Betulinic acid negates oxidative lung injury in surgical sepsis model

Lingaraju, Madhu Cholenahalli; Pathak, N.N.; Begum, Jubeda; Balaganur, Venkanna; Bhat, Rafia Ahmad; Ram, Mahendra; Kumar, Dhirendra; Kumar, Dinesh; Tandan, Surendra K.

doi:10.1016/j.jss.2014.09.008

Cited by 20 publications

(15 citation statements)

References 54 publications

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“…The generation of ROS is an unavoidable consequence of living in an oxygen rich environment and organisms have evolved with elaborate [32][33][34], influenza A [35], hyperoxia [36], toxic gas [37], ischemia-reperfusion (I/R) [38], sepsis [39,40], acid aspiration [41], burn and smoke inhalation [42] as well as high tidal mechanical ventilation [43][44][45]. Figure 2 illustrates the biological origins of ROS in a cell.…”

Section: Ros In Vascular Tissuementioning

confidence: 99%

ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)

Kellner

Noonepalle

Lü

et al. 2017

Advances in Experimental Medicine and Biology

298

256

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The generation of reactive oxygen species (ROS) plays an important role for the maintenance of cellular processes and functions in the body. However, the excessive generation of oxygen radicals under pathological conditions such as acute lung injury (ALI) and its most severe form acute respiratory distress syndrome (ARDS) leads to increased endothelial permeability. Within this hallmark of ALI and ARDS, vascular microvessels lose their junctional integrity and show increased myosin contractions that promote the migration of polymorphonuclear leukocytes (PMNs) and the transition of solutes and fluids in the alveolar lumen. These processes all have a redox component, and this chapter focuses on the role played by ROS during the development of ALI/ARDS. We discuss the origins of ROS within the cell, cellular defense mechanisms against oxidative damage, the role of ROS in the development of endothelial permeability, and potential therapies targeted at oxidative stress.

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Section: Ros In Vascular Tissuementioning

confidence: 99%

ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)

Kellner

Noonepalle

Lü

et al. 2017

Advances in Experimental Medicine and Biology

298

256

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“…Betulinic acid (3β, hydroxy-lup-20 (29)-en-28-oic acid; BetA) is a naturally occurring pentacyclic triterpenoid found in many kinds of fruits, vegetables and most abundant in the Sambucus williamsii Hance tree [ 8 , 9 ]. In China, stem and ramulus of the tree has been used traditionally as an herbal remedy for osteoporosis, joint diseases and bone fracture [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Betulinic acid synergically enhances BMP2-induced bone formation via stimulating Smad 1/5/8 and p38 pathways

et al. 2016

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BackgroundHealing of bone defects is a dynamic and orchestrated process that relies on multiple growth factors and cell types. Bone morphogenetic protein 2 (BMP2) is a key growth factor for bone healing, which stimulates mesenchymal stem cells to differentiate into osteoblasts. Betulinic acid (BetA) is a natural pentacyclic triterpenoid from plants. This study aimed to examine combinatory effects of BetA and BMP2 on ectopic bone generation in mice.ResultsIn MC3T3-E1 preosteoblast culture, 10–15 μM of BetA increased the alkaline phosphatase (ALP) activity and expression levels of osteogenic marker genes without the decreased cell viability. In addition, BetA synergistically enhanced BMP2-induced gene expressions and mineralization with the enhancement of phosphorylation of Smad1/5/8 and p38. In an in vivo ectopic bone formation model, combination of BetA (50 μg) and BMP2 (3 μg) resulted in increases in the amount of new bone generation, compared with treatment with BMP2 alone. Histological studies showed that bone generation with cortical and trabecular structures was resulted from the combination of BetA and BMP2.ConclusionBetA can enhance in vivo osteogenic potentials of BMP2, possibly via stimulating Smad 1/5/8 and p38 pathways, and combination of both agents can be considered as a therapeutic strategy for bone diseases.Electronic supplementary materialThe online version of this article (doi:10.1186/s12929-016-0260-5) contains supplementary material, which is available to authorized users.

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“…Therefore, it can be a good candidate for clinical trial studies of lung injuries induced by SARS-Cov-2 (Bahrami et al, 2020). On the other hand, triterpenoids such as rubriflordilactones A, betulinic acid, and taraxasterol also have shown ameliorating effects on lung injuries induced by LPS and sepsis (San et al, 2014;Lingaraju et al, 2015; (Table 1). Wang and coworkers showed that the rubriflordilactone, isolated from Schisandra sphenanthera Rehder & E.H.Wilson (syn.…”

Section: Terpenoids and Saponinsmentioning

confidence: 99%

Phytochemicals: Potential Therapeutic Interventions Against Coronavirus-Associated Lung Injury

et al. 2020

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Since the outbreak of coronavirus disease 2019 (COVID-19) in December 2019, millions of people have been infected and died worldwide. However, no drug has been approved for the treatment of this disease and its complications, which urges the need for finding novel therapeutic agents to combat. Among the complications due to COVID-19, lung injury has attained special attention. Besides, phytochemicals have shown prominent anti-inflammatory effects and thus possess significant effects in reducing lung injury caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Also, the prevailing evidence reveales the antiviral effects of those phytochemicals, including anti-SARS-CoV activity, which could pave the road in providing suitable lead compounds in the treatment of COVID-19. In the present study, candidate phytochemicals and related mechanisms of action have been shown in the treatment/protection of lung injuries induced by various methods. In terms of pharmacological mechanism, phytochemicals have shown potential inhibitory effects on inflammatory and oxidative pathways/mediators, involved in the pathogenesis of lung injury during COVID-19 infection. Also, a brief overview of phytochemicals with anti-SARS-CoV-2 compounds has been presented.

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Betulinic acid negates oxidative lung injury in surgical sepsis model

Cited by 20 publications

References 54 publications

ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)

ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)

Betulinic acid synergically enhances BMP2-induced bone formation via stimulating Smad 1/5/8 and p38 pathways

Phytochemicals: Potential Therapeutic Interventions Against Coronavirus-Associated Lung Injury

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