Amorphus globosus is a rare malformation that is defined as an acardiac asymmetrical rough spherical mass of tissue covered in skin. To authors’ knowledge, amorphus globosus has not been previously reported in canids. Herein, we describe amorphus globosus in an American Bulldog pup with accompanying radiograph, gross images, and histopathology. Additionally, a systematic review (preferred reporting items for systematic reviews and meta-analyses protocol) was performed for veterinary species; amorphus globosus has been reported in 22 bovids, 3 caprids, 1 ovid, and 1 equid.