Better Survival With Statin Administration After Revascularization Therapy in Japanese Patients With Coronary Artery Disease  Perspectives From the CREDO-Kyoto Registry

Furukawa, Yutaka; Taniguchi, Ryoji; Ehara, Natsuhiko; Ozasa, Neiko; Haruna, Yoshisumi; Saito, Naritatsu; Doi, Takahiro; Hoshino, Kozo; Shizuta, Satoshi; Morimoto, Takeshi; Imai, Yukiko; Teramukai, Satoshi; Fukushima, Masanori; Kita, Toru; Kimura, Takeshi; Investigators, CREDO-Kyoto

doi:10.1253/circj.cj-08-0293

Cited by 25 publications

(19 citation statements)

References 42 publications

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“…30 Statin therapy begun at the time of hospital discharge has been associated with improved survival in Japanese patients undergoing their first coronary revascularization by percutaneous coronary intervention or CABG. 31 Consistent with this finding, the 2015 American Heart Association Scientific Statement recommended that, unless contraindicated, all CABG patients should receive statin therapy, starting in the preoperative period and restarting soon after surgery. 30 We believe that most, if not all, hospitals in Japan follow this recommendation.…”

Section: Discussionmentioning

confidence: 92%

Is Bilateral Internal Mammary Arterial Grafting Beneficial for Patients Aged 75 Years or Older?

Itoh

Kimura

Adachi

et al. 2016

Circ J

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Background: Although bilateral internal mammary artery (BIMA) grafting is performed with increasing regularity in elderly patients, whether it is truly beneficial, and therefore indicated, in these patients remains uncertain. We retrospectively investigated early and late outcomes of BIMA grafting in patients aged ≥75 years. Methods and Results:We identified 460 patients aged ≥75 years from among 2,618 patients who underwent either single internal mammary artery (SIMA) grafting (n=293) or BIMA grafting (n=107). Early outcomes did not differ between the SIMA and BIMA patients (30-day mortality: 1.7% vs. 0%, P=0.39; sternal wound infection: 1.0% vs. 4.7%; P=0.057). Late outcomes, 10-year survival in particular, were improved in the BIMA group (36.6% vs. 48.1%, P=0.033). In the analysis of the results in propensity score-matched groups (196 patients in the SIMA group, 98 patients in the BIMA group), improved 10-year survival was documented in the BIMA group (34.8% vs. 47.6%, P=0.030). Cox proportional regression analysis showed SIMA usage (non-use of BIMA) to be a predictor for late mortality (hazard ratio: 0.65, 95% confidence interval: 0.43-0.98, P=0.042). We further compared outcomes between the total non-elderly patients (n=2,158) and total elderly patients (n=460). BIMA usage was similar, as was 30-day mortality (1.0% vs. 1.3%, respectively). Conclusions:A survival advantage, with no increase in early mortality, can be expected from BIMA grafting in patients aged ≥75 years. (Circ J 2016; 80: 1756 -1763

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Section: Discussionmentioning

confidence: 92%

Is Bilateral Internal Mammary Arterial Grafting Beneficial for Patients Aged 75 Years or Older?

Itoh

Kimura

Adachi

et al. 2016

Circ J

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“…[5][6][7] Recent clinical studies report that preoperative statin treatment significantly decreases the incidence of AF following CABG with cardiopulmonary bypass. 3,[7][8][9][10] However, there are only a few reports on statins preventing AF following CABG without cardiopulmonary bypass (off-pump CABG (OPCABG)). Song et al report that pretreatment with atorvastatin significantly reduced the occurrence of AF following OPCABG, 11 but as their study was not a double-blind and placebo-controlled trial, definitive conclusions cannot be drawn.…”

mentioning

confidence: 99%

Effect of Preoperative Atorvastatin Therapy on Atrial Fibrillation Following Off-Pump Coronary Artery Bypass Grafting

Mei

Wang

et al. 2009

Circ J

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“…55 Observational studies in Japanese populations of patients with a history of CHD or acute MI have found that those on statins had lower all-cause and CV mortality compared with those not administered statins. [56][57][58] In the CREDO-Kyoto registry, patients with CHD who were discharged on statins had significantly better crude stroke-free survival rates, but statin therapy did not independently predict stroke. 58 …”

Section: Japanese Populationmentioning

confidence: 99%

“…[56][57][58] In the CREDO-Kyoto registry, patients with CHD who were discharged on statins had significantly better crude stroke-free survival rates, but statin therapy did not independently predict stroke. 58 …”

Section: Japanese Populationmentioning

confidence: 99%

A review of statin use in patients with acute coronary syndrome in Western and Japanese populations

Miyauchi

Ray

2013

J Int Med Res

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Early high-dose statin therapy to reduce low-density lipoprotein cholesterol (LDL-C) is associated with improved cardiovascular outcomes in Western patients with stable coronary heart disease or acute coronary syndromes (ACS), but many patients remain undertreated and do not attain LDL-C treatment goals. Early statin therapy has also been shown to improve cardiovascular outcomes in Japanese patients with ACS, and pretreatment with high-dose statin prior to percutaneous coronary intervention has been shown to reduce cardiovascular events in these patients. As is the case in Western populations, many Japanese patients may be undertreated and a residual cardiovascular risk remains. While differences in treatment practice, dosing and genetic factors exist between Japan and Western countries, similarities are also evident when Japanese statin studies are compared with those performed in Western populations. With the increasing prevalence of cardiovascular risk factors in Japan, aggressive statin treatment may be beneficial in achieving optimal cardiovascular outcomes.

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Better Survival With Statin Administration After Revascularization Therapy in Japanese Patients With Coronary Artery Disease Perspectives From the CREDO-Kyoto Registry

Cited by 25 publications

References 42 publications

Is Bilateral Internal Mammary Arterial Grafting Beneficial for Patients Aged 75 Years or Older?

Is Bilateral Internal Mammary Arterial Grafting Beneficial for Patients Aged 75 Years or Older?

Effect of Preoperative Atorvastatin Therapy on Atrial Fibrillation Following Off-Pump Coronary Artery Bypass Grafting

A review of statin use in patients with acute coronary syndrome in Western and Japanese populations

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