Better Outcome of Patients Undergoing Enteral Tube Feeding After Myeloablative Conditioning for Allogeneic Stem Cell Transplantation

Séguy, D.; Duhamel, Alain; Rejeb, M. Ben; Gomez, E.; Buhl, Nicolas Danel; Bruno, Bénédicte; Cortot, Antoine; Yakoub-Agha, Ibrahim

doi:10.1097/tp.0b013e3182558f60

Cited by 99 publications

(72 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In line with this, enteral nutrition has been associated with reduced aGVHD and lower infection-related mortality, in addition to shorter neutrophil engraftment time. 91 The gut microbiota have been found to play an important role in a wide range of diseases including patients with hematological malignancies undergoing HCT, and increasing attention has been given to the potential of probiotics and prebiotics to prevent and treat intestinal dysbiosis. Probiotics are nutritional supplements containing a defined amount of viable microorganisms that upon administration confer a benefit to the host, 92 whereas prebiotics consist of nondigestible food ingredients (eg, undigested fibers) that support the growth of beneficial bacteria.…”

Section: Nutrition and Gvhdmentioning

confidence: 99%

The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease

Staffas

Silva

Brink

2017

Blood

174

131

View full text Add to dashboard Cite

Hematopoietic cell transplantation (HCT) is a critical treatment of patients with high-risk hematopoietic malignancies, hematological deficiencies, and other immune diseases. In allogeneic HCT (allo-HCT), donor-derived T cells recognize host tissues as foreign, causing graft-versus-host disease (GVHD) which is a main contributor to morbidity and mortality. The intestine is one of the organs most severely affected by GVHD and research has recently highlighted the importance of bacteria, particularly the gut microbiota, in HCT outcome and in GVHD development. Loss of intestinal bacterial diversity is common during the course of HCT and is associated with GVHD development and treatment with broad-spectrum antibiotics. Loss of intestinal diversity and outgrowth of opportunistic pathogens belonging to the phylum Proteobacteria and Enterococcus genus have also been linked to increased treatment-related mortality including GVHD, infections, and organ failure after allo-HCT. Experimental studies in allo-HCT animal models have shown some promising results for prebiotic and probiotic strategies as prophylaxis or treatment of GVHD. Continuous research will be important to define the relation of cause and effect for these associations between microbiota features and HCT outcomes. Importantly, studies focused on geographic and cultural differences in intestinal microbiota are necessary to define applicability of new strategies targeting the intestinal microbiota.

show abstract

Section: Nutrition and Gvhdmentioning

confidence: 99%

The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease

Staffas

Silva

Brink

2017

Blood

174

131

View full text Add to dashboard Cite

show abstract

“…Using the gut might be beneficial to maintain its integrity or improve glucose control, which may reduce the risk of GVHD [41,42,44]. Other groups also reported feasibility and promising results of using EN after HSCT [45][46][47].…”

Section: Nutritional Management During the Early Period After Hsctmentioning

confidence: 91%

“…Use of enteral nutrition (EN) can be an important alternative, as Seguy et al reported the possible benefit using EN after HSCT [41][42][43]. Using the gut might be beneficial to maintain its integrity or improve glucose control, which may reduce the risk of GVHD [41,42,44].…”

Section: Nutritional Management During the Early Period After Hsctmentioning

confidence: 98%

Systematic Nutritional Support in Allogeneic Hematopoietic Stem Cell Transplant Recipients

Fuji

Einsele

Savani

et al. 2015

Biology of Blood and Marrow Transplantation

View full text Add to dashboard Cite

Allogeneic hematopoietic stem cell transplantation (HSCT) has become an established treatment modality for various hematological diseases. However, in allogeneic HSCT, patients often suffer from severe gastrointestinal complications caused by the conditioning regimen and acute/chronic graft-versus-host disease, which requires support by multidisciplinary nutritional support teams (NST). In addition, pretransplantation nutritional status can affect the clinical outcome after allogeneic HSCT. Therefore, it is important to refer the patient to a NST when becoming aware of nutritional problems before allogeneic HSCT. It is also important to follow nutritional status over the long term, as patients often suffer from various nutritional problems, such as malnutrition and metabolic syndrome, even late after allogeneic HSCT. In summary, NST can contribute to the improvement of nutritional status and possibly prognosis at every stage before and after allogeneic HSCT. Here, we aim to give a comprehensive overview of current understanding about nutritional support in allogeneic HSCT and try to provoke a constructive discussion to stimulate further investigation.

show abstract

“…The first 10–15 days are critical especially due to neutropenic mucositis, nausea and poor oral intake 4, 24. It is suggested that maintaining the functions of the digestive tract, even with small volumes of nutrition, could bring beneficial effects in terms of maintenance of the immunological gut barrier and glucose level control 39, 40, 41. However, the use of tube feeding in this population is still being studied and is not standard practice, mainly because of the challenges of establishing a safe enteral access in patients with severe mucositis, gastrointestinal tract damage and thrombocytopenia 24 .…”

Section: Specialized Nutritional Support After Hsct – Enteral Versus mentioning

confidence: 99%

“…When PN is compared to EN, most studies showed several benefits of maintaining the use of the digestive tract during the transplant phases 39, 40, 41. In the same year as Weisdorf et al published their study on PN, Szeluga et al conducted a study to compare EN and PN in pediatric and adult HSCT patients.…”

Section: Specialized Nutritional Support After Hsct – Enteral Versus mentioning

confidence: 99%

Nutritional status and hyperglycemia in the peritransplant period: a review of associations with parenteral nutrition and clinical outcomes

Schumacher

Faulhaber

2017

Revista Brasileira de Hematologia e Hemoterapia

View full text Add to dashboard Cite

Hematopoietic stem cell transplantation is an established treatment option for various hematological diseases. This therapy involves complex procedures and is associated with several systemic complications. Due to the toxic effects of the conditioning regimen used in allogeneic transplantations, patients frequently suffer from severe gastrointestinal complications and are unable to feed themselves properly. This complex clinical scenario often requires specialized nutritional support, and despite the increasing number of studies available, many questions remain regarding the best way to feed these patients. Parenteral nutrition has been traditionally indicated when the effects on gastrointestinal mucosa are significant; however, the true benefits of this type of nutrition in reducing clinical complications have been questioned. Hyperglycemia is a common consequence of parenteral nutrition that seems to be correlated to poor transplantation outcomes and a higher risk of infections. Additionally, nutrition-related pre-transplantation risk factors are being studied, such as impaired nutritional status, poorly controlled diabetes mellitus and obesity. This review aims to discuss some of these recent issues. A real case of allogeneic transplant was used to illustrate the scenario and to highlight the most important topics that motivated this literature review.

show abstract

Better Outcome of Patients Undergoing Enteral Tube Feeding After Myeloablative Conditioning for Allogeneic Stem Cell Transplantation

Cited by 99 publications

References 43 publications

The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease

The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease

Systematic Nutritional Support in Allogeneic Hematopoietic Stem Cell Transplant Recipients

Nutritional status and hyperglycemia in the peritransplant period: a review of associations with parenteral nutrition and clinical outcomes

Contact Info

Product

Resources

About