Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits

Smiljanic, Sandra; Messaraa, Cyril; Lafon-Kolb, Virginie; Hrapovic, Nina; Amini, Nahid; Osterlund, Christina; Visdal-Johnsen, Lene

doi:10.3390/ijms232012507

Cited by 6 publications

(1 citation statement)

References 33 publications

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“…Birch juice, a colorless and transparent or can be slightly yellow fresh juice from the birch, contains rich nutrients and biologically active material. It is often regarded as a kind of simple and quick beverage, and it also has medicinal and cosmetic effects [10][11][12][13][14]. To date, birch juice contains 11 kinds of fatty acids, 18 kinds of amino acids, 4 kinds of vitamins and 18 kinds of mineral elements as well as compounds of nicotinic acid, essential oil, betula bud acid, saponin, cell division elements, growth elements, sulfur ammonia elements, and pyridoxine [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Clinical study of a spray containing birch juice for repairing sensitive skin

Shu

Zhao²,

Huo

et al. 2023

Arch Dermatol Res

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Sensitive skin is described as an unpleasant sensory response to a stimulus that should not cause a sensation. Sensitive skin affects an increasing proportion of the population. Sixty-seven participants who tested positive to lactic acid sting test were recruited and randomized into two groups to observe the clinical efficacy and safety of a new birch juice spray for repairing sensitive skin. One group used test spray A, while the other group used spray B as a control. Both groups were sprayed six times daily for 28 days. Noninvasive testing instruments were used to measure stratum corneum hydration, sebum content, transepidermal water loss rates, skin blood perfusion and current perception threshold before and after using spray. Facial images were captured by VISIA-CR, and the image analysis program (Image‐Pro Plus) was used to analyze these to obtain the redness value of the facial skin. Moreover, lactic acid sting test scores and participants’ self-assessments were also performed at baseline, week 2 and week 4. Both sprays A and B significantly decreased the lactic acid sting test score, transepidermal water loss rates, skin blood perfusion, and redness, while increasing the stratum corneum hydration. Compared to spray B, spray A increased sensory nerve thresholds at 5 Hz and decreased the transepidermal water loss rates, skin blood perfusion, and lactic acid sting test score. Sprays containing birch juice improved cutaneous biophysical properties in participants with sensitive skin.

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Section: Introductionmentioning

confidence: 99%

Clinical study of a spray containing birch juice for repairing sensitive skin

Shu

Zhao²,

Huo

et al. 2023

Arch Dermatol Res

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Exploring the Role of Herbal Compounds in Skin Aging: A Systematic Review of Topical Approaches

Goh,

Tow

et al. 2024

Phytotherapy Research

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Recently, dermatology has increasingly focused on understanding skin aging and exploring novel therapeutic approaches. Despite progress in cosmetic and pharmaceutical research, a significant gap remains in comprehensively understanding the effects and mechanisms of herbal extracts on skin aging. While many studies have examined the bioactivities of herbal compounds in preclinical models, comprehensive human trials have been scarce over the past decade. This review aims to address this gap by synthesizing human trials from the past decade, focusing on the therapeutic effects of herbal extracts on skin aging. The objective is to unravel the mechanisms contributing to skin aging and assess the therapeutic potential of herbal compounds. Following the PRISMA 2020 guideline, a systematic review was performed across OvidMEDLINE, Cochrane Central Register of Controlled Trials, and Embase via Ovid. A meticulous search strategy identified relevant clinical trials. The review highlights the essential role of herbal compounds in skin aging, particularly their antioxidant activity in suppressing the aging process. Analysis of 51 clinical trials offers valuable insights into their diverse effects on skin aging parameters. Herbal compounds are promising alternatives to synthetic products for treating skin aging. Their demonstrated efficacy in mitigating wrinkles, enhancing elasticity, maintaining hydration, and controlling pigmentation underscores their potential in developing antiaging therapeutics. However, further studies are needed to identify specific compounds responsible for these effects and understand their mechanisms. Future directions include conducting large‐scale trials, exploring synergies with other ingredients, and optimizing delivery systems for sustainable, effective antiaging therapies.

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A review of catechins and their use in atopic dermatitis

Beagles,

Lerner

2024

Itch

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Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by persistent itching of the skin with its prevalence increasing in the United States. AD has a complex pathogenesis that remains to be fully resolved, though it is shown to involve immune dysregulation and skin barrier dysfunction, with multiple environmental and genetic factors implicated. The interplay between the immune system and environmental exposures can incite immune responses with the release of cytokines, IgE, eosinophils, and mast cells, which trigger symptoms of AD in susceptible patients. There are many therapies used in AD; however, the first-line treatment for flares continues to be corticosteroids. The broad range of therapies available for AD is associated with adverse effects, poor adherence, and financial burden, accentuating the need to assess alternative therapies. A promising alternative therapy is the catechin family, a group of flavonoids with a unique structure that has anti-inflammatory, antimicrobial, antioxidant, and skin barrier modulating properties. In this review, we describe the structure and related properties of catechins, their function, and how they can be utilized in the treatment of AD. Furthermore, we describe limitations associated with the use of catechins and the necessity of further research in this area. The function of catechins has been widely shown to modulate the inflammatory pathway and skin barrier dysfunction that have been implicated in AD and reduce symptoms. While catechins can mitigate symptoms and reduce associated inflammatory markers, further research is required to develop a therapy that retains the beneficial functions of catechins without increasing cytotoxicity.

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Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits

Cited by 6 publications

References 33 publications

Clinical study of a spray containing birch juice for repairing sensitive skin

Clinical study of a spray containing birch juice for repairing sensitive skin

Exploring the Role of Herbal Compounds in Skin Aging: A Systematic Review of Topical Approaches

A review of catechins and their use in atopic dermatitis

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