Bethesda thyroid categories and family history of thyroid disease

Kust, Davor; Staničić, Josip; Mateša, Neven

doi:10.1111/cen.13538

Cited by 14 publications

(19 citation statements)

References 13 publications

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“…Although controversial, the use of statins suggests that these patients already have an increased CVR. Even though, in one study, 34 the authors demonstrated that each 10% reduction in LDL-C was estimated to reduce IMT by 0.73% per year (95% CI, 0.27 to 1.19), the use of statins was not sufficient to prevent the reclassification to a higher cardiovascular risk group in our population of patients with asymptomatic T2DM. However, it is important to note that only 40.3% of patients were within the recommended LDL goal for high-risk patients according to the current Brazilian Cardiovascular Risk Prevention guidelines.…”

Section: Overview Of Demographic and Laboratory Data Of The Studied Pmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, considering the amplitude of the confidence interval and the missing relevant data in the literature to corroborate this association, more studies are needed to assess the influence of FH of thyroid disease in the stratification of CVR. The FH of thyroid disease is best documented in cases of differentiated thyroid cancer (DTC), 34 which are mainly sporadic. In this condition, FH of thyroid disease is also considered a risk factor for familial tumors and may account for 5% to 15% of the cases.…”

Section: Overview Of Demographic and Laboratory Data Of The Studied Pmentioning

confidence: 99%

“…In this condition, FH of thyroid disease is also considered a risk factor for familial tumors and may account for 5% to 15% of the cases. 34 In spite of that, it is important to emphasize that both FH of CHD and FH of thyroid disease were selfreported. The increase in free T4 within the normal range was associated with a lower chance of classification in the riskincreasing group.…”

Section: Overview Of Demographic and Laboratory Data Of The Studied Pmentioning

confidence: 99%

“…Another potential limitation was the reliance on self-reported FH of premature CAD and of thyroid disease, although most studies addressed this in the same way. 34 The variation of CVR in 5% for men and 2.5% for women can also be considered a limitation because, no data in the literature to validate this variation were found. Furthermore, considering that our study was a cross-sectional one, the causal relationship among the studied variables and CVR estimated by CA or VA could not be established.…”

Section: Overview Of Demographic and Laboratory Data Of The Studied Pmentioning

confidence: 99%

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<p>Vascular Age as a Cardiovascular Risk Marker in Asymptomatic Patients with Type 2 Diabetes</p>

Palma¹,

Lopes²,

Silva³

et al. 2020

DMSO

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Aim: There is a wide variety of cardiovascular outcomes in patients with type 2 diabetes (T2DM), even in asymptomatic individuals. Carotid intima-media thickness (CIMT) is a marker of subclinical atherosclerosis and can be considered as a predictor of cardiovascular risk (CVR). The aim of this study was to evaluate the relationship between CIMT-determined vascular age (VA), CVR scores, and thyroid function in asymptomatic patients with T2DM. Patients and Methods: Clinical laboratory and CIMT parameters were measured in 154 asymptomatic patients with T2DM. The Framingham risk score (FRS) was performed with chronological age (CA) and with VA. A multinomial logistic regression model was used to analyze variables related to CVR reclassification. Results: The use of CIMT-determined VA led to the reclassification of 54 (35.52%) out of 152 asymptomatic T2DM patients, being 20 (37.03%) to a lower categorical risk and 34 (62.96%) to a higher categorical risk according to FRS. The variables that were associated to reclassification to a higher categorical risk were positive family history (FH) of premature coronary artery disease (p=0.046), FH of thyroid disease (p=0.010), use of statins (p=0.027), and free T4 levels (p=0.009). Conclusion: VA determined from CIMT allowed the reclassification of the CVR in asymptomatic T2DM patients. FH of premature CAD, FH of known thyroid disease, use of statins, and free T4 levels were associated to a reclassification into a higher risk category. The use of doppler to perform CIMT measure is currently more accessible, especially in a low-middle income country like Brazil. However, further prospective studies must be performed to establish the predictive values of CIMT on atherosclerosis and how thyroid function acts like cardiovascular risk marker on CVR scores.

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Section: Overview Of Demographic and Laboratory Data Of The Studied Pmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Overview Of Demographic and Laboratory Data Of The Studied Pmentioning

confidence: 99%

Section: Overview Of Demographic and Laboratory Data Of The Studied Pmentioning

confidence: 99%

Section: Overview Of Demographic and Laboratory Data Of The Studied Pmentioning

confidence: 99%

See 3 more Smart Citations

<p>Vascular Age as a Cardiovascular Risk Marker in Asymptomatic Patients with Type 2 Diabetes</p>

Palma¹,

Lopes²,

Silva³

et al. 2020

DMSO

View full text Add to dashboard Cite

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Classification of Thyroid Diseases

Corbetta

2021

Thyroid, Obesity and Metabolism

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The impact of thyroid tumor features on lymph node metastasis in papillary thyroid carcinoma patients in head and neck department at KAMC: A retrospective cross-sectional study

Aljohani

Merdad

Alserif

et al. 2021

Annals of Medicine &Amp; Surgery

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Introduction Papillary thyroid carcinoma (PTC) is the most prevalent type of thyroid cancer. It is one of the most common types of malignancy of the thyroid that spreads to cervical lymph nodes. Lymph node metastasis (LNM) is an important factor when determining recurrence risk, and determining the extent of lymph node involvement can guide treatment. Our main objective is to evaluate the association between the size of the tumor and the number of lymph node metastases in patients with PTC. Methods: We conducted an electronic retrospective chart review of 125 patients with PTC followed in the Head and Neck Department at KAMC from 2009 to 2020. Twenty-two patients included in our study were pathologically and clinically diagnosed and confirmed to have LNM of PTC. Results: The study included 22 PTC patients who had undergone lymph node dissections. Patients had a median age of 38.8 years (IQR = 32.2–54.5), and the median tumor size was 20.5 mm. The most commonly affected level of the neck was IV (76.2%). Distant metastasis M1 was seen in only two patients (9.1%). Tumors sizes >30mm (75%) had ≥5 LNM. Most cases were the classic subtype PTC. For the site of the tumor, the site had a significant impact on the number of LNM (p = 0.004). Multifocality had a high impact on LNM (p = 0.019). Conclusions: This study showed no association between the size of PTC and the number of LNMs. The bilaterality of PTC was significantly associated with a high number of LNMs.

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Bethesda thyroid categories and family history of thyroid disease

Cited by 14 publications

References 13 publications

<p>Vascular Age as a Cardiovascular Risk Marker in Asymptomatic Patients with Type 2 Diabetes</p>

<p>Vascular Age as a Cardiovascular Risk Marker in Asymptomatic Patients with Type 2 Diabetes</p>

Classification of Thyroid Diseases

The impact of thyroid tumor features on lymph node metastasis in papillary thyroid carcinoma patients in head and neck department at KAMC: A retrospective cross-sectional study

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