI] = 1.27–2.26); (2) age-adjusted odds of IM were higher for cigarette use (OR = 2.54; 95% CI = 1.54–4.1), use of pipes (OR = 3.09; [95% CI = 1.86–5.11]), and betel quid chewing (OR = 1.55; 95% CI = 1.10–2.17); and (3) these associations remained after multivariable adjustment for environmental tobacco smoke, malnutrition, ethnicity, religion, marital status, education, income, occupation, and urban/rural dwelling. In addition to finding the established association with cigarettes, we also found that maternal use of smokeless tobacco and pipes was associated with higher rates of infant death in Cambodia.

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Section: Discussionmentioning

confidence: 55%

Maternal Use of Cigarettes, Pipes, and Smokeless Tobacco Associated With Higher Infant Mortality Rates in Cambodia

Singh

Eng

Yel³

et al. 2013

Asia Pac J Public Health

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“…Among women and ethnic minorities of Cambodia and the region there is also a possible link between non-cigarette forms of tobacco (i.e. betel quid, waterpipe) and TB and/or lung damage [10,33,34]. …”

Section: Discussionmentioning

confidence: 99%

Cigarette smoking and tuberculosis in Cambodia: findings from a national sample

Singh¹,

Yel²,

Kheam³

et al. 2013

Tobacco Induced Diseases

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Background: Cambodia has very high rates of tuberculosis and smoked tobacco use among adults. Efforts to control both tobacco use and tuberculosis in Cambodia need to be informed by nationally representative data. Our objective is to examine the relation between daily cigarette smoking and lifetime tuberculosis (TB) history in a national sample of adults in Cambodia. 2) a non-significant 58% increase in odds of ever having being diagnosed with TB among men who smoked manufactured cigarettes (OR = 1.58 [95% CI 0.97, 2.58]).

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“…The latter is frequently shared between chewers; this, and mucosal inflammation secondary to chewing, may facilitate pneumococcal colonization. Chewing has already been associated with tuberculosis (42).…”

Section: Discussionmentioning

confidence: 99%

Impact of Intermittent Preventive Treatment in Pregnancy with Azithromycin-Containing Regimens on Maternal Nasopharyngeal Carriage and Antibiotic Sensitivity of Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus: a Cross-Sectional Survey at Delivery

et al. 2015

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Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) can prevent low birth weight (LBW; Ͻ2,500 g) and reduces infant morbidity and mortality in resource-limited countries (1, 2). However, high-level resistance of Plasmodium falciparum to SP, recently observed in East Africa, may render IPTp-SP clinically inefficacious (3-5). The development and evaluation of new IPTp regimens are therefore of utmost importance (6, 7).Azithromycin (AZ) is a broad-spectrum macrolide (azalide) antibiotic with favorable antimalarial properties and a good safety profile in pregnancy (8, 9). IPTp with SPAZ prevented LBW and preterm delivery in two clinical trials (10, 11), and confounding may in part explain the observation of no effect in the third (6, 12); this warrants its further evaluation as a potential alternative to SP-IPTp.An integral part of such evaluation is to screen for adverse consequences, including the selection of drug-resistant Streptococcus pneumoniae (13), a principal cause of meningitis and respiratory infections in infants (14). Mass administration (MDA) of AZ to children has been associated with increased nasopharyngeal carriage of macrolide-resistant pneumococci, particularly when MDA was given at 6-to 12-monthly intervals (15)(16)(17)(18)(19)(20). However, this is not a unanimous finding (21) and may in part depend on the prevalence of resistant isolates at baseline (15-18). Longitudinal studies of carriage and resistance patterns indicate that in the event of MDA-driven temporary expansion of macrolide-resistant isolates, a decrease in their prevalence tends to occur 12 to 24 months after the most recent treatment (19,20). Citation Unger HW, Aho C, Ome-Kaius M, Wangnapi RA, Umbers AJ, Jack W, Lafana A, Michael A, Hanieh S, Siba P, Mueller I, Greenhill AR, Rogerson SJ. 2015. Impact of intermittent preventive treatment in pregnancy with azithromycincontaining regimens on maternal nasopharyngeal carriage and antibiotic sensitivity of Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus: a cross-sectional survey at delivery.

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Betel quid use in relation to infectious disease outcomes in Cambodia

Cited by 23 publications

References 39 publications

Maternal Use of Cigarettes, Pipes, and Smokeless Tobacco Associated With Higher Infant Mortality Rates in Cambodia

Maternal Use of Cigarettes, Pipes, and Smokeless Tobacco Associated With Higher Infant Mortality Rates in Cambodia

Cigarette smoking and tuberculosis in Cambodia: findings from a national sample

Impact of Intermittent Preventive Treatment in Pregnancy with Azithromycin-Containing Regimens on Maternal Nasopharyngeal Carriage and Antibiotic Sensitivity of Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus: a Cross-Sectional Survey at Delivery

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