2008
DOI: 10.1111/j.1365-2249.2007.03583.x
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BeWo trophoblast cell susceptibility toToxoplasma gondiiis increased by interferon-γ, interleukin-10 and transforming growth factor-β1

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Cited by 53 publications
(81 citation statements)
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“…gondii strains may also differ in their ability to survive within the placenta. Replication rates of type I (RH) T. gondii in BeWo choriocarcinoma cells are controversial, with one report asserting slower parasite replication (56) and others reporting normal growth relative to other cell types (5,52). It is unclear, however, how well this cancerous cell line represents primary trophoblasts, as we have shown that BeWo cells do not restrict growth of L. monocytogenes, while primary isolated cytotrophoblasts and explant EVT do (68).…”
Section: Discussionmentioning
confidence: 84%
See 1 more Smart Citation
“…gondii strains may also differ in their ability to survive within the placenta. Replication rates of type I (RH) T. gondii in BeWo choriocarcinoma cells are controversial, with one report asserting slower parasite replication (56) and others reporting normal growth relative to other cell types (5,52). It is unclear, however, how well this cancerous cell line represents primary trophoblasts, as we have shown that BeWo cells do not restrict growth of L. monocytogenes, while primary isolated cytotrophoblasts and explant EVT do (68).…”
Section: Discussionmentioning
confidence: 84%
“…gondii replication. Studies differ on the question of whether T. gondii replication is inhibited in trophoblast cells using the BeWo choriocarcinoma cell line (5,52,56). We have previously shown that L. monocytogenes growth is impaired in EVT (though not BeWo cells) due to altered vacuole maturation (68).…”
Section: Resultsmentioning
confidence: 99%
“…The function of INHBA expression may be particularly relevant to Toxoplasma infections because INHBA mRNA is up-regulated in Toxoplasma-infected cells (8,43). Interestingly, TGF␤ is also up-regulated in Toxoplasma infections (84 -87) and in some cases can increase host cell susceptibility to infection (88). Thus, it is quite likely that signaling by more than one ALK4,5,7 ligand can signal through one or more receptors to activate HIF-1 in Toxoplasma-infected cells.…”
Section: Discussionmentioning
confidence: 99%
“…42,43 Direct invasion of placental cells by T. gondii is regulated by immune response molecules. Barbosa et al 44 showed that BeWo line trophoblasts are susceptible to invasion and replication, especially if they are Table 1 Human immune response genes: hypothetical effect of some polymorphisms on congenital toxoplasmosis Table 1). 32,35,[45][46][47] It is important to emphasize that BeWo cells are not models for the syncytiotrophoblast, the main mother/conceptus interface.…”
Section: Immune Response In Acquired Toxoplasmosismentioning
confidence: 99%