Bevacizumab for Post Vitrectomy Cystoid Macular Edema in a Silicone Oil–filled Eye

Lambat, Sarang; Bajoria, Sheetal; Nangia, Vinay; Nangia, Prabhat; Mishra, Swati D; Shah, Neha

doi:10.1097/icb.0000000000001057

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…A case report by Lambat et al 26 described intravitreal bevacizumab to treat CME under SO, resulting in significant improvement of VA and complete resolution of CME within a week of the injection. Another case report by An and Kim 27 described the use of intravitreal dexamethasone implants, which were not effective before SOR but improved VA and CFT after SOR.…”

Section: Discussionmentioning

confidence: 99%

Clinical Outcome of Cystoid Macular Edema in Silicone Oil–Filled Eyes

Shaheen,

Lai,

Magraner

et al. 2023

Journal of VitreoRetinal Diseases

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Purpose: To investigate the clinical outcome of cystoid macular edema (CME) in eyes undergoing silicone oil (SO) tamponade with subsequent SO removal (SOR). Methods: A retrospective case series of adult patients with CME treated with SO tamponade and SOR was conducted between January 2015 and January 2021. Exclusion criteria included eyes with a prior SO tamponade, those that did not undergo SOR, or those with infectious/inflammatory diagnoses. The primary outcomes were the incidence and resolution rates of CME in eyes with SO tamponade that have undergone SOR. The secondary outcomes included changes in best-corrected visual acuity (BCVA) and central field thickness (CFT). Results: Nineteen eyes of 19 patients (58% men) aged 52 years (IQR, 45-66 years) met study inclusion criteria. The median (IQR) follow-up duration post SOR was 22 (8-35) months. Mean CFT decline for the CME-resolved cases was 13.1 µm/mo ( P = .257). CME resolved in only 10 (53%) eyes, 7 (67%) of which occurred after SOR. Median (IQR) BCVA was 20/400 (20/200 to 20/1262) at CME diagnosis and 20/796 (20/252 to hand motion) after SOR, with 0.184 worsening in logMAR BCVA ( P = .340). Medical treatment was not associated with CME resolution compared with observation (50% vs 89%, respectively; P = .069). Eyes with proliferative vitreoretinopathy (PVR) had a higher rate of persistent CME compared with eyes with other diagnoses (78% vs 10%, respectively; P = .005). Conclusions: Nearly half had nonresolution of CME after SO was removed. Visual acuity at last follow-up was unaffected by CME resolution. Preoperative PVR may be a risk factor for unresolved CME.

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Section: Discussionmentioning

confidence: 99%

Clinical Outcome of Cystoid Macular Edema in Silicone Oil–Filled Eyes

Shaheen,

Lai,

Magraner

et al. 2023

Journal of VitreoRetinal Diseases

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“…Lambat et al reported a case of cystoid macular edema resolved and visual acuity improved in a silicone oil-lled eye treated with an intravitreal injection of bevacizumab [14]. However, there is only one case.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of silicone oil removal combined with intravitreal injection of triamcinolone acetonide in the treatment of macular edema in eyes filled with silicone oil

Huang

et al. 2022

Preprint

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Purpose To investigate the efficacy of silicone oil removal combined with intravitreal injection of triamcinolone acetonide in treating macular edema in silicone oil eyes. Methods Retrospective analysis was performed on the patients with macular edema in eyes filled with silicone oil. The retinal detachment of each patient has been resolved for more than three months. Silicone oil was removed from each patient through pars plana trocar, and 2 mg triamcinolone acetonide suspension was injected into the vitreous cavity. The patients were followed up for at least three months. The best-corrected visual acuity (BCVA) and central foveal thickness (CFT) in each patient were compared with paired t-test. Results Twenty eyes of 20 patients were enrolled in this study and the mean follow-up time was 12.1 months. The mean BCVA improved from 1.08 ± 0.44 LogMAR before the operation to 0.61 ± 0.31 LogMAR at the final visit (P < 0.001). The mean CFT reduced from 478.95 ± 121.97 µm before the operation to 270.20 ± 135.35 µm at the final visit (P < 0.001). Four patients (20%) developed temporal high intraocular pressure (IOP), all of which could be treated with topical IOP-lowering drugs. Conclusion Silicon oil removal combined with intravitreal triamcinolone injection can effectively improve visual acuity and alleviate macular edema without severe complications in silicone oil eyes with macular edema.

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Bevacizumab for Post Vitrectomy Cystoid Macular Edema in a Silicone Oil–filled Eye

Cited by 2 publications

References 11 publications

Clinical Outcome of Cystoid Macular Edema in Silicone Oil–Filled Eyes

Clinical Outcome of Cystoid Macular Edema in Silicone Oil–Filled Eyes

Efficacy of silicone oil removal combined with intravitreal injection of triamcinolone acetonide in the treatment of macular edema in eyes filled with silicone oil

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