2007
DOI: 10.3121/cmr.2007.708
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Better Management of Cardiovascular Diseases by Pulse Wave Velocity: Combining Clinical Practice with Clinical Research using Evidence-Based Medicine

Abstract: Arterial stiffness measured by pulse wave velocity (PWV) is an accepted strong, independent predictor of cardiovascular events and mortality. However, lack of a reliable reference range has limited its use in clinical practice. In this evidence-based review, we applied published data to develop a PWV risk stratification model and demonstrated its impact on the management of common clinical scenarios. After reviewing 97 studies where PWV was measured, 5 end-stage renal disease patients, 5 hypertensives, 2 diabe… Show more

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Cited by 56 publications
(38 citation statements)
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“…5 In this context, it has been widely recognized that aortic pulse wave velocity (aPWV) is a sensitive marker of arterial stiffness and, consequently, of cardiovascular outcome. [6][7][8][9] In a previous work, including more than 1000 children and teenagers, we provided reference values for pulse wave velocity (PWV), thereby constituting a suitable tool for longitudinal clinical studies assessing subgroups of children who are at long-term risk of cardiovascular disease. 10 A multitude of various methods and techniques have been used to assess PWV in adults such as applanation tonometry, 11,12 ultrasound, 13,14 methods using mechanotransducers 15 and computerized oscillometry; 16 furthermore, a number of comparative studies with diverging results have been published concerning the comparability of the different methods.…”
Section: Introductionmentioning
confidence: 99%
“…5 In this context, it has been widely recognized that aortic pulse wave velocity (aPWV) is a sensitive marker of arterial stiffness and, consequently, of cardiovascular outcome. [6][7][8][9] In a previous work, including more than 1000 children and teenagers, we provided reference values for pulse wave velocity (PWV), thereby constituting a suitable tool for longitudinal clinical studies assessing subgroups of children who are at long-term risk of cardiovascular disease. 10 A multitude of various methods and techniques have been used to assess PWV in adults such as applanation tonometry, 11,12 ultrasound, 13,14 methods using mechanotransducers 15 and computerized oscillometry; 16 furthermore, a number of comparative studies with diverging results have been published concerning the comparability of the different methods.…”
Section: Introductionmentioning
confidence: 99%
“…A stiff artery could result from either or both of the following conditions: 1) physiologic impairment of the arterial tissue, 2) occlusion inside the artery, i.e., atherosclerosis. Arterial stiffness is an accepted, strong, independent predictor of cardiovascular events and mortality [50]. While direct measurement of PWV is the "gold standard" requiring physician skill and time, a new method based on photoplethysmography is available.…”
Section: The Most Predictive Physiologic Measurement Of Cardiovasculamentioning
confidence: 99%
“…Research is being conducted to correlate arterial stiffness with cognitive disorders, renal disease 16 , diabetes, and arthritis. Advances in the technique of performing PWV will serve to facilitate research in these areas by making measurements easier, less operator dependent, and improving reproducibility within individuals.…”
Section: Discussionmentioning
confidence: 99%