Objectives: Determine the frequency of and the predictive factors for abnormal ocular fundus findings among emergency department (ED) headache patients.Methods: Cross-sectional study of prospectively enrolled adult patients presenting to our ED with a chief complaint of headache. Ocular fundus photographs were obtained using a nonmydriatic fundus camera that does not require pupillary dilation. Demographic and neuroimaging information was collected. Photographs were reviewed independently by 2 neuroophthalmologists for findings relevant to acute care. The results were analyzed using univariate statistics and logistic regression modeling.
Results:We included 497 patients (median age: 40 years, 73% women), among whom 42 (8.5%, 95% confidence interval: 6%-11%) had ocular fundus abnormalities. Of these 42 patients, 12 had disc edema, 9 had optic nerve pallor, 6 had grade III/IV hypertensive retinopathy, and 15 had isolated retinal hemorrhages. Body mass index $35 kg/m 2 (odds ratio [OR]: 2.3, p 5 0.02), younger age (OR: 0.7 per 10-year increase, p 5 0.02), and higher mean arterial blood pressure (OR: 1.3 per 10-mm Hg increase, p 5 0.003) were predictive of abnormal retinal photography. Patients with an abnormal fundus had a higher percentage of hospital admission (21% vs 10%, p 5 0.04). Among the 34 patients with abnormal ocular fundi who had brain imaging, 14 (41%) had normal imaging.Conclusions: Ocular fundus abnormalities were found in 8.5% of patients with headache presenting to our ED. Predictors of abnormal funduscopic findings included higher body mass index, younger age, and higher blood pressure. Our study confirms the importance of funduscopic examination in patients with headache, particularly in the ED, and reaffirms the utility of nonmydriatic fundus photography in this setting. In the emergency department (ED), headache is the fourth most common chief complaint among all patients and the single most common neurologic chief complaint.1 More than 3 million ED visits for headache occurred in the United States during 2008, 2 and it is estimated that 3% to 5% of the general population has visited an ED for headache.3 The vast majority of these headaches are primary, requiring only symptomatic relief. 2,4,5 However, approximately 2% of all patients with headache and more than 18% of patients with sudden, severe headaches have a serious underlying cause. 4,[6][7][8][9] The frequency of secondary headaches also increases with age, occurring in almost 15% of headache sufferers older than 75 years. 4 The ED physician has the difficult task of discriminating between nonemergent headaches and those requiring acute care. Examination of the ocular fundus is one aspect of the physical examination that helps screen for potential "red flags," such as papilledema, that suggest a more ominous cause of headache.10,11 Unfortunately, funduscopy, performed infrequently in acute care settings such as the ED, is also not accurately interpreted by nonophthalmology personnel. 10 Our goal was to