Betelvine (Piper betle L.): A potential source for oral care

Chowdhury, Uttam Kumar; Baruah, Pradip Kumar

doi:10.25081/cb.2020.v11.6130

Cited by 8 publications

(7 citation statements)

References 41 publications

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“…There are chewing habit practices of betel leaves in many countries which are believed beneficial for avoiding bad breath, strengthening the gum, preserving the teeth, and stimulating the digestive system [ 1 , 2 ]. In traditional medicine practices, betel leaves are used for vaginal douching in Indonesia [ 3 ], as a gargle mouthwash in India and Thailand [ 4 ], and as a treatment for dental problems, headaches, arthritis, and joint pain in Malaysia [ 1 ]. In Srilanka, the betel leaf juice is used to treat skin ailments [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Piper betle (L): Recent Review of Antibacterial and Antifungal Properties, Safety Profiles, and Commercial Applications

et al. 2021

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Piper betle (L) is a popular medicinal plant in Asia. Plant leaves have been used as a traditional medicine to treat various health conditions. It is highly abundant and inexpensive, therefore promoting further research and industrialization development, including in the food and pharmaceutical industries. Articles published from 2010 to 2020 were reviewed in detail to show recent updates on the antibacterial and antifungal properties of betel leaves. This current review showed that betel leaves extract, essential oil, preparations, and isolates could inhibit microbial growth and kill various Gram-negative and Gram-positive bacteria as well as fungal species, including those that are multidrug-resistant and cause serious infectious diseases. P. betle leaves displayed high efficiency on Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa, Gram-positive bacteria such as Staphylococcus aureus, and Candida albicans. The ratio of MBC/MIC indicated bactericidal and bacteriostatic effects of P. betle leaves, while MFC/MIC values showed fungicidal and fungistatic effects. This review also provides a list of phytochemical compounds in betel leaves extracts and essential oils, safety profiles, and value-added products of betel leaves. Some studies also showed that the combination of betel leaves extract and essential oil with antibiotics (streptomycin, chloramphenicol and gentamicin) could provide potentiating antibacterial properties. Moreover, this review delivers a scientific resume for researchers in respected areas and manufacturers who want to develop betel leaves-based products.

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Section: Introductionmentioning

confidence: 99%

Piper betle (L): Recent Review of Antibacterial and Antifungal Properties, Safety Profiles, and Commercial Applications

et al. 2021

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“…The betel leaf also shows another most important anticarcinogenic property due to having polyphenol compounds. The presence of bioactive components such as chlorogenic and hydroxychavicol bioactive are ruin carcinogenic of tobacco 23 . Due to phenolic compounds, betel leaf is known as herbal medicine.…”

Section: Anti-cancer Propertiesmentioning

confidence: 99%

An overview of betel leaf: Green gold of India

Kirve

2024

J Pharmacogn Phytochem

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Betel leaf is a traditional nutritional and medicinal food plant known as Paan. Paan is the name given to the vivid green fresh leaves of the betel vine. Piper betle L. belonging to Piperaceae family, known as a traditional herbal medicinal plant and used for several health benefits in Asian countries. The scientific information of betel leaf nutrition values and health benefits are crucial for raising betel leaf consumption in daily life. Piper betle L. is also known as a Neglected Green Gold of India with a higher nutritional and dietary value such as fiber, vitamins, and minerals. Regarding the nutritional and therapeutic properties of betel leaf, around 15-20 million people in India take it regularly. Furthermore, several phytochemicals and nutritional components are found in the betel leaf, which is recognized as a bioactive compound (BAC). These compounds have several significant pharmacological properties, in which antimicrobial, antidiabetic, antiulcer, anti-inflammatory, anticancer, antimutagenic, and antioxidant properties are crucial once. The present review provides information on betel plant including colour categories, varieties, phytochemistry, extraction techniques, health benefits and their biological activities.

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“…P. betle leaves are traditionally used to treat vaginal and oral anti-candidiasis, halitosis, and conjunctivitis in Indonesia [ 16 , 17 ]. In Thailand, it is widely used as a mouthwash to prevent bad breath [ 18 ]. In Malaysia, P. betle is considered a crucial traditional medicine for treating dental problems, headaches, and joint issues.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory and anti-adherent effects of Piper betle L. leaf extract against Acanthamoeba triangularis in co-infection with Staphylococcus aureus and Pseudomonas aeruginosa: A sustainable one-health approach

Kwankaew,

Sangkanu,

Mitsuwan

et al. 2024

Vet World

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Background and Aim: Keratitis is a serious ocular infection often caused by pathogenic micro-organisms such as Acanthamoeba spp. Among other harmful microbes, Acanthamoeba keratitis presents a particular challenge due to its resistance to conventional antimicrobial agents. Piper betle Linn., commonly known as betel leaf, has been traditionally used for its medicinal properties. This study aimed to assess the potential of the leaf ethanol extract of P. betle Linn. in the treatment of Acanthamoeba triangularis in monoculture and co-culture with two prevalent pathogenic bacteria, Staphylococcus aureus and Pseudomonas aeruginosa, associated with keratitis. Materials and Methods: Minimum inhibitory concentrations (MICs) of A. triangularis, S. aureus, and P. aeruginosa extracts in monoculture and coinfected conditions were examined. In addition, this study explored the potential of the extract in preventing Acanthamoeba adherence in both monoculture and co-culture environments. Scanning electron microscopy (SEM) analysis confirmed the impact of the extract on Acanthamoeba cell membranes, including acanthopodia. Furthermore, a time-kill kinetic assay was used to validate the amoebicidal activity of the extract against A. triangularis and the tested bacteria. Results: MICs for trophozoites, cysts, P. aeruginosa, and S. aureus in the monoculture were 0.25, 0.25, 0.51, and 0.128 mg/mL, respectively, whereas the MICs for Acanthamoeba coinfected with bacteria were higher than those in the monoculture. This extract inhibited the growth of A. triangularis trophozoites and cysts for up to 72 h. Moreover, P. betle extract effectively prevented the adherence of Acanthamoeba to contact lenses under monoculture conditions. SEM analysis confirmed that P. betle extract affects the cell membrane of Acanthamoeba, including Acanthopodia. In addition, the time-kill kinetic assay confirmed that the extract contained amoebicidal activity against A. triangularis, including the tested bacteria. Notably, S. aureus was more susceptible than A. triangularis and P. aeruginosa to P. betle extract treatment. Unexpectedly, our study revealed that S. aureus negatively affected A. triangularis in the co-culture after 3 days of incubation, whereas P. aeruginosa facilitated the growth of A. triangularis in the presence of the extract. Conclusion: This study provides compelling evidence of the anti-adhesive and anti-Acanthamoeba properties of P. betle leaf extract against A. triangularis under monoculture and co-culture conditions. The observed impact on Acanthamoeba cell membranes, coupled with the time-kill kinetic assay results, underscores the potential of P. betle leaf extract as a promising agent for combating Acanthamoeba-related infections in humans and animals. Keywords: Piper betle extract, Acanthamoeba triangularis, co-infection, keratitis, Pseudomonas aeruginosa, Staphylococcus aureus.

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Betelvine (Piper betle L.): A potential source for oral care

Cited by 8 publications

References 41 publications

Piper betle (L): Recent Review of Antibacterial and Antifungal Properties, Safety Profiles, and Commercial Applications

Piper betle (L): Recent Review of Antibacterial and Antifungal Properties, Safety Profiles, and Commercial Applications

An overview of betel leaf: Green gold of India

Inhibitory and anti-adherent effects of Piper betle L. leaf extract against Acanthamoeba triangularis in co-infection with Staphylococcus aureus and Pseudomonas aeruginosa: A sustainable one-health approach

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