Better Together? Coupling Pharmacotherapies and Cognitive Interventions With Non-invasive Brain Stimulation for the Treatment of Addictive Disorders

Spagnolo, Primavera A.; Montemitro, Chiara; Pettorruso, Mauro; Martinotti, Giovanni; Giannantonio, Massimo Di

doi:10.3389/fnins.2019.01385

Cited by 14 publications

(5 citation statements)

References 55 publications

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“…Also, developing realistic preclinical models could help uncover the true rTMS mechanism of action related to neuroplastic change thus optimizing clinical rTMS applications. Combining rTMS with other interventions (either behavioral or pharmacological) is a promising area of research that should be systematically explored as it could improve treatment outcomes beyond any single intervention (c.f., Spagnolo et al, 2020). Finally, it is essential to understand the universality, or non-universality, of "excitatory" and "inhibitory" rTMS sequences.…”

Section: Resultsmentioning

confidence: 99%

“…This is a very promising development and an exciting area for study with the potential of combining the two interventions to be more effective than each applied serially. Pharmacological interventions could also be considered (Spagnolo et al, 2020). Accounting for the state of the patient will likely prove to be an important variable when developing an effective treatment for SUDs.…”

Section: Overview Of the Special Issuementioning

confidence: 99%

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Transcranial Magnetic Stimulation as an Interventional Tool for Addiction

Steele

2020

Front. Neurosci.

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Section: Resultsmentioning

confidence: 99%

Section: Overview Of the Special Issuementioning

confidence: 99%

Transcranial Magnetic Stimulation as an Interventional Tool for Addiction

Steele

2020

Front. Neurosci.

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“…From a mechanistic point of view, we might obtain additive effects of both methods in terms of bottom-up and top down modulations. That is to say, when a specific neural network (bottom-up modulation) that is related to psychological aspects of interest (top down) is modulated, the combination of methods may lead to synergic effects (Spagnolo et al, 2020). As far as we know, only one research was focused on the efficacy of concurrently combining tDCS with a neurobehavioral method.…”

Section: Current Workmentioning

confidence: 99%

Adult ADHD Treatment Based on Combination of Dialectical Behavior Therapy (DBT) and Transcranial Direct Current Stimulation (tDCS) as Measured by Subjective and Objective Scales

Basiri

Hadianfard

2022

J Atten Disord

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Almost 30% of ADHD adults do not respond to standard pharmaceuticals. Transcranial direct current stimulation (tDCS) is a method for modulation of cortical excitability. On the other hand, dialectical behavioral therapy (DBT) is a cognitive-behavioral approach that might be utilized for adults with ADHD. The effects of integration of these interventions are only beginning to be explored. In the present work, we used both subjective and objective measures to investigate the effects of tDCS, DBT, and the integration of the two in treating adult ADHD symptoms. A total of 80 adults with ADHD (63 females, 17 males) participated in the study and were grouped into control, DBT, tDCS, and combined groups. Based on the observed results, the combination of DBT and tDCS was significantly effective in improving the mentioned variables compared to administration of each method in isolation. The results are discussed in terms of neurophysiological and psychological aspects of treatment methods.

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“…The manipulation of brain states through the combination of pharmacotherapy and cognitive training or therapy, along with non-invasive brain treatments, may result in more significant neuroplasticity changes than either intervention alone (Spagnolo et al, 2020;Steele, 2020). Preliminary findings suggest that the application of transcranial magnetic stimulation as a therapeutic intervention may reduce drug craving in individuals using methamphetamine (Liang et al, 2018), nicotine (Li et al, 2013), heroin (Shen et al, 2016), alcohol (Mishra et al, 2010), and cocaine (Hanlon et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

The effectiveness of Non-invasive Brain Stimulation (NIBS) in combination with Cognitive Analytic Therapy (CAT); a complex cocaine abuser case

Khodayarifard,

Kamranvand,

Rostami

2024

Preprint

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Drug addiction, a global problem affecting 275 million people, is a complex disorder characterized by compulsive substance use despite negative consequences. Neuroplasticity changes in the brain’s circuits, particularly those involving dopamine, play a crucial role in addiction. Non-invasive brain stimulation techniques, such as transcranial magnetic stimulation and transcranial direct current stimulation, show promise as adjunctive treatments for substance use disorders, including cocaine use disorder. Combining these brain stimulation therapies with psychological interventions may enhance treatment outcomes and reduce relapse rates. In this study, a 38-year-old Iranian woman, diagnosed with cocaine use disorder, underwent a multi-faceted neuropsychological treatment program. Her husband also received psychological treatment but not biological treatment. After treatment, both the woman and her husband were able to completely stop using cocaine for more than three years. The study used various assessments, including self-report tests and brain mapping, to evaluate the effectiveness of the interventions. The woman showed a significant reduction in symptoms and improvement in mood regulation. This study highlights the effectiveness of a multifaceted approach to treating cocaine addiction, including neurological and psychological interventions. It suggests that non-invasive brain manipulation and Cognitive Analytic Therapy (CAT) may be effective in treating complex cases. However, further research is needed to establish the efficacy of CAT for bipolar affective disorder. The study emphasizes the importance of considering biological, psychological, and social factors in the treatment of substance use disorders.

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Better Together? Coupling Pharmacotherapies and Cognitive Interventions With Non-invasive Brain Stimulation for the Treatment of Addictive Disorders

Cited by 14 publications

References 55 publications

Transcranial Magnetic Stimulation as an Interventional Tool for Addiction

Transcranial Magnetic Stimulation as an Interventional Tool for Addiction

Adult ADHD Treatment Based on Combination of Dialectical Behavior Therapy (DBT) and Transcranial Direct Current Stimulation (tDCS) as Measured by Subjective and Objective Scales

The effectiveness of Non-invasive Brain Stimulation (NIBS) in combination with Cognitive Analytic Therapy (CAT); a complex cocaine abuser case

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