Catastrophe risk governance has become one of the key issues affecting global sustainable development. As great changes have taken place in the global social ecosystem, the degree of interconnection between different regions in today’s society is much greater than ever before. Various types of contact networks, e.g., the production chain and supply chain, have been created, which provide diversified channels for the spread of catastrophe risk across time and space. In the context of interconnection, this paper first analyzes the drastic changes of the current disaster risk system. Severe catastrophe risk has posed a great threat to the highly growing international trade, and has also tested the capabilities of national comprehensive disaster defense. Thus, this paper analyzes the main characteristics of China’s comprehensive disaster defense capability, including physical, social, and humanistic defense capability. Finally, this paper puts forward the key points to resolve catastrophe risk from the perspective of decision-makers, including improving the decision-makers’ ability to study and judge the catastrophe chain and the impact of catastrophe, and the national resource reserve capacity to cope with the catastrophe.