Better characterization of attention and hyperactivity/impulsivity in children with ADHD: The key to understanding the underlying white matter microstructure

Gagnon, Anthony; Descoteaux, Maxime; Bocti, Christian; Takser, Larissa

doi:10.1016/j.pscychresns.2022.111568

Cited by 4 publications

(2 citation statements)

References 78 publications

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“…In previous studies, the researchers found that ADHD patients had abnormal development of gray matter in the basal ganglia, abnormal development of white matter in the frontal and temporal lobes of the brain, and abnormal brain network connections (Cortese et al., 2021; De La Fuente et al., 2013; Gagnon et al., 2022; Klein et al., 2021; Parlatini et al., 2023; Schmithorst et al., 2016; Vilgis et al., 2016; Wu et al., 2020; Zhao et al., 2020, 2022). In this study, we found white matter abnormalities in frontal lobe, temporal lobe, and other brain areas in ADHD children, we also found gray matter abnormalities in caudate nucleus in ADHD children.…”

Section: Discussionmentioning

confidence: 99%

Diffusion kurtosis imaging reveals abnormal gray matter and white matter development in some brain regions of children with attention‐deficit/hyperactivity disorder

Tang,

Liu,

Nie

et al. 2023

J of Neuroscience Research

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In this study, we explored the application of diffusion kurtosis imaging (DKI) technology in the brains of children with attention‐deficit/hyperactivity disorder (ADHD). Seventy‐two children with ADHD and 79 age‐ and sex‐matched healthy controls were included in the study. All children were examined by means of 3D T1‐weighted image, DKI, and conventional sequence scanning. The volume and DKI parameters of each brain region were obtained by software postprocessing (GE ADW 4.6 workstation) and compared between the two groups of children to determine the imaging characteristics of children with ADHD. The result showed the total brain volume was lower in children with ADHD than in healthy children (p < .05). The gray and white matter volumes in the frontal lobe, temporal lobe, hippocampus, caudate nucleus, putamen, globus pallidus, and other brain regions were lower in children with ADHD than in healthy children (p < .05). The axial kurtosis (Ka), mean kurtosis (MK), fractional anisotropy (FA), and radial kurtosis(Kr) values in the frontal lobe, temporal lobe, and caudate nucleus of children with ADHD were lower than those of healthy children, while the mean diffusivity(MD) and fractional anisotropy of kurtosis (FAK) values were higher than those of healthy children (p < .05). Additionally, the Ka, MK, FA, and Kr values in the frontal lobe, caudate nucleus, and temporal lobe could be used to distinguish children with ADHD (AUC > .05, p < .05). In conclusion, DKI showed abnormal gray matter and white matter development in some brain regions of children with ADHD.

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Section: Discussionmentioning

confidence: 99%

Diffusion kurtosis imaging reveals abnormal gray matter and white matter development in some brain regions of children with attention‐deficit/hyperactivity disorder

Tang,

Liu,

Nie

et al. 2023

J of Neuroscience Research

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“…It informs early intervention strategies, facilitating timely diagnosis and tailored support to address the challenges associated with ADHD. Furthermore, this knowledge guides educational institutions in adapting teaching methods to accommodate students with ADHD, potentially enhancing academic outcomes and reducing dropout rates [6][7][8][9]. On a broader scale, grasping these trends aids policymakers in allocating resources for mental health services, fostering an inclusive and supportive environment for youth with ADHD, and ultimately supporting their overall well-being and productivity as they transition into adulthood [10].…”

Section: Introductionmentioning

confidence: 99%

Attention-Deficit Hyperactivity Disorder Among American Youth: A Comprehensive 20-Year Analysis of National Center for Health Statistics (NCHS) Data

Habdank-Kolaczkowski,

Akahara,

Ishola

et al. 2023

Cureus

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Background: Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental condition that has a significant impact on the lives of children and adolescents. This study conducts a comprehensive 20-year analysis of data from the National Center for Health Statistics (NCHS) to investigate the prevalence of ADHD among American youth, as well as its demographic patterns and socioeconomic determinants. Methods: A retrospective analysis of NCHS data spanning from 1997 to 2018 was carried out. The dataset included information on ADHD diagnoses, demographic characteristics (such as age, gender, and race/ethnicity), socioeconomic indicators (including poverty level and health insurance status), and temporal variables. A range of statistical analyses were performed, encompassing temporal trend analysis, demographic assessments, and socioeconomic examinations. Results: It was consistently observed that boys had a higher prevalence of ADHD (12.93% compared to 5.61%), aligning with established trends. Among adolescents aged 10-17, the prevalence was the highest at 11.09%, while for the 5-9 age group, it stood at 6.57%. In terms of racial and ethnic groups, individuals identifying as two or more races exhibited the highest prevalence at 12.36%, followed by white (9.83%), black or African American (10.09%), Hispanic or Latino (5.36%), and non-Hispanic or Latino (10.64%). Socioeconomic disparities were evident, with a prevalence of 11.41% among those living below the poverty line, compared to 10.6% (100%-199% of the poverty line), 8.6% (200%-399%), and 8.39% (400% or more). Medicaid beneficiaries had the highest prevalence at 12.57%, followed by those with private insurance (9.65%), insured (8.11%), and uninsured (5.83%). Conclusion: These findings underscore the intricate relationship between ADHD prevalence and demographic and socioeconomic factors. It is imperative to address these disparities to ensure equitable assessment and intervention for ADHD, taking into account cultural influences, determinants of health tied to socioeconomic status, and access to healthcare for all children. This analysis by the NCHS provides essential insights into ADHD among American youth, emphasizing the necessity for tailored interventions, equitable healthcare access, and further research to comprehensively address this complex neurodevelopmental disorder.

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Diagnosis and Management of Comorbid ADHD in Patients with Substance Use Disorders

Busch

2024

Psychiatry and Neuroscience Update – Vol. V

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Better characterization of attention and hyperactivity/impulsivity in children with ADHD: The key to understanding the underlying white matter microstructure

Cited by 4 publications

References 78 publications

Diffusion kurtosis imaging reveals abnormal gray matter and white matter development in some brain regions of children with attention‐deficit/hyperactivity disorder

Diffusion kurtosis imaging reveals abnormal gray matter and white matter development in some brain regions of children with attention‐deficit/hyperactivity disorder

Attention-Deficit Hyperactivity Disorder Among American Youth: A Comprehensive 20-Year Analysis of National Center for Health Statistics (NCHS) Data

Diagnosis and Management of Comorbid ADHD in Patients with Substance Use Disorders

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