Betulinic acid protects against<i>N</i>-nitrosodimethylamine-induced redox imbalance in testes of rats

Adeleke, G. E.; Adaramoye, Oluwatosin A.

doi:10.1080/13510002.2017.1322750

Cited by 18 publications

(9 citation statements)

References 43 publications

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“…The authors associated the latter observation with the finding that the testosterone levels did not increase. Adeleke and Adaramoye () studied the protective role of betulinic acid on nitrosodimethylamine‐induced redox imbalance in rat testis. They reported that nitrosodimethylamine, a nitrosamine compound, was known for its carcinogenic activity in the liver and kidney of animals; however, the information about the effects on the testis tissue was limited.…”

Section: Discussionmentioning

confidence: 99%

“…They reported that nitrosodimethylamine, a nitrosamine compound, was known for its carcinogenic activity in the liver and kidney of animals; however, the information about the effects on the testis tissue was limited. Adeleke and Adaramoye () demonstrated that the administration of nitrosodimethylamine significantly reduced the sperm density, motility and live‐dead ratio by 57%, 36% and 37%, respectively, and increased the total abnormal sperm rate by 56% while testicular TBARS and total cholesterol levels were increased. The authors determined that betulinic acid displayed protective effects against nitrosodimethylamine‐induced redox imbalance via the activation of the antioxidative pathway.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of ameliorating effect of lycopene against testicular toxicity due to diethylnitrosamine using biochemical, spermatological and histopathological data

Kaya

Yılmaz

et al. 2019

Andrologia

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The aim of this study was to evaluate the possible therapeutic or protective effects of lycopene on diethylnitrosamine (DEN)-induced testicular lipid peroxidation and on the associated changes in spermatological parameters and histopathological architecture of rat testis. DEN is a carcinogenic substance that can be derived from chemicals used in agriculture, such as insecticides and nitrate. The rats were assigned to control, lycopene, DEN(1), DEN(2), lycopene + DEN(1), lycopene + DEN(2), DEN(1) + lycopene and DEN(2) + lycopene groups. During the study, lycopene was administered by oral gavage at a dose of 10 mg kg −1 bw −1 every other day for 10 days and DEN was administered at a dose of 200 mg kg −1 bw −1 as a single dose intraperitoneally. DEN was applied for 30 days in group DEN(1) and for 90 days in group DEN(2). Malondialdehyde (MDA) and reduced glutathione (GSH) levels, antioxidant enzymes activities, spermatological parameters, the weight of the reproductive organs (v. seminalis, prostate, testis and epididymis) and the histopathological structure were determined. MDA levels significantly increased, while GSH and antioxidant enzymes' activities decreased in DEN groups (p < 0.001). There was an increase in the rate of abnormal spermatozoa and a decrease in sperm density and motility, and reproductive organ weight (the weight of the right and left testis) in both DEN groups.Lycopene has normalised biochemical and spermatological parameters and reproductive organ weight. The histopathological examination of testicular tissue showed that the most significant histopathological change in DEN groups was the seminiferous tubule dilatation. These results suggest that besides the protective effects, the therapeutic effect of lycopene is possibly due to its antioxidant effects on DEN-induced testicular toxicity. K E Y W O R D Santioxidant, diethylnitrosamine, lycopene, oxidative stress

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of ameliorating effect of lycopene against testicular toxicity due to diethylnitrosamine using biochemical, spermatological and histopathological data

Kaya

Yılmaz

et al. 2019

Andrologia

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“…These processes results in extreme oxidative stress and production of reactive oxygen species (ROS) that further contributes to hepatocyte damage and necrosis. Furthermore, NDMA decreases catalase and glutathione peroxidase, the major antioxidant enzymes present in the liver 79–81 . We have observed that NDMA treatment dramatically decreases serum and liver concentrations of ascorbic acid, another major antioxidant 10 .…”

Section: Events Involved In the Pathogenesis Of Ndma Induced Hepatic mentioning

confidence: 97%

Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis

2019

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Hepatic fibrosis is marked by excessive synthesis and deposition of connective tissue proteins, especially interstitial collagens in the extracellular matrix of the liver. It is a result of an abnormal wound healing in response to chronic liver injury from various causes such as ethanol, viruses, toxins, drugs, or cholestasis. The chronic stimuli involved in the initiation of fibrosis leads to oxidative stress and generation of reactive oxygen species that serve as mediators of molecular events involved in the pathogenesis of hepatic fibrosis. These processes lead to cellular injury and initiate inflammatory responses releasing a variety of cytokines and growth factors that trigger activation and transformation of resting hepatic stellate cells into myofibroblast like cells, which in turn start excessive synthesis of connective tissue proteins, especially collagens. Uncontrolled and extensive fibrosis results in distortion of lobular architecture of the liver leading to nodular formation and cirrhosis. The perpetual injury and regeneration process could also results in genomic aberrations and mutations that lead to the development of hepatocellular carcinoma. This review covers most aspects of the molecular mechanisms involved in the pathogenesis of hepatic fibrosis with special emphasize on N -Nitrosodimethylamine (NDMA; Dimethylnitorsmaine, DMN) as the inducing agent.

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“…We have earlier reported that BA ameliorated NDMA-induced adverse effects on the activities of UDPGT, AnH, and AmD in the testicular organs of rats. [54] Histopathology revealed severe periportal cell infiltration by mononuclear cells, periportal fibroplasia (fibrosis), and few foci of necrosis in hepatic tissues, while cortical degeneration, foci tubular necrosis, and tubular deposition of proteinaceous materials in renal tissues of NDMAadministered rats were observed. The infiltration of mononuclear cells into the hepatocytes and deposition of proteinaceous materials in the renal tubular lumen may be due to changes in structural integrity and lipid-protein interaction in biological membranes of these tissues caused by NDMA.…”

Section: Discussionmentioning

confidence: 94%

Betulinic acid abates N‐nitrosodimethylamine‐induced changes in lipid metabolism, oxidative stress, and inflammation in the liver and kidney of Wistar rats

Adeleke

Adaramoye

2021

J Biochem & Molecular Tox

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N-nitrosamines have been linked with cancer in humans due to their presence in drinking water and diets. This study evaluated the role of betulinic acid (BA) in abating oxidative stress, inflammation, and hyperlipidemia in rats treated with N-nitrosodimethylamine (NDMA). Twenty-four male rats were assigned into four equal groups. Group I served as the control, Group II received BA (25 mg/kg), Group III received NDMA (5 mg/kg) and, Group IV received BA (25 mg/kg) and NDMA (5 mg/kg). Results showed that the administration of NDMA significantly (p < 0.05) elevated malondialdehyde in the liver and kidney relative to controls. Activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase, and the level of glutathione were significantly (p < 0.05) decreased by NDMA, while treatment with BA elevated the activities of these enzymes in the liver and kidney. The BA lowered serum interleukin-6 and tumor necrosis factor-alpha levels against the NDMA effect. Furthermore, NDMA increased hepatic and renal triglyceride while phospholipids levels were decreased. NDMA significantly modulated the activities of drug-metabolizing enzymes (aniline hydroxylase, aminopyrine-N-demethylase, and uridyldiphosphoglucuronyltransferase), while BA was able to restore these enzymes to values close to controls. Histology revealed the presence of infiltration and fibroplasia in the liver, while cortical degeneration was noticed in the kidney in NDMA-administered rats. These lesions were reduced in the NDMA rats treated with BA. The findings suggest that BA improves NDMA-induced damage in the liver and kidney of rats through reactions that can be linked with antioxidant, anti-inflammatory, and lipid-lowering pathways.

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Betulinic acid protects againstN-nitrosodimethylamine-induced redox imbalance in testes of rats

Cited by 18 publications

References 43 publications

Evaluation of ameliorating effect of lycopene against testicular toxicity due to diethylnitrosamine using biochemical, spermatological and histopathological data

Evaluation of ameliorating effect of lycopene against testicular toxicity due to diethylnitrosamine using biochemical, spermatological and histopathological data

Molecular mechanisms in the pathogenesis of N-nitrosodimethylamine induced hepatic fibrosis

Betulinic acid abates N‐nitrosodimethylamine‐induced changes in lipid metabolism, oxidative stress, and inflammation in the liver and kidney of Wistar rats

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