Between-visit variability of small airway obstruction markers in patients with asthma

Gonem, Sherif; Corkill, Steven; Singapuri, Amisha; Gustafsson, Per; Costanza, Rino; Brightling, Christopher E.; Siddiqui, Salman

doi:10.1183/09031936.00001814

Cited by 19 publications

(25 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This permits encompassing the stability of the measurement instrument and subject performance, and also the variation related to the disease . Compared to spirometry, the within‐ and between‐day variability of respiratory resistance in asthmatic patients appears higher than the variability of forced expiratory volume in one second (FEV 1 ) and forced vital capacity (FVC), but similar to spirometric indices reflecting lower airway function: the forced expiratory flow at 50%, 75%, and 25‐75% of FVC (FEF 50 , FEF 75 , and FEF 25‐75 , respectively) . Despite the association between small airway dysfunction and clinical expression of asthma, no clinical trials evaluating the effect of asthma‐control medication targeting small airways have been published in children, and measurable endpoints for this purpose are lacking.…”

Section: Discussionmentioning

confidence: 99%

Small airway oscillometry indices: Repeatability and bronchodilator responsiveness in young children

Knihtilä

Kotaniemi‐Syrjänen

Pelkonen

et al. 2017

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Small airway oscillometry indices: Repeatability and bronchodilator responsiveness in young children

Knihtilä

Kotaniemi‐Syrjänen

Pelkonen

et al. 2017

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

“…Intra-visit reproducibility measured by ICC was good (.0.7) for the majority of washout parameters in both groups, except for phase III slope indices of MBW in healthy adults and Scond (6VT) in COPD patients (ICC 0.42-0.66). A recent study similarly found a poor intra-visit reproducibility of Scond (ICC 0.23) in 18 patients with moderate-to-severe asthma [33].…”

Section: Reproducibility Of Washout Indicesmentioning

confidence: 94%

Double tracer gas single-breath washout: reproducibility in healthy subjects and COPD

et al. 2014

View full text Add to dashboard Cite

The applicability and interpretation of inert tracer gas washout tests is hampered by the lack of feasible protocols and reproducibility data. We assessed feasibility, variability and reproducibility of a new easy to perform double tracer gas (DTG) single-breath washout (SBW) test and compared this with conventional nitrogen washouts.In 40 healthy nonsmokers and 20 patients with stable chronic obstructive pulmonary disease (COPD), we performed three N 2 vital capacity SBWs, three N 2 multiple-breath washouts and three tidal DTG-SBW tests. Follow-up was after 1 week, 1 month and 6 months. Main outcomes were the lung clearance index (LCI) (N 2 multiple-breath washout), slope of phase III (dN 2 ) (N 2 vital capacity SBW) and slope of phase III (SIIIDTG) (DTG-SBW).In healthy subjects, mean¡SD LCI at baseline was 6.94¡0.61, dN 2 0.99¡0.42% N 2 per litre and SIIIDTG -0.206¡0.108 g?mol -1 ?L -1 . In COPD, LCI and dN 2 were significantly higher (LCI 12.23¡2.67, dN 2 7.43¡5.38% N 2 per litre; p,0.001) and SIIIDTG significantly steeper (-0.653¡0.428 g?mol -1 ?L -1 , p,0.001). Reproducibility was high for main outcome parameters: the intraclass correlation coefficient over 6 months was 0.77 (0.86 in COPD) for LCI, 0.82 (0.89) for dN 2 and 0.83 (0.93) for SIIIDTG.The tidal DTG-SBW is a reproducible test in healthy and COPD subjects that seems attractive for use in routine clinical settings. @ERSpublications DTG-SBW may play a role in detection and monitoring of small airway diseases or as an outcome in drug trials

show abstract

“…Similarly, children from a Boston cohort with reduced FEF 25-75 have substantially higher risk of exacerbations and systemic steroid use compared with those who have normal lung function [18]. The extent to which small airways define asthma characteristics however is disputed as the relationships are not consistently reproducible [55]. …”

Section: Small Airways In Severe Asthmamentioning

confidence: 99%

Small airways disease and severe asthma

Carr

Altisheh

2017

World Allergy Organization Journal

View full text Add to dashboard Cite

The small airways of the lungs are commonly affected in pediatric and adult asthma. Small airways disease has been related to asthma control, severity, and risk of exacerbation. Diagnosis of small airways disease can be best made through evaluation of surgical lung specimens. Noninvasive techniques including spirometry, plethysmography, nitrogen washout, impulse oscillometry, and cross-sectional imaging have been utilized to assess and infer the extent of small airways disease in asthma and can be used longitudinally to assess response to treatment. Patients with small airways disease seem to benefit from inhaled asthma medications that have improved capacity to reach the distal lung compartment. This is especially important for patients with severe asthma, who rely upon high doses of inhaled corticosteroid and bronchodilators for asthma control. This review will describe the techniques which may be utilized to assess small airways disease, discuss the prevalence and characteristics of small airways disease in severe asthma, and highlight how small airway disease may complicate severe asthma treatment.

show abstract

Between-visit variability of small airway obstruction markers in patients with asthma

Cited by 19 publications

References 12 publications

Small airway oscillometry indices: Repeatability and bronchodilator responsiveness in young children

Small airway oscillometry indices: Repeatability and bronchodilator responsiveness in young children

Double tracer gas single-breath washout: reproducibility in healthy subjects and COPD

Small airways disease and severe asthma

Contact Info

Product

Resources

About