Better prognostic determination of cT3 rectal cancer through measurement of distance to mesorectal fascia: A multicenter study

Zhang, Xiaoyan; Lu, Qiaoyun; Guo, Xiangjie; Cao, Wuteng; Zhang, Hongmei; Yu, Tao; Li, Xiaoting; Guan, Zhen; Li, Xueping; Sun, Ruoyan; Sun, Yi

doi:10.21147/j.issn.1000-9604.2021.05.07

Cited by 3 publications

(3 citation statements)

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“…The extent of invasion beyond the rectum should be taken into account when substaging stage cT3 rectal cancer, according to regulations from the Union for International Cancer Control (UICC): T3a (<1 mm), T3b (1-5 mm), T3c (5-15 mm), and T3d (>15 mm). 17 However, this stage was subclassified by the Radiological Society of North America into T3a (<5 mm), T3b (5-10 mm), and T3c (>10 mm). 18 Cho et al 19 researched the effect of MRI-mediated T3 substaging on prognosis and discovered that the extent of tumor invasion was an independent prognostic factor for 3-year DFS (hazard ratio, 2.186; 95% CI, 1.336-3.577; p = 0.002) and that the 3-year DFS for T3a, T3b, and T3c was 86%, 69%, and 43%, respectively ( p < 0.03).…”

Section: Discussionmentioning

confidence: 99%

“…The extent to which the tumor has spread beyond the rectum's lamina propria must be determined for stage cT3 rectal cancer in order to develop treatment strategies and determine patients' prognoses. The extent of invasion beyond the rectum should be taken into account when substaging stage cT3 rectal cancer, according to regulations from the Union for International Cancer Control (UICC): T3a (<1 mm), T3b (1–5 mm), T3c (5–15 mm), and T3d (>15 mm) 17 . However, this stage was subclassified by the Radiological Society of North America into T3a (<5 mm), T3b (5–10 mm), and T3c (>10 mm) 18 .…”

Section: Discussionmentioning

confidence: 99%

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The importance of preoperative T3 stage substaging by 3D endorectal ultrasonography for the prognosis of middle and low rectal cancer

Liu,

Zang,

Zhou

et al. 2023

J of Clinical Ultrasound

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ObjectiveThe study aimed to validate the role of 3D‐endorectal ultrasonography in prognosis and recurrence for patients with T3‐stage rectal cancer by evaluating the preoperative extramural depth of tumor invasion.MethodsIn this study, we investigated the medical records of rectal cancer patients who were admitted to Changhai Hospital's Colorectal Surgery Division. The sample group was categorized into three subgroups (T3a, T3b, and T3c) based on the extent of tumor progression (<5 mm, 5–10 mm, and >10 mm) to assess the endorectal ultrasonography diagnostic performance. The 5‐year disease‐free survival and overall survival were assessed using the Kaplan‐Meier method and a log rank test. Cox regression analysis verified the tumor invasion depth's significance as a prognostic predictor, and it was also utilized to evaluate other independent risk variables for recurrence after surgery.ResultsThe study included 72 individuals with low and middle rectal cancer from January 2014 to November 2019. Twenty‐two individuals had stage T3a, 22 had stage T3b, and 28 had stage T3c based on preoperative endorectal ultrasonography. Endorectal ultrasonography had 88.0%, 86.8%, and 76.2% overall accuracy for stratifying subgroups, respectively. According to the Kaplan‐Meier curve, 5‐year OS was 100%, 83.5%, and 92.9% for T3a, T3b, and T3c (p = 0.172), and 5‐year disease‐free survival was 100%, 80.8%, and 72.9% for T3a, T3b, and T3c, respectively (p = 0.014). A distinct risk factor for 5‐year disease‐free survival was the degree of tumor infiltration (p = 0.039).ConclusionPreoperative T3 stage subdivision allows for categorization of prognosis and survival. Endorectal ultrasonography reports should make explicit declarations of T3a, T3b, and T3c scales.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The importance of preoperative T3 stage substaging by 3D endorectal ultrasonography for the prognosis of middle and low rectal cancer

Liu,

Zang,

Zhou

et al. 2023

J of Clinical Ultrasound

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show abstract

“…In total, 187 patients were enrolled in the study with an average PTV of 16.2±11.1 (2.07-72.68) cm 3 . The longest distance outside the muscularis propria was 3.8±3.1 [1][2][3][4][5][6][7][8][9][10][11][12][13][14] mm; positive correlation with PTV (r=0.581, P<0.001). Based on a PTV best cutoff point of 15 cm 3 (5), the patients were divided into the PTV ≤15 cm 3 group and the PTV >15 cm 3 group, which had 3-year DFS rates of 86.6% and 64.6% (P≤0.001), distant metastasis (DM) rates of 8.9% and 23.0% (P=0.001), and LR rates of 4.7% and 16.7% (P=0.004), respectively.…”

Section: Effects Of Different Factors On Prognosismentioning

confidence: 99%